A5064787448- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- Esophageal Cancer Research and Treatment
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Genetic factors in colorectal cancer
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Gallbladder and Bile Duct Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Galectins and Cancer Biology
- RNA modifications and cancer
- Genomic variations and chromosomal abnormalities
- Glycosylation and Glycoproteins Research
- Gastroesophageal reflux and treatments
- Inflammatory mediators and NSAID effects
- Gut microbiota and health
- Colorectal Cancer Treatments and Studies
- Renal cell carcinoma treatment
- Neuroendocrine Tumor Research Advances
University of Helsinki
2015-2025
Helsinki University Hospital
2016-2025
Oulu University Hospital
2024
Herttoniemi Hospital
2005
Translational Research Institute
2002
Jorvi Hospital
2000
National Cancer Center Hospital East
1998
Päijät-Hämeen Keskussairaala
1992
The oncological safety of minimally invasive surgery has been questioned for several abdominal cancers. Concerns also exist regarding the use distal pancreatectomy (MIDP) in patients with resectable pancreatic cancer as randomised trials are lacking.In this international non-inferiority trial, we recruited adults from 35 centres 12 countries. Patients were randomly assigned to either MIDP (laparoscopic or robotic) open (ODP). Both and pathologists blinded approach. Primary endpoint was...
Importance The effect of adjuvant chemotherapy following resection pancreatic adenocarcinoma after preoperative (m)FOLFIRINOX (combination leucovorin calcium [folinic acid], fluorouracil, irinotecan hydrochloride, and oxaliplatin in full or modified dosing) on overall survival (OS) is unclear because current studies do not account for the number cycles regimen. Objective To investigate association with OS, taking into Design, Setting, Participants This retrospective cohort study included...
Background: This endoscopic follow-up study was undertaken to evaluate the risk of gastric cancer (GC) and carcinoids in patients with pernicious anaemia (PA) analyse whether early detection GC could be provided by regular follow-up. Methods: Screening gastroscopy performed 71 anaemia, thereafter they were followed up gastroscopies at 3-year intervals for a mean time 5.8 years. Standardized incidence ratios (SIR) calculated, expected number being based on rates whole Finnish population....
Microbial ecosystems that inhabit the human gut form central component of our physiology and metabolism, regulating modulating both health disease. Changes or disturbances in composition activity this microbiota can result altered immunity, inflammation, even cancer. To compare diversity stool samples from patient groups based on site neoplasm gastrointestinal tract (GIT) to assess possible contribution bacterial tumorigenesis. We studied by16S RNA gene sequencing DNA 83 patients, who were...
Background . Only a few reported studies focus on the natural history and course of advanced severe chronic atrophic gastritis. Methods In this study we followed 47 men (mean age 62 years) with (moderate or severe) Helicobacter pylori ‐positive corpus Duration endoscopic follow‐up was 6 years based serum levels pepsinogen I antibodies to H. covered period 10 years. None patients treated for infection prior end follow‐up. Results The median antibody titre declined (IgG from 4000 1300; IgA 200...
Abstract Purpose: Cyclooxygenase-2 (COX-2) promotes carcinogenesis and its expression associates with clinicopathologic characteristics in gastric cancer. HuR is an mRNA binding protein that controls the stability of certain transcripts including COX-2. We evaluated prognostic significance COX-2 expressions cancer whether there exists a link between expressions. Experimental Design: The study included 342 consecutive patients histologically confirmed adenocarcinoma, whom 321 had tissue...
Abstract Background Highly utilized risk scores for clinically relevant postoperative pancreatic fistula (CR-POPF) have guided clinical decision-making in pancreatoduodenectomy. However, none has been successfully developed distal pancreatectomy. This study aimed to develop and validate a new score Methods Patients undergoing pancreatectomy at Helsinki University Hospital, Finland from 2013 2021, Karolinska Sweden, 2010 2020, were included retrospectively. The outcome was CR-POPF, according...
ABSTRACT Introduction The IMMray PanCan-d test combines an 8-plex biomarker signature with CA19-9 in a proprietary algorithm to detect pancreatic ductal adenocarcinoma (PDAC) serum samples. This study aimed validate the clinical performance of and better understand Lewis null (le/le) individuals who cannot express CA19-9. Methods Serum samples from 586 were analyzed assay, including 167 PDAC samples, 203 at high-risk for familial/hereditary 221 healthy controls. Samples collected eleven...
Background: There are few data on the natural course of Helicobacter pylori ‐related atrophic gastritis. Aim: To investigate effect H. eradication advanced gastritis in corpus. Methods: Twenty‐two elderly men with infection and moderate or severe corpus formed study population. These were under endoscopic surveillance because presence indefinite definite dysplastic gastric lesions addition to The gastroscopically bioptically examined four times before they received therapy (mean follow‐up...
AIMS: To assess the risk of gastric carcinoma in patients with histologically verified dysplasia and atrophic gastritis stomach. METHODS: One hundred one mild (n = 84), moderate 14), or severe 3) among 359 elderly men who smoked underwent gastroscopy because low serum pepsinogen. Patients were prospectively followed up for an average four years repeated gastroscopies multiple biopsies. RESULTS: Four 84 (4.8%) cases had progressed to during follow up. Most resolved spontaneously. No surgical...
The prognostic value of the immunohistochemical expression epithelial and stromal syndecan-1 was evaluated in 296 patients with gastric carcinoma. Formalin-fixed, paraffin-embedded specimens adenocarcinomas were stained mouse monoclonal antibody B-B4 against human syndecan-1. Loss immunoreactivity (≤60% cancer cells stained) observed 197 (67%) patients. Stromal 28 (9%) correlated a higher stage disease (stages II–IV), tumour location upper third stomach, nodal metastases (N1 or N2), positive...
We studied DNA copy number changes in gastric cancer (GC) using comparative genomic hybridization (CGH) analysis on 35 resected carcinomas (22 of the intestinal type and 13 diffuse type). Eighty-three percent cases showed changes. Gains were more common than losses (median 3 1 primary tumors type, respectively). The most gains detected 20q [46%; 12 (55%) four (31%)], 8q [37%; 10 (45%) three (23%)], 17q12-21 [29%; all but one (41%)]. frequent 18q [26%; (41%)] 4q [23%; (32%)]. High-level...
To elucidate gene expression signatures associated with gastric carcinogenesis, we performed a genome-wide analysis of 46 Finnish and 20 Japanese tissues. Comparative between datasets identified 58 common genes that were differentially expressed cancerous non-neoplastic Twenty-six these up-regulated in cancer 32 down-regulated. Of genes, 64% also another unrelated publicly available dataset. The levels four the CXCL1, SPARC, SPP1 SULF, further analyzed 82 tissues using quantitative real-time...
We have investigated the expression and regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in gastric cancer.Clinical adenocarcinoma samples were analyzed by immunohistochemistry quantitative real-time PCR for protein mRNA 15-PGDH methylation status promoter. The effects interleukin-1beta (IL-1beta) epigenetic mechanisms on assessed cancer cell lines.In a line with very low (TMK-1), promoter was methylated treatment demethylating agent 5-aza-2'-deoxycytidine restored expression....
Both hydrocortisone and pasireotide have been shown in randomized clinical trials to be effective reducing postoperative complications of pancreatic surgery, but date no trial has evaluated the effectiveness compared with hydrocortisone.To assess noninferiority after partial pancreatectomy.A noninferiority, parallel-group, individually was conducted at a single academic center between May 19, 2016, December 17, 2018. Outcome collectors analyzers were blinded. A total 281 patients undergoing...
Abstract Background Gastric adenocarcinoma is associated with H. pylori infection and inflammation that can result in the dysbiosis of gastric microbiota. The association intestinal microbiota subtypes or gastrointestinal stromal tumors (GIST) however not well known. Therefore, we performed 16S rRNA gene sequencing on DNA isolated from stool samples Finnish patients controls to study differences among different histological adenocarcinoma, GIST healthy controls. Results We found gut alpha...
Abstract Background Recently, the first randomized trials comparing minimally invasive distal pancreatectomy (MIDP) with open (ODP) for non-malignant and malignant disease showed a 2-day reduction in time to functional recovery after MIDP. However, pancreatic ductal adenocarcinoma (PDAC), concerns have been raised regarding oncologic safety (i.e., radical resection, lymph node retrieval, survival) of MIDP, as compared ODP. Therefore, controlled trial MIDP ODP PDAC oncological is warranted....
The desirable lymph node count was determined to maximize the survival time expectancy according among patients who have undergone oesophagectomy for oesophageal cancer.
<h2>Structured abstract</h2><h3>Introduction</h3> International studies on preoperative risk factors of postoperative complications after gastrectomy for gastric cancer are few, and done in a population-based setting or using standardized definitions lacking. Gastrectomy is characterized by high complication rates mortality, identifying the mortality enables to improve outcomes. <h3>Materials methods</h3> This nationwide cohort study based Finnish National Esophago-Gastric Cancer Cohort, it...
Abstract Background Knowledge on the incidence of surgical complications after oesophagectomy for oesophageal cancer in nationwide practice is scarce. The aim this study was to assess complication trends a nationwide, population-based, unselected cohort. Methods All patients undergoing Finland 1987–2016 were included. defined by Esophagectomy Complications Consensus Group (ECCG) reported three 10-year periods. Chi-square test and Kruskal-Wallis used compare outcomes these Results A total...
Abstract Background The use of epidural analgesia has been proposed to improve the prognosis esophageal cancer by attenuating stress response and being less immunosuppressive than opioids. This study aims evaluate association, if any, between non‐epidural pain management compared during minimally invasive or open esophagectomy prognosis. Materials Methods was a population‐based nationwide retrospective cohort in Finland, using Finnish National Esophago‐Gastric Cancer Cohort (FINEGO)....
Background: Indeterminate biliary strictures, that is, a stricture with benign brush cytology but without clear etiology in clinical or radiological assessment, pose challenge for clinicians. This study aimed to assess the incidence and risk factors malignant disease patients indeterminate strictures. Methods: is single-center retrospective of undergoing first endoscopic retrograde cholangiopancreatography (ERCP) brushing between March 2011 2020. The included atypical ERCP samples. Main...