A5086366354- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Renal cell carcinoma treatment
- Gallbladder and Bile Duct Disorders
- Hepatitis B Virus Studies
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis C virus research
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Animal Virus Infections Studies
- Cleft Lip and Palate Research
- Protease and Inhibitor Mechanisms
- Neurofibromatosis and Schwannoma Cases
- Colorectal Cancer Surgical Treatments
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Diabetes and associated disorders
- Cardiac Structural Anomalies and Repair
- Peptidase Inhibition and Analysis
- Thyroid Cancer Diagnosis and Treatment
Seoul National University
2021-2025
Seoul National University Hospital
2020-2025
Seoul Medical Center
2009
Abstract Background Benefits of neoadjuvant treatment for pancreatic cancer with major vessel invasion has been demonstrated through randomized controlled trials; however, the optimal strategy remains controversial, especially radiotherapy. Therefore, we aimed to evaluate efficacy and safety radiotherapy followed by chemotherapy time interval undergo surgery after in (borderline) resectable cancer. Methods Between 2013 2022, patients contact who received 5-fluorouracil leucovorin,...
Importance Despite the increasing prevalence of intraductal papillary mucinous neoplasm (IPMN), data on growth and malignant conversion rates based long-term surveillance cohorts are limited. Many international guidelines recommend for benign lesions, but optimal interval duration unclear. Objective To determine protocol IPMN propose which patients may be exempted from surveillance. Design, Setting, Participants This large-scale, cohort study examined 3825 with treated at 5 tertiary...
Background: Pancreatic cancer is a highly aggressive malignancy with poor prognosis. Neoadjuvant chemotherapy (NAC) increasingly used to improve survival in patients pancreatic cancer; however, it often results nutritional deterioration, which may negatively impact patient outcomes. Therefore, this study aimed assess the effect of changes status on long-term outcomes who underwent curative surgery after NAC. Methods: This retrospective single-center included 148 NAC between 2010 and 2020....
Abstract Background With the evolving treatment paradigms for pancreatic cancer, there is an increasing need reliable markers to evaluate effectiveness of preoperative chemotherapy. Due limitations current indicators, this study aimed prognostic value metabolic response based on changes in maximum standardized uptake (SUV max ) fluorine‐18‐fluorodeoxyglucose positron emission tomography. Methods This included 210 patients with cancer who underwent post‐chemotherapy curative surgery between...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor prognosis, largely due to the rapid development of chemoresistance in patients. Mitochondrial dynamics play crucial role cell survival. Currently, specific mechanisms underlying gemcitabine resistance PDAC remain unknown. In this study, we identified sodium/myo-inositol co-transporter solute carrier family 5 member 3 (SLC5A3) as key modulator promoting PDAC. SLC5A3 levels were significantly upregulated...
The aim was to build a calculator for personalized surveillance of BD-IPMNs. interval time low-risk branch duct intraductal papillary mucinous neoplasms (BD-IPMNs) has not been established yet. study included an international cohort BD-IPMNs without worrisome features (WFs) or high-risk stigmata (HRS). IPMN evolution defined as the occurrence HRS WFs. derivation comprised 60% patients. validation group remaining A parametric survival model developed in using Akaike (AIC) and Bayesian (BIC)...
Objective: To evaluate the prognostic impact of resection margin in distal cholangiocarcinoma (dCC). Background: Due to relatively low prevalence dCC Western countries and use various definitions status, bile duct status remains unclear. Methods: This study included consecutive patients who underwent curative surgery were diagnosed with between 2000 2022. Bile was classified as clear margin, low-grade dysplasia (LGD), high-grade (HGD), tumor present. Results: Of 587 patients, 506 (86.2%), 17...
Abstract Pancreatic cancer is an aggressive disease with low survival and high recurrence rates. A major obstacle in treating pancreatic the frequent development of chemoresistance to standard therapeutic drug, gemcitabine. One mechanism by which develops through proliferation stem cells (CSC). However, mechanisms regulating stemness chemoresistant tumors remain unclear. Here, we found that expression transcription factor Forkhead Box P1 (FOXP1) was elevated crucial for establishing CSC...
Introduction: The applicability of neoadjuvant treatment (NAT) for resectable pancreatic ductal adenocarcinoma (PDAC) has arisen, however, high-level evidence is lacking. This study aimed to explore patient subgroups with high-risk PDAC selecting candidates who may benefit from NAT. Methods: 1,132 patients or borderline underwent surgery between 2007 and 2021 were retrospectively reviewed. Patients without contact major vessels (R-no contact) (n=651), portal vein superior mesenteric (PV/SMV)...
Recurrence can still occur even after radical resection of stage I colorectal cancer (CRC). This study aimed to identify subgroups with a high risk for recurrence in the CRC. We retrospectively reviewed prospectively collected data 1952 patients CRC between 2002 and 2017 at our institute. 1398 (colon, 903 (64.6%), rectum, 495 (35.4%)) were eligible analysis. analyzed factors survival. During follow-up period (median: 59 months), 63 (4.6%) had recurrence. The rate rectal was significantly...
Abstract Background Neoadjuvant treatment (NAT) is standard for borderline resectable pancreatic cancer (BRPC). However, consensus lacking on the optimal surgical timing patients with BRPC undergoing NAT. The aim of this study was to investigate long‐term outcomes NAT and suggest resection timing. Methods Prospectively collected data 282 between January 2007 December 2019 were retrospectively reviewed. There 164 who underwent followed by surgery, 45 chemotherapy only, 73 upfront surgery....
Background: R0 rates have increased as neoadjuvant treatment (NAT) has become the primary for pancreatic ductal adenocarcinoma (PDAC) with venous involvement, suggesting a decrease in tumor infiltration. The aim of this study was to investigate clinical outcomes preserving portal/superior mesenteric vein (PV/SMV) during pancreaticoduodenectomy (PD) PDAC patients who underwent NAT. Material and Methods: 113 resectable borderline involvement responded NAT curative PD between 2012 2022 were...
Abstract Background Thoracic epidural analgesia (TEA), once the standard for pain management in major abdominal operations, is associated with postoperative complications, making preperitoneal continuous wound infiltration (CWI) a promising alternative. This study aimed to compare effectiveness of CWI and TEA managing after open pancreatoduodenectomy. Methods In single-centre, randomized, open-label non-inferiority trial, adult patients undergoing elective pancreatoduodenectomy were assigned...
In an era of more effective chemotherapy for pancreatic ductal adenocarcinoma (PDAC), the paradigm local treatment is changing. However, efficacy in patients with isolated liver metastasis remains unclear. Therefore, we aimed to evaluate effectiveness pancreatectomy ± (cytoreductive surgery) PDAC synchronous metastasis.In total, 239 were extracted from Seoul National University Hospital (SNUH). For comparison, another 12 637 Cancer Database (NCDB). Propensity score matching was performed...
Surgical indications of main duct-involved intraductal papillary mucinous neoplasm (IPMN), especially for pancreatic duct (MPD) 5-9 mm, remain controversial. We aimed to predict malignancy risk IPMN.Total 258 patients with IPMN between 2000 and 2017 in our institute were retrospectively analyzed. Main was classified into segmental diffuse-type by dilated MPD pattern. Clinicopathologic features predictive factors analyzed.Among patients, 47 211 had pure (segmental: 27, diffuse type: 20) mixed...
Abstract Background Although attempts of local treatment for isolated liver recurrence in patients with pancreatic ductal adenocarcinoma (PDAC) have increased, the efficacy remains unclear. Therefore, we aimed to evaluate effect recurrent lesions after pancreatectomy on survival PDAC. Methods Patients who were diagnosed at a high‐volume center included. We classified these based options and performed propensity score matching minimize confounding. Results Median interquartile range was...