Asif Halimi
A5060489121- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Gut microbiota and health
- Vascular Malformations and Hemangiomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Central Venous Catheters and Hemodialysis
- Glioma Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Cancer Diagnosis and Treatment
- Colorectal and Anal Carcinomas
- Multiple and Secondary Primary Cancers
- Infections and bacterial resistance
- Protein purification and stability
- Antiplatelet Therapy and Cardiovascular Diseases
- Economic and Financial Impacts of Cancer
Umeå University
2020-2025
Karolinska Institutet
2017-2024
Karolinska University Hospital
2017-2023
KTH Royal Institute of Technology
2005
AlbaNova
2005
Antibody-based proteomics provides a powerful approach for the functional study of human proteome involving systematic generation protein-specific affinity reagents. We used this strategy to construct comprehensive, antibody-based protein atlas expression and localization profiles in 48 normal tissues 20 different cancers. Here we report new publicly available database containing, first version, ∼400,000 high resolution images corresponding more than 700 antibodies toward proteins. Each...
Objectives Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic cysts that can progress to invasive cancer. Associations between oncogenesis and oral microbiome alterations have been reported. This study aims investigate a potential intracystic in cystic neoplasm (PCN) surgery patient cohort. Design Paired cyst fluid plasma were collected at from patients with suspected PCN (n=105). Quantitative qualitative assessment of bacterial DNA by qPCR, PacBio sequencing (n=35), interleukin...
To investigate whether tangential versus segmental portomesenteric venous resection (PVR) impacts surgical and oncological outcome in patients undergoing pancreatoduodenectomy for pancreatic cancer with vein (PMV) involvement. Current comparative studies on PVR as part of include all degrees PMV involvement, including cases where may not be a feasible approach, limiting the clinical applicability. International retrospective study 10 centers from 5 countries, consecutive after ≤180°...
Few studies have investigated the outcome of pancreatectomy associated with artery resection (PAR).Retrospective analysis a cohort operated borderline or locally advanced pancreatic cancer patients surgically confirmed arterial involvement. Short and long-term were analyzed compared in who underwent PAR (Group 1) palliative surgery 2).Of 73 surgical exploration intent resection, 34 (±venous resection) 39 palliation 2). 23 (67.7%) Group 1 combined artery-vein (AVR). Operation time was longer...
<h3>Importance</h3> The benefit of adjuvant chemotherapy after resection pancreatic cancer following neoadjuvant combination treatment with folinic acid, fluorouracil, irinotecan, and oxaliplatin (FOLFIRINOX) is unclear. <h3>Objective</h3> To assess the association overall survival (OS) in patients FOLFIRINOX treatment. <h3>Design, Setting, Participants</h3> This international, multicenter, retrospective cohort study was conducted from January 1, 2012, to December 31, 2018. An existing...
Abstract Background Whether patients who undergo resection of ampullary adenocarcinoma have a survival benefit from adjuvant chemotherapy is currently unknown. The aim this study was to compare between with and without after in propensity score-matched analysis. Methods An international multicentre cohort conducted, including underwent pancreatoduodenectomy for 2006 2017, 13 centres six countries. Propensity scores were used match received those did not, the entire two subgroups...
The pancreas has two main functions: to produce and secrete digestive enzymes (exocrine function) hormones that regulate blood glucose splanchnic secretion (endocrine function). endocrine exocrine portions of the are central regulators in digestion metabolism, with continuous crosstalk between their deeply interconnected components, which plays a role disease. Pancreatic neoplasms, inflammation, trauma, surgery can lead development type 3c diabetes when an insult simultaneously damages both...
Intraoperative pancreatoscopy is a promising procedure that might guide surgical resection for suspected main duct (MD) and mixed type (MT) intraductal papillary mucinous neoplasms (IPMNs). The aim of the present study was to assess diagnostic yield clinical impact intraoperative in patients operated on MD MT-IPMNs. This retrospective cohort study. Patients undergoing surgery or MT-IPMN underwent frozen section analysis. In all who required extended due pancreatoscopic findings, we compared...
Emerging research suggests gut microbiome may play a role in pancreatic cancer initiation and progression, but cultivation of the remains challenging. This pilot study aims to investigate possibility cultivate from cystic lesions associated with invasive cancer. Intra-operatively acquired cyst fluid samples showed culture-positivity mainly intraductal papillary mucinous neoplasm (IPMN) group lesions. MALDI-TOF MS profiling analysis shows Gammaproteobacteria Bacilli dominate among individual...
Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, with a 5 year survival rate as low 9%. One factor complicating management pancreatic lack reliable tools for early diagnosis. While up to 50% adult population has been shown develop precancerous cysts, limited and insufficient approaches are currently available determine whether cyst going progress into cancer. Recently, we used metabolomics identify candidate markers disease progression in patients diagnosed...
Familial adenomatous polyposis (FAP) is a rare inherited syndrome that predisposes the patient to cancer. Treatment of FAP-related ampullary lesions challenging and role endoscopic papillectomy has not been elucidated. We retrospectively analyzed outcomes in matched cohorts sporadic (SALs).This retrospective multicenter study included 1422 procedures. Propensity score matching including age, sex, comorbidity, histologic subtype, size was performed. Main were complete resection (R0),...
Intraductal papillary mucinous neoplasms (IPMNs) are cystic precursor lesions to pancreatic cancer. The presence of oral microbes in tissue or cyst fluid has been associated with high-grade dysplasia (HGD) and present study aims at investigating if humoral immunity pancreas-associated reflects IPMN severity. Paired plasma (n = 109) saliva 65) samples were obtained from tumor cases controls, for anti-bacterial antibody analysis DNA quantification by enzyme-linked immunosorbent assay (ELISA)...
2017 International and 2018 European guidelines are the most recent for intraductal papillary mucinous neoplasms management.to evaluate diagnostic accuracy of these in identifying malignant IPMN.data from resected patients with IPMN were collected two referral centers. Features risk associated to cancerous degeneration described retrospectively applied. Sensitivity, specificity, positive negative predictive value detecting disease calculated.the study includes 627 patients. suggest resection...
Objective: To assess outcomes among patients undergoing total pancreatectomy (TP) including predictors for complications and in-hospital mortality. Background: Current studies on TP mostly originate from high-volume centers span long time periods therefore may not reflect daily practice. Methods: This prospective pan-European snapshot study included who underwent elective (primary or completion) in 43 16 European countries (June 2018–June 2019). Subgroup analysis cutoff values annual volume...
Preoperative FOLFIRINOX chemotherapy is increasingly administered to patients with borderline resectable (BRPC) and locally advanced pancreatic cancer (LAPC) improve overall survival (OS). Multicenter studies reporting on the impact from number of preoperative cycles use adjuvant in relation outcomes this setting are lacking. This study aimed assess outcome pancreatectomy after FOLFIRINOX, including predictors OS.This international multicenter retrospective cohort included 31 centers 19...
Objectives Most patients with pancreatic cancer who have undergone surgical resection eventually develop disease recurrence. This study aimed to investigate whether there is evidence support routine surveillance after surgery, a secondary aim of analyzing the implementation strategies in Nordic countries.
Background and aims: Chronic pancreatitis may cause intractable abdominal pain, with total pancreatectomy sometimes being the last resort. To mitigate subsequent diabetes, can be followed by islet autotransplantation (TP-IAT). The primary aim of this study was to assess outcomes in patients undergoing TP-IAT at Karolinska University Hospital respect safety, postoperative complications, graft function. A secondary compare liver skeletal muscle as sites. Methods: Single-center observational...
Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, with a 5-year survival rate as low 9%. One factor complicating management pancreatic lack reliable tools for early diagnosis. While up to 50% adult population has been shown develop precancerous cysts, limited and insufficient approaches are currently available determine whether cyst going progress into cancer. Recently, we used metabolomics identify candidate markers disease progression in patients diagnosed...