A5017455729- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease and Transplantation
- Biliary and Gastrointestinal Fistulas
- Lung Cancer Treatments and Mutations
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Organ Transplantation Techniques and Outcomes
- Cancer Cells and Metastasis
- Clinical Nutrition and Gastroenterology
- Drug-Induced Hepatotoxicity and Protection
- Surgical Simulation and Training
- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Colorectal Cancer Screening and Detection
- Diverticular Disease and Complications
- Hepatitis C virus research
- Medical and Biological Sciences
- Appendicitis Diagnosis and Management
- Oral and Maxillofacial Pathology
Karolinska Institutet
2012-2024
Karolinska University Hospital
2008-2023
St Göran's Children's Hospital
2007
Saint Göran Hospital
2007
Christ Hospital
1993
Sahlgrenska University Hospital
1993
Colorectal cancer (CRC) is a leading cause of cancer-associated deaths with liver metastases developing in 25-30% those affected. Previous data suggest survival difference between right- and left-sided metastatic CRC, even though has higher incidence metastases. The aim the study was to describe patterns as function characteristics primary tumour different combinations disease.A retrospective population-based performed on cohort patients diagnosed CRC region Stockholm, Sweden during 2008....
<b>Objectives</b> To determine whether the routine use of intraoperative cholangiography can improve survival from complications related to bile duct injuries. <b>Design</b> Population based cohort study. <b>Setting</b> Prospectively collected data Swedish national registry gallstone surgery and endoscopic retrograde cholangiopancreatography, GallRiks. Multivariate analysis done by Cox regression. <b>Population</b> All cholecystectomies recorded in GallRiks between 1 May 2005 31 December...
Whether intraoperative cholangiography can prevent iatrogenic bile duct injury during cholecystectomy remains controversial.Data from the national Swedish Registry for Gallstone Surgery, GallRiks (May 2005 to December 2010), were analysed evidence of cholecystectomy. Patient- and procedure-related risk factors with a focus on rate intended using multivariable logistic regression.A total 51 041 cholecystectomies 747 injuries (1·5 per cent) identified; 9008 patients (17·6 diagnosed acute...
Background: Post-hepatectomy liver failure (PHLF) is considered a main reason for death after major hepatectomy. The reported PHLF-related mortality differs largely and the data mainly originate from single centers.Aim: A retrospective, population-based register study was designed to evaluate impact of PHLF on 90-day hepatectomy.Method: All patients who underwent resection in Sweden between 2005 2009 were retrospectively identified using Swedish Hospital Discharge Registry. 30- by linkage...
Approximately 25% of patients with colorectal cancer (CRC) will have liver metastases classified as synchronous or metachronous. There is no consensus on the defining time point for synchronous/metachronous, and prognostic implications thereof remain unclear. The aim study was to assess value differential detection at various points in a population-based patient cohort conduct literature review topic.All diagnosed CRC counties Stockholm Gotland, Sweden, during 2008 were included followed 5...
To determine whether the routine use of intraoperative cholangiography can improve survival from complications related to bile duct injuries.Population based cohort study.Prospectively collected data Swedish national registry gallstone surgery and endoscopic retrograde cholangiopancreatography, GallRiks. Multivariate analysis done by Cox regression.All cholecystectomies recorded in GallRiks between 1 May 2005 31 December 2010.Evidence injury, rate intended cholangiography, after...
Treatment of common bile duct stones has changed. Open surgery gradually been replaced by endoscopic and laparoscopic procedures. The aims this study were to see how have treated in Sweden, establish whether there differences morbidity mortality between these approaches, identify factors influencing mortality.All persons undergoing inpatient exploration or retrograde cholangiopancreatography (ERCP) during 1965-2009 the Swedish Hospital Discharge Registry, but without a diagnosis malignancy...
Abstract Background Assessing patients with colorectal cancer liver metastases (CRCLM) by a multidisciplinary team (MDT) results in higher resection rates and improved survival. The aim of this study was to evaluate the potentially rate defined cohort if all CRCLM were evaluated MDT. Patients Methods A retrospective analysis diagnosed during 2008 greater Stockholm region conducted. All (LM), detected 5-year follow-up, re-evaluated at fictive MDT which previous imaging studies, tumor...
The objectives of this study were to analyze the outcome after hepatectomy and identify contributing factors mortality long-term survival in a population-based setting.A retrospective, nationwide register was performed. All patients who underwent Sweden between 2002 2011 identified Swedish Hospital Discharge Registry using their unique personal identification numbers. This cohort linked National Cancer (cancer diagnosis), Causes Death, Migration Registry. Survival analysis by Kaplan-Meier...
Abstract Background Consistent data on clinical features, treatment modalities and long-term survival in patients with hepatocellular carcinoma (HCC) using nationwide quality registers are lacking. This study aimed to describe patterns outcomes diagnosed HCC a national maintained database. Methods Characteristics registered the register of liver bile duct tumours (SweLiv) between 2009 2016 were reviewed. Overall (OS) was estimated Kaplan–Meier analysis log rank test compare subgroups for...
The optimal treatment strategy for patients with synchronous colorectal liver metastases (CRLM) is unclear. aim of this study was to compare the outcome simultaneous, liver-first, and colorectal-first surgical approaches.All consecutive who had been resected curative intent CRLM were included. A Cox regression model constructed, an intention-to-treat analysis performed between liver-first simultaneous approaches, after propensity score matching.658 included in analysis. 92 a resection, 163...
Posthepatectomy liver failure (PHLF) represents the single most important cause of postoperative mortality after major resection, yet no effective treatment option is available. Extracorporeal support devices might be helpful, but systematic studies are lacking. Accordingly, we aimed to assess safety and feasibility Molecular Adsorbent Recirculating System (MARS) in patients with PHLF. Between December 2012 May 2015, a total 206 underwent or extended hepatectomy, 10 consecutive PHLF...
Liver metastases are the most common cause of death for patients with colorectal cancer and affect up to half patients. resection is an established method that can potentially be curative. For extrahepatic disease (EHD), role liver surgery less established.This a retrospective study based on data from national quality registry SweLiv. Data were obtained between 2009 2015. SweLiv validated has been in use since 2009, coverage above 95%. Patients EHD analyzed cross-checked against survival...
The aim was to assess the likelihood of patients with simultaneously diagnosed liver and lung metastases (SLLM) from colorectal cancer (CRC) receive curative treatment decided upon multidisciplinary team meeting (MDT) elaborate on reasons for intention failure survival outcomes depending final strategy.The study included a retrospective review all discussed at MDT single centre between 2010 2018 identify presenting SLLM CRC. Treatment intention, actual outcome documented. Descriptive...
Numerous studies have reported superior outcome for patients with hepatocellular carcinoma (HCC) in non-cirrhotic compared to cirrhotic livers. This cohort study aims describe the clinical presentation, disease course, treatment approaches, and survival differences a population-based setting.
Background and study aims: Elevated long-term risk of cholangiocarcinoma is reported after endoscopic sphincterotomy (ES), but in a previous we found trend towards decreased risk. The aim this was to evaluate the association larger cohort with longer follow-up. Patients methods: Data concerning all patients having had an inpatient retrograde cholangiopancreatography (ERCP) were collected from hospital discharge registries Finland Sweden. Incident cases malignancy identified through linkage...
Several existing scoring systems predict survival of patients with colorectal liver metastases. Many lack validation, rely on old clinical data, and have been found to be less accurate since the introduction chemotherapy. This study aimed construct validate a clinically relevant preoperative prognostic model for metastases.A predictive data available before surgery was developed. Survival analysed by Cox regression analysis, quality assessed using discrimination calibration. The validated...
The clinical importance of intraductal papillary mucinous neoplasm (IPMN) have increased last decades. Long-term survival after resection for invasive IPMN (inv-IPMN) compared to conventional pancreatic ductal adenocarcinoma (PDAC) is not thoroughly delineated.This study, based on the Swedish national and periampullary cancer registry aims elucidate outcome inv-IPMN PDAC.All patients ≥18 years age resected PDAC in Sweden between 2010 2019 were included. Clinicopathological variables...