A5066592142- Genetics, Aging, and Longevity in Model Organisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Bone and Dental Protein Studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Breast Cancer Treatment Studies
- DNA Repair Mechanisms
- Colorectal Cancer Treatments and Studies
- Glutathione Transferases and Polymorphisms
- Estrogen and related hormone effects
- Colorectal Cancer Surgical Treatments
- Drug Transport and Resistance Mechanisms
- Pediatric Hepatobiliary Diseases and Treatments
- Biliary and Gastrointestinal Fistulas
- Anorectal Disease Treatments and Outcomes
- Lung Cancer Research Studies
- Melanoma and MAPK Pathways
- Cancer Genomics and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Gastric Cancer Management and Outcomes
- Pelvic floor disorders treatments
- Multiple and Secondary Primary Cancers
Umeå University
2016-2025
Inserm
2014-2023
Institut Gustave Roussy
2023
University Hospital of Umeå
2017
LBA4005 Background: Fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) has shown improved survival in metastatic pancreatic cancer, promising results as downstaging chemotherapy locally advanced cancer. The efficacy of neoadjuvant FOLFIRINOX patients with resectable cancer is unknown. Methods: This a randomized phase II trial included from 12 Nordic centers the period 2017-2021. Patients head were randomly assigned to receive either four cycles followed by surgery eight...
It is controversial whether division of the inferior mesenteric artery close to aorta influences risk anastomotic leakage, especially in elderly and unfit. This population-based study was carried out evaluate independent association between a high arterial ligation leakage anterior resection for rectal cancer.All patients who had cancer from 2007 2009 inclusive were identified Swedish Colorectal Cancer Registry. The tie evaluated logistic regression model, with adjustment confounders....
We previously identified osteopontin (OPN) as a promising marker for the early detection of hepatocellular carcinoma (HCC). In this study, we investigated association between prediagnostic circulating OPN levels and HCC incidence in large population-based cohort. A nested case-control study was conducted within European Prospective Investigation into Cancer Nutrition (EPIC) During mean follow-up 4.8 years, 100 cases were identified. Each case matched to two controls measured baseline plasma...
In vitro and animal studies suggest that bioactive constituents of coffee tea may have anticarcinogenic effects against cutaneous melanoma; however, epidemiological evidence is limited to date. We examined the relationships between (total, caffeinated or decaffeinated) consumption risk melanoma in European Prospective Investigation into Cancer Nutrition (EPIC). EPIC a multicentre prospective study enrolled over 500,000 participants aged 25–70 years from ten countries 1992–2000. Information...
Leakage of bacterial products across the gut barrier may play a role in liver diseases which often precede development cancer. However, human studies, particularly from prospective settings, are lacking. We used case-control study design nested within large cohort to assess association between circulating levels anti-lipopolysaccharide (LPS) and anti-flagellin immunoglobulin A (IgA) G (IgG) (reflecting long-term exposures LPS flagellin, respectively) risk hepatocellular carcinoma. total 139...
<p>Z-factors for automated scoring protocols in the ST65 strain.</p>
<p>Automated scoring of vulval induction and percent larvae in the ST65 strain.</p>
<p>Supplementary methods and figure legends</p>
<p>Supplementary table 1. All Compounds and Exclusions</p>
<p>Manual scoring of vulval induction in the ST65 strain.</p>
<p>Automated scoring of larvae in the ST65 strain.</p>
Background and Aims: Impaired blood perfusion may be implicated in anastomotic leakage after anterior resection for rectal cancer. We investigated whether high ligation of the inferior mesenteric artery or total mesorectal excision compromises visceral flow colonic limb stump, respectively. Material Methods: A prospective cohort study was conducted a university hospital setting. used Laser Doppler flowmetry to evaluate impact level tie on extent flow. In rectum, different quadrants were also...
Abstract Background Consistent data on clinical features, treatment modalities and long-term survival in patients with hepatocellular carcinoma (HCC) using nationwide quality registers are lacking. This study aimed to describe patterns outcomes diagnosed HCC a national maintained database. Methods Characteristics registered the register of liver bile duct tumours (SweLiv) between 2009 2016 were reviewed. Overall (OS) was estimated Kaplan–Meier analysis log rank test compare subgroups for...
There are several surgical options for the management of pilonidal disease, including midline and off closure, but prospective studies rare. The study hypothesis was that Karydakis flap surgery would result in shorter wound healing fewer recurrences than excision sinus suture midline.A randomized clinical trial conducted two hospitals Sweden between 2006 2015 to compare with surgery. Adult patients a chronic disease were 1:1 at outpatient clinic without blinding. Power calculation based on...
Abstract Purpose The aim was to investigate the pharmacokinetics of preoperatively administered intraperitoneal (IP) 5-FU in patients with resectable pancreatic ductal adenocarcinoma (PDAC) by analyzing levels and target metabolites peritoneal fluid, plasma, liver, lymph nodes, tumour, tissue. These results were correlated expression genes encoding enzymes pathway cell membrane transporters FdUMP. Methods Twenty-two PDAC treated IP before surgery. postoperative treatment followed a routine...
Cancer can be cured by platinum-based chemotherapy, but resistance is a major cause of treatment failure. Here we present the nematode Caenorhabditis elegans as model to study interactions between platinum drug cisplatin and signaling pathways in vivo. Null mutation single gene, asna-1, makes worms hypersensitive cisplatin. The metalloregulated ATPase ASNA-1 promotes insulin secretion membrane insertion tail-anchored proteins. Using structural data from homologues, identify specific mutants...
The benefit of liver resection or ablation for breast cancer metastases (BCLM) remains unclear. aim the study was to determine survival after isolated BCLM in nationwide cohorts and compare surgical versus systemic treatment regimens.The Swedish register bile ducts (SweLiv) National (NBCR) studied identify patients with 1-5 without extrahepatic spread diagnosed 2009-2016. Data from registers were validated completed by review medical records. A Kaplan-Meier plot log rank test used analyse...
Abstract Background Resection margin has been associated with overall survival following liver resection for colorectal metastasis. The aim of this study was to examine how margins 0.0 mm, 0.1–0.9 mm and ≥1 influence in patients resected metastasis a time modern perioperative chemotherapy surgery. Methods Using data from the national registries Swedish Colorectal Cancer Registry National Quality Liver, Bile Duct Gallbladder Cancer, that had resections between 2009 2013 were included. In...