A5080466465- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Esophageal and GI Pathology
- Biliary and Gastrointestinal Fistulas
- Gastrointestinal disorders and treatments
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Renal cell carcinoma treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Video Coding and Compression Technologies
- Gastrointestinal Tumor Research and Treatment
- Image and Video Quality Assessment
- Venous Thromboembolism Diagnosis and Management
- Inflammatory Biomarkers in Disease Prognosis
- Liver Diseases and Immunity
- Gastrointestinal Bleeding Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
Seoul National University Hospital
2016-2025
Seoul National University
2016-2025
National University College
2016-2025
New Generation University College
2009-2025
Diabetes Australia
2024
Hypertension Institute
2024
RELX Group (Netherlands)
2019-2023
German Cancer Research Center
2022
Heidelberg University
2022
Deutschen Konsortium für Translationale Krebsforschung
2022
OBJECTIVES: The goal of the study was to determine whether endoscopic ultrasound (EUS)-guided biliary drainage (EUS-BD) is comparable conventional transpapillary stenting with retrograde cholangiopancreatography (ERCP) in palliation malignant distal obstruction. Although ERCP for obstruction standard care, post-procedure pancreatitis and stent dysfunctions are not uncommon. While EUS-BD has garnered interest as a viable alternative when impossible, its role primary yet be proven. METHODS: We...
EUS-guided biliary drainage (EUS-BD) has been proposed as an alternative for patients after failed ERCP. To date, the evaluation of dedicated device one-step EUS-BD limited. determine feasibility and safety a newly designed 7F stent introducer with tapered metal tip push-type dilator placement without additional fistula dilation in EUS-BD.Thirty-two malignant obstruction ERCP were randomly assigned to modified hybrid (DH group, n = 16) or conventional 8.5F fully covered (FC 16). The...
Abstract Background Sarcopenia or visceral adipose tissue has been reported to be related pancreatic cancer prognosis. However, clinical relevance of the comprehensive analysis body compositions and their longitudinal changes is lacking. This study analysed association between composition after chemotherapy survival in patients with metastatic cancer. Methods We retrospectively included 456 (mean age ± standard deviation, 61.2 10.0 years; 272 males 184 females) who received palliative from...
Abstract Background and study aims The present aimed to determine the type of intravenous hydration that is best suited reducing incidence post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Patients methods In a prospective randomized multicenter trial, average-to-high risk patients who underwent first-time ERCP were randomly assigned three groups (1:1:1) received: aggressive (3 mL/kg/h during ERCP, 20-mL/kg bolus 3 for 8 hours after ERCP) with either lactated Ringer’s...
// Joo Kyung Park 1, * , Woo Hyun Paik 2, Kyoungbun Lee 3, Ji Kon Ryu 2 Sang Hyub and Yong-Tae Kim 1 Division of Gastroenterology, Department Medicine, Samsung Medical Center, Sungkyunkwan University School Seoul, Korea Internal Medicine Liver Research Institutute, Seoul National Hospital, College 3 Pathology, These authors contributed equally to this work Correspondence to: Ryu, email: jkryu@snu.ac.kr Keywords: DAXX/ATRX, MEN, neuroendocrine tumor Received: April 30, 2016 Accepted: May 01,...
deploying the metal stent inside a bile duct (half of stent) under EUS and fluoroscopic guidance gently pulling echoendoscope after full deployment channel (remaining portion guidance.This cohort was compared with matched historical cohort. RESULTS:In phase Ⅰ, technical clinical success modified method 96% (27/28) 89% (24/27 as per-protocol analysis).The overall adverse event rate 7%.In Ⅱ, there no difference in success, patency events each group.However, procedural time (15.3 ± 5.2 min vs...
The strategy for treating small borderline malignant pancreatic neoplasms—such as neuroendocrine tumor (NET) and solid pseudopapillary neoplasm (SPN)—is surgical resection. However, resection of these lesions still causes significant morbidity. We evaluated the safety efficacy EUS-guided ethanol ablation to treat neoplasms. A total 8 patients with neoplasms co-morbidities who refused surgery were included. identified 2 cases nonfunctioning NET, 3 insulinomas, 1 case gastrinoma, SPN. was...
Endoscopic ultrasonography-guided ethanol ablation therapy for pancreatic cystic lesions is a minimally invasive treatment but still an experimental therapy. The aims were to investigate the safety and efficacy of endoscopic therapy.The inclusion criteria following: clinically indeterminate in radiologic imaging studies, 2 5 cm unilocular or oligolocular cysts without communication main duct, patients with high-risk operation.There 91 study median follow-up 40 months. response rate was as...
Lymph-node (LN) metastasis is an important prognostic factor in resected pancreatic cancer. In this study, the value of American Joint Committee on Cancer (AJCC) 8th edition N stage, lymph-node ratio (LNR), and log odds positive lymph nodes (LODDS) cancer was investigated.Between January 2005 December 2017, there were 351 patients with treated R0 resection adjuvant therapy at Seoul National University Hospital. Relationships between three LN parameters overall survival (OS) recurrence-free...
Abstract Background FOLFIRINOX (FFX) and Gemcitabine plus nab-paclitaxel (GnP) have been recommended as the first-line chemotherapy for metastatic pancreatic cancer (mPC). However, evidence is lacking comparing not only two regimens, but also sequential treatment (FFX–GnP vs. GnP–FFX). Methods Data of 528 patients (FFX, n = 371; GnP, 157) with mPC were collected retrospectively. Propensity score matching was conducted to alleviate imbalance groups. Overall survival (OS), progression free...
Goals: The aim of this study was to evaluate the adequacy and diagnostic yield histologic core obtained with a 22 G endoscopic ultrasound histology needle using capillary sampling stylet slow-pull technique without on-site cytopathologist. Background: No standard for new EUS has been established. Study: A total 125 consecutive patients intra-abdominal solid masses were enrolled prospectively between October 2011 March 2013. EUS-guided fine biopsy (EUS-FNB) performed. Results: 133 EUS-FNB...
Monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte (NLR), and platelet-to-lymphocyte (PLR) have been reported to be prognostic markers in various cancers. However, the value of these inflammatory biomarkers, particularly MLR, gallbladder cancer remains determined.From 2005 2016, 178 patients with histologically confirmed adenocarcinoma who underwent palliative chemotherapy were queried this study. The association between survival clinical laboratory variables, including NLR, PLR,...
Familial adenomatous polyposis (FAP) is a rare inherited syndrome that predisposes the patient to cancer. Treatment of FAP-related ampullary lesions challenging and role endoscopic papillectomy has not been elucidated. We retrospectively analyzed outcomes in matched cohorts sporadic (SALs).This retrospective multicenter study included 1422 procedures. Propensity score matching including age, sex, comorbidity, histologic subtype, size was performed. Main were complete resection (R0),...
Pancreatic cancer is characterized by fibrosis/desmoplasia in the tumor microenvironment, which primarily mediated pancreatic stellate cells and cancer-associated fibroblasts. HGF/c-MET signaling, instrumental embryonic development wound healing, also implicated for its mitogenic motogenic properties. In cancer, this pathway, along with downstream signaling pathways, associated disease progression, prognosis, metastasis, chemoresistance, other tumor-related factors. Other features of...
Abstract Management of hemobilia is often challenging. Recently, endoscopic hemostasis with a self-expandable metal stent (SEMS) has shown promising efficacy for controlling bleeding at the sphincterotomy site. This study aimed to assess and feasibility as bridge therapy hemobilia. Patients between 2008 2023 were retrospectively reviewed. We compared initial group (ENDO group) angiographic embolization (EMBO group). The primary outcome was success rate secondary outcomes delayed rate,...