A5100770744- Endometrial and Cervical Cancer Treatments
- Ovarian cancer diagnosis and treatment
- Cervical Cancer and HPV Research
- Uterine Myomas and Treatments
- Neuroendocrine Tumor Research Advances
- Lung Cancer Research Studies
- Colorectal and Anal Carcinomas
- Aging and Gerontology Research
- Sports Performance and Training
- Traffic Prediction and Management Techniques
- Stroke Rehabilitation and Recovery
- Diverse Topics in Contemporary Research
- Health disparities and outcomes
- BRCA gene mutations in cancer
- Diverse Approaches in Healthcare and Education Studies
- Health and Wellbeing Research
- Sports injuries and prevention
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Abdominal Surgery and Complications
- Ectopic Pregnancy Diagnosis and Management
- Intergenerational Family Dynamics and Caregiving
- PARP inhibition in cancer therapy
- Healthcare Education and Workforce Issues
- Thermoregulation and physiological responses
Deleted Institution
2009-2025
University of Ulsan
2007-2025
Asan Medical Center
2005-2025
Ulsan College
2015-2025
Yonsei University
2018-2025
Seoul National University
2006-2024
Yeungnam University
2007-2024
Gangnam Severance Hospital
2023
GTx (United States)
2023
Ulsan University Hospital
2023
Abstract Purpose: Castration-resistant prostate cancer (CRPC) may occur by several mechanisms including the upregulation of androgen receptor (AR), coactivators, and steroidogenic enzymes, aldo keto reductase 1C3 (AKR1C3). AKR1C3 converts weaker 17-keto androgenic precursors to more potent 17-hydroxy androgens is consistently major upregulated gene in CRPC. The studies manuscript were undertaken examine role AR function Experimental Design: LNCaP cells stably transfected with VCaP...
Aims Japan and Korea are the world's most aged rapidly aging nations. They both have low fertility rates, thereby intensifying importance of social structures to aid a large, dependent population older adults. Common strategies involve improving their participation, which enhances physical mental health, so they supporting society rather than being supported. Since participation rates in countries not as high those Western countries, it is critical shed light on factors related elderly....
To investigate the real-world efficacy and toxicity of paclitaxel-cisplatin-bevacizumab identify prognostic factors for in platinum-naïve primary stage IVB cervical cancer. We retrospectively reviewed patients with cancer who received as first-line treatment between July 2015 December 2021 at Asan Medical Center, Korea. Patient data including clinicopathologic characteristics, imaging, administration, recurrence, survival were collected. Overall, 61 included this study. The median age was 56...
Because of the nature their work, physical and occupational therapists are at high risk burnout, which is associated with decreased job satisfaction, medical errors, mental wellbeing in healthcare professionals. To well manage minimize potential impact factors should be determined. This study examined burnout stress various Korean hospital settings. Physical from several rehabilitation facilities South Korea completed a survey between March–May 2019. A set questionnaires, including Maslach...
Objectives:The aim of this study was to develop a new prognostic classification for epithelial ovarian cancer (EOC) patients using gradient boosting (GB) and compare the accuracy model with conventional statistical method.Methods: Information EOC from Samsung Medical Center (training cohort, n=1,128) analyzed optimize GB.The performance final externally validated patient information Asan (validation n=229).The area under curve (AUC) by GB compared that Cox proportional hazard regression...
Pancreatic cancer is characterized by a poor prognosis, with its five-year survival rate lower than that of any other type. Gemcitabine, standard treatment for pancreatic cancer, often has outcomes patients as result chemoresistance. Therefore, novel therapeutic targets must be identified to overcome gemcitabine resistance. Here, we found SLC38A5, glutamine transporter, more highly overexpressed in gemcitabine-resistant gemcitabine-sensitive patients. Furthermore, the deletion SLC38A5...
Lymph node metastasis is a significant predictive factor for disease recurrence and survival in cervical cancer patients. Given the importance of lymph metastasis, it imperative that patients harboring are identified can undergo appropriate treatment. Sentinel (SLN) mapping has drawn attention as technique. We evaluated feasibility efficacy using indocyanine green (ICG) cancer. performed single-center, retrospective study 103 surgically treated who underwent SLN mapping. After ICG to detect...
The Korean Society of Gynecologic Oncology has updated its clinical practice guidelines for endometrial cancer to incorporate advancements in recent high-quality randomized controlled trials. These address evolving treatment paradigms, and are tailored the medical context. Key updates include a strong recommendation doxorubicin/trabectedin combination therapy metastatic or recurrent unresectable leiomyosarcoma based on significant survival benefits demonstrated trial. For advanced cancer,...
Abstract Pancreatic cancer is an aggressive disease with low survival and high recurrence rates. A major obstacle in treating pancreatic the frequent development of chemoresistance to standard therapeutic drug, gemcitabine. One mechanism by which develops through proliferation stem cells (CSC). However, mechanisms regulating stemness chemoresistant tumors remain unclear. Here, we found that expression transcription factor Forkhead Box P1 (FOXP1) was elevated crucial for establishing CSC...
Direct-acting antivirals (DAAs) are highly effective in treating hepatitis C virus (HCV) infection. The long-term hepatic and extrahepatic outcomes of DAAs chronic (CHC) patients receiving curative elusive. CHC were retrieved from two phase III sofosbuvir-based clinical trials conducted 2013-2014. Patients who achieved a sustained virological response have been followed prospectively for 5 years since 2016. A propensity score-matched interferon-based historical control with 1:3 ratio was...
Induction of antigen-specific T cell tolerance would aid treatment diverse immunological disorders and help prevent allograft rejection graft versus host disease. In this study, we establish a method inducing in situ diabetic humanized mice Rhesus monkeys receiving porcine islet xenografts. Antigen-specific is induced by administration an antibody ligating particular epitope on ICAM-1 (intercellular adhesion molecule 1). Antibody-mediated ligation dendritic cells (DCs) led to the arrest DCs...
Abstract Although STK11 (LKB1) mutation is a major mediator of lung cancer progression, targeted therapy has not been implemented due to mutations being loss-of-function. Here, we report that targeting the Na + /K -ATPase (ATP1A1) synthetic lethal with in cancer. The cardiac glycosides (CGs) digoxin, digitoxin and ouabain, which directly inhibit ATP1A1 function, exhibited selective anticancer effects on mutant cell lines. Restoring function reduced efficacy CGs. Clinically relevant doses...
To support the implementation of individualized disease management, we aimed to develop machine learning models predicting platinum sensitivity in patients with high-grade serous ovarian carcinoma (HGSOC). We reviewed medical records 1002 eligible patients. Patients’ clinicopathologic characteristics, surgical findings, details chemotherapy, treatment response, and survival outcomes were collected. Using stepwise selection method, based on area under receiver operating characteristic curve...
Background: Sentinel lymph node (SLN) mapping has been suggested as an alternative surgical technique to full lymphadenectomy for early-stage endometrial cancer.However, the survival outcomes of SLN compared with have not established via a prospective study.Methods: A multi-center, single-blind, randomized controlled trial designed determine prognostic value alone conventional patients clinical stage I-II cancer.Eligible participants will be randomly assigned in 1:1 ratio between group...
The aim of the study were to identify risk factors for recurrent vaginal intraepithelial neoplasia (VaIN)1+ and evaluate efficacy laser vaporization in patients who underwent hysterectomy treatment cervical (CIN).Medical records 374 women CIN retrospectively reviewed. Recurrence was defined as VaIN1+ diagnosis by colposcopy-directed biopsy.Among patients, 36 (9.6%) had during a median follow-up 32 (0-193) months: 13 (3.5%) VaIN1, 6 (1.6%) VaIN2, 15 (4.0%) VaIN3, 2 (0.5%) invasive cancer....
Purpose Discovery of models predicting the exact prognosis epithelial ovarian cancer (EOC) is necessary as first step implementation individualized treatment. This study aimed to develop nomograms treatment response and in EOC. Materials Methods We comprehensively reviewed medical records 866 patients diagnosed with treated for EOC at two tertiary institutional hospitals between 2007 2016. Patients' clinico-pathologic characteristics, details primary treatment, intra-operative surgical...
Objectives: To determine the effectiveness of computer-assisted cognitive rehabilitation and compare patterns function recovery occurring in both traumatic brain injury (TBI) stroke. Methods: A total 62 patients were finally enrolled, consisting 30 with TBI 32 The received sessions (Comcog) five times per week. Each session lasted for min. Before immediately after rehabilitation, all evaluated by computerized neuropsychological test (CNT), Mini-Mental State Examination (MMSE), modified...
In this paper, the aerobic biodegradation behavior of nonylphenol polyethoxylates (NPnEOs) with ethoxy (EO) units specific lengths, which were fractionated using high-performance liquid chromatography(HPLC) photodiode array detection, was studied in presence different types organic materials. NPnEOs and their related metabolites under a modified OECD 301E test monitored chromatography/mass spectrometry (LC/MS) gas (GC/MS). Biodegradation tests matters, such as methanol, glucose, yeast...
Wilson's disease (WD), an autosomal recessive disorder of copper transport, is one the most common inherited metabolic disorders in Korea. Despite its frequency, incidence and carrier frequency WD has not yet been estimated Korean population. We therefore screened for four major missense mutations (p.Arg778Leu, p.Ala874Val, p.Leu1083Phe, p.Asn1270Ser) ATP7B gene 476 newborn filter papers by real-time multiplex PCR melting curve analysis using SYBR Green intercalator method based on...
Key molecular players that link inflammation to carcinogenesis are prostaglandins, cytokines, nuclear factor-κB (NF-κB), chemokines, angiogenic growth factors, and free radicals, all of which lead increased mutations altered functions important enzymes proteins, for example, activation oncogenic products and/or inhibition tumor suppressor in inflamed tissues, thus contributing multi-stage process. Interpreted reversely, the identification mechanisms by chronic increases cancer risk or...