A5100715667- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Plant-Microbe Interactions and Immunity
- Cancer, Hypoxia, and Metabolism
- Esophageal and GI Pathology
- Pediatric Hepatobiliary Diseases and Treatments
- Microbial metabolism and enzyme function
- Nutrition and Health in Aging
- Gastrointestinal disorders and treatments
- Renal cell carcinoma treatment
- Cancer Research and Treatments
- Cloud Data Security Solutions
- Cancer Cells and Metastasis
- Blockchain Technology Applications and Security
- Cancer Genomics and Diagnostics
- Access Control and Trust
- Pesticide Residue Analysis and Safety
- Peptidase Inhibition and Analysis
- Adrenal and Paraganglionic Tumors
- Epigenetics and DNA Methylation
Seoul National University
2016-2025
The Ohio State University Wexner Medical Center
2024-2025
Pusan National University
2010-2025
Yonsei University
2015-2024
Seoul National University Hospital
2024
Gangnam Severance Hospital
2015-2024
Kyungpook National University
2015-2024
University of Ulsan
2024
Asan Medical Center
2024
Ulsan College
2024
Objective: This study was performed to determine whether neoadjuvant treatment increases survival in patients with BRPC. Summary Background Data: Despite many promising retrospective data on the effect of for borderline resectable pancreatic cancer (BRPC), no high-level evidence exists support role such treatment. Methods: phase 2/3 multicenter randomized controlled trial designed enroll 110 BRPC who were randomly assigned gemcitabine-based chemoradiation (54 Gray external beam radiation)...
Plant growth promoting rhizobacteria (PGPR) are diverse, naturally occurring bacteria that establish a close association with plant roots and promote the immunity of plants. Established mechanisms involved in PGPR-mediated promotion include regulation phytohormones, improved nutrient availability, antagonistic effects on pathogens. In this study, we isolated bacterium from rhizospheric soil soybean field Chungcheong buk-do, South Korea. Using 16S rRNA sequencing, was identified as Bacillus...
Objective: To use the concept of benchmarking to establish robust and standardized outcome references after pancreatico-duodenectomy (PD). Background: Best achievable results PD are unknown. Consequently, comparisons among different cohorts, centers or with novel surgical techniques remain speculative. Methods: This multicenter study analyzes consecutive patients (2012–2015) undergoing in 23 international expert pancreas surgery. Outcomes without significant comorbidities major vascular...
The utilization of plant growth-promoting microbes is an environment friendly strategy to counteract stressful condition and encourage plants tolerance. In this regards, the current study was designed isolate ACC deaminase indole-3-acetic acid (IAA) producing halotolerant bacteria promote tomato (Solanum lycopersicum L.) growth tolerance against salinity stress.The selected bacterial MO1 identified as Leclercia adecarboxylata IAA quantification results revealed that produced significant...
Objective: The aim of this study was to define robust benchmark values for the surgical treatment perihilar cholangiocarcinomas (PHC) enable unbiased comparisons. Background: Despite ongoing efforts, postoperative mortality and morbidity remains high after complex liver surgery PHC. Benchmark data best achievable results in PHC are however still lacking. Methods: This analyzed consecutive patients undergoing major 24 high-volume centers 3 continents over recent 5-year period (2014–2018) with...
Abstract Background Benefits of neoadjuvant treatment for pancreatic cancer with major vessel invasion has been demonstrated through randomized controlled trials; however, the optimal strategy remains controversial, especially radiotherapy. Therefore, we aimed to evaluate efficacy and safety radiotherapy followed by chemotherapy time interval undergo surgery after in (borderline) resectable cancer. Methods Between 2013 2022, patients contact who received 5-fluorouracil leucovorin,...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor prognosis, largely due to the rapid development of chemoresistance in patients. Mitochondrial dynamics play crucial role cell survival. Currently, specific mechanisms underlying gemcitabine resistance PDAC remain unknown. In this study, we identified sodium/myo-inositol co-transporter solute carrier family 5 member 3 (SLC5A3) as key modulator promoting PDAC. SLC5A3 levels were significantly upregulated...
Current approaches to access control on the Web servers do not scale enterprise-wide systems because they are mostly based individual user identities. Hence we were motivated by need manage and enforce strong efficient RBAC technology in large-scale environments. To satisfy this requirement, identify two different architectures for Web, called user-pull server-pull . demonstrate feasibility, implement each architecture integrating extending well-known technologies such as cookies, X.509,...
As a result of climate change, crops often experience high-temperature stress that can drastically hinder plant growth and development. In soybean, an economically important crop is highly sensitive to heat stress, the use growth-promoting rhizobacteria (PGPRs) represents promising strategy for countering negative effects stress. Accordingly, novel strain Bacillus tequilensis (i.e. SSB07) grows actively at high temperatures was isolated, identified, characterized in present study. SSB07...
The rate of postoperative pancreatic fistula (POPF) after distal pancreatectomy ranges from 13% to 64%. To prevent POPF, polyglycolic acid (PGA) mesh was introduced, but its effect has been evaluated only in small numbers patients and retrospective studies.To evaluate the efficacy PGA preventing POPF pancreatectomy.Prospective randomized clinical, single-blind (participant), parallel-group trial at 5 centers between November 2011 April 2014. parenchyma divided using a stapling device; no...
Chemotherapy may negatively affect nutritional status and quality of life (QOL) in pancreatic cancer patients. Our aim was to investigate the beneficial effects oral nutrition supplements (ONS) on bile duct patients undergoing chemotherapy. Among with progressive receiving chemotherapy, ONS group (n = 15) received two packs daily for 8 weeks while non-ONS 19) did not. Anthropometric measures, dietary intake, status, were assessed. significantly increased intakes energy, carbohydrates,...
Plant growth-promoting rhizobacteria (PGPR) colonize plant roots, establish a mutualistic relationship with the plants and help them grow better. This study reports novel findings on effects of PGPR
Purpose: The surgical robotic system is superior to traditional laparoscopy in regards 3-dimensional images and better instrumentations.Robotic surgery for hepatic resection has not yet been extensively reported.Patients Methods: Between March May 2007, we performed 3 robot-assisted left lateral sectionectomies of the liver.Case 1 had a hepatocellular carcinoma (HCC), case 2 colon cancer with liver metastasis, intrahepatic duct stones.Results: All patients successful operation recovered...
The objective of this study was to identify prognostic factors for survival in patients with primary diffuse large B-cell lymphoma (DLBCL) the adrenal gland. Thirty one diagnosed DLBCL from 14 Korean institutions and treated R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine prednisone) were analyzed. Complete remission (CR) overall response rate after chemotherapy 54.8% 87.0%. 2-year estimates (OS) progression-free (PFS) 68.3% 51.1%. In achieving CR, significant prolongations OS...
Practical Guidelines for the Surgical Treatment of Gallbladder CancerAt present, surgical treatment is only curative option gallbladder (GB) cancer.Many efforts therefore have been made to improve resectability and survival rate.However, GB cancer has a low incidence, no randomized, controlled trials conducted establish optimal modalities.The present guidelines include recent recommendations based on current understanding highlight controversial issues that require further research.For T1a...
Objective: The aim of this study was to establish clinically relevant outcome benchmark values using criteria for pancreatoduodenectomy (PD) with portomesenteric venous resection (PVR) from a low-risk cohort managed in high-volume centers. Summary Background Data: PD PVR is regarded as the standard care patients cancer involvement axis. There are, however, no indicators population which hampers comparisons undergoing and without resection. Methods: This multicenter analyzed any type 23...
Pancreatic cancer is characterized by a poor prognosis, with its five-year survival rate lower than that of any other type. Gemcitabine, standard treatment for pancreatic cancer, often has outcomes patients as result chemoresistance. Therefore, novel therapeutic targets must be identified to overcome gemcitabine resistance. Here, we found SLC38A5, glutamine transporter, more highly overexpressed in gemcitabine-resistant gemcitabine-sensitive patients. Furthermore, the deletion SLC38A5...
Abstract Introduction We report our experience with laparoscopic major liver resection in Korea based on a multicenter retrospective study. Materials and methods Data from 1,009 resections conducted 2001 to 2011 were retrospectively collected. Twelve tertiary medical centers specialized hepatic surgeons participated this Results Among resections, performed 265 patients as treatment for hepatocellular carcinoma, metastatic tumor, intrahepatic duct stone, other conditions. The most frequently...
The benefits of early enteral feeding (EEN) have been demonstrated in gastrointestinal surgery.But, the impact EEN has not elucidated yet.We assessed postoperative nutritional status patients who had undergone pancreaticoduodenectomy (PD) according to method and compared clinical outcomes two methods.A prospective randomized trial was undertaken following PD.Patients were randomly divided into groups; group received feed control total parenteral nutrition (TPN) management.Thirty-eight...
We performed a prospective, multicenter, randomized controlled study to investigate the clinical outcomes, including postoperative pancreatic fistulas (POPF), after using TachoSil® patch in distal pancreatectomy (NCT01550406).Between June 2012 and September 2014, 101 patients at five centers were into Control (n = 53) TachoSil 48) groups. In all patients, pancreas was resected stapler with Endo-GIA™ staples. The wrapped around stump only group, not group.The patient characteristics, age...