A5026217581- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Gastroesophageal reflux and treatments
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Metastasis and carcinoma case studies
- Pleural and Pulmonary Diseases
- Research in Social Sciences
- Gastrointestinal Tumor Research and Treatment
- Dysphagia Assessment and Management
- Eosinophilic Esophagitis
- Trauma Management and Diagnosis
- Myasthenia Gravis and Thymoma
- Cardiac, Anesthesia and Surgical Outcomes
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Venous Thromboembolism Diagnosis and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ferroptosis and cancer prognosis
- Angiogenesis and VEGF in Cancer
Central Finland Health Care District
2016-2025
Oulu University Hospital
2023
University of Oulu
2023
University of Jyväskylä
2020
Helsinki University Hospital
2007-2016
University of Helsinki
2002-2016
Tampere University Hospital
2006
South Karelia Central Hospital
2006
Tampere University
2006
Biocenter Finland
2002
Abstract Background This population-based study aimed to examine the incidence, patterns and results of multimodal management metastatic colorectal cancer. Methods A retrospective was conducted on patients with cancer in Central Finland 2000–2015. Clinical histopathological data were retrieved descriptive analysis determine pattern disease, defined as synchronous, early metachronous (within 12 months diagnosis primary disease) late (more than after diagnosis). Subgroups compared for...
PURPOSE: Barrett’s esophagus (BE), a precancerous condition for adenocarcinoma, is classically characterized by flames of salmon-colored mucosa extending into normal pale esophageal mucosa. This flaming thought to be consequence continuous erosis caused chronic reflux. Another characteristic feature adenocarcinoma patients the frequent development lymph node metastases. We addressed whether onset angiogenesis occurs in BE and if lymphatic system might provide route cells infiltrate regular...
The desirable lymph node count was determined to maximize the survival time expectancy according among patients who have undergone oesophagectomy for oesophageal cancer.
<h2>Structured abstract</h2><h3>Introduction</h3> International studies on preoperative risk factors of postoperative complications after gastrectomy for gastric cancer are few, and done in a population-based setting or using standardized definitions lacking. Gastrectomy is characterized by high complication rates mortality, identifying the mortality enables to improve outcomes. <h3>Materials methods</h3> This nationwide cohort study based Finnish National Esophago-Gastric Cancer Cohort, it...
Abstract Background Knowledge on the incidence of surgical complications after oesophagectomy for oesophageal cancer in nationwide practice is scarce. The aim this study was to assess complication trends a nationwide, population-based, unselected cohort. Methods All patients undergoing Finland 1987–2016 were included. defined by Esophagectomy Complications Consensus Group (ECCG) reported three 10-year periods. Chi-square test and Kruskal-Wallis used compare outcomes these Results A total...
Abstract Background The use of epidural analgesia has been proposed to improve the prognosis esophageal cancer by attenuating stress response and being less immunosuppressive than opioids. This study aims evaluate association, if any, between non‐epidural pain management compared during minimally invasive or open esophagectomy prognosis. Materials Methods was a population‐based nationwide retrospective cohort in Finland, using Finnish National Esophago‐Gastric Cancer Cohort (FINEGO)....
Abstract Mechanisms underlying the development of oesophageal adenocarcinoma are poorly understood. To discover role oxidative stress and radical scavenger capacity in malignant transformation Barrett's oesophagus, we measured myeloperoxidase activity, superoxide dismutase glutathione content total aromatic DNA adducts. Mucosal specimens came from 52 patients 6 groups: symptomatic gastro‐oesophageal reflux disease (GORD) without with endoscopic oesophagitis, epithelium dysplasia, oesophagus...
Background. Patients undergoing surgery for non-small cell lung cancer (NSCLC) are often elderly with co-morbid conditions and decreased performance status. Thus, the morbidity of resection via thoracotomy may be unacceptable some patients. This is reason why video-assisted thoracoscopic (VATS) instead open has gained more use acceptance, especially in patients stage I disease. The aim this study was to evaluate difference between VATS treatment outcomes NSCLC Methods. A total 328 underwent...
Conclusions: This study demonstrates proof of concept for controlled manufacturing methods that utilize novel tailored biopolymers (3D photocuring technology) or conventional bioresorbable polymers (fused deposition modeling, FDM) macroscopic and microscopic geometry control. The manufactured scaffolds could be suitable tissue engineering research. Objectives: To design trachea scaffold prototypes purposes, to fabricate them by additive manufacturing. Methods: A commercial 3D model CT scans...
Background: Performing minimally invasive surgery requires training and visual-spatial intelligence. The aim of our study was to examine the impact perception additional mental on simulated laparoscopic knot-tying task performed by surgical novices. Methods: A total 40 medical students randomly assigned two groups underwent sessions basic a VR simulator (SimSurgery®, Oslo, Norway). variables time tip trajectory (total path length instrument trajectory) were used assess performance...
Tertiary lymphoid structures (TLSs) are ectopic aggregates located at sites of chronic inflammation and recognized as prognosticators in several cancers. We aimed to analyse the prognostic effect TLSs colorectal cancer (CRC) pulmonary metastases primary tumours, with a comparison CD3+ CD8+ cell density-based immune score (ICS). For TLS density maximum diameter analysis, 67 63 tumours were stained haematoxylin eosin. ICS scoring CD3 CD8 immunohistochemistry was performed. Excellent...
Introduction Surgery for oesophageal and gastric cancers is associated with high morbidity, mortality poor quality of life postoperatively. The Finnish National Esophago-Gastric Cancer Cohort has been established the aim identifying factors that could contribute to improved outcomes in oesophago-gastric cancer. Methods analysis All patients cancer diagnosed Finland between 1987 2015 will be identified from national registries. Registry Patient used identify fulfil inclusion criteria study:...
This retrospective population-based study examined the impact of age and comorbidity burden on multimodal management survival from colorectal cancer (CRC). From 2000 to 2015, 1479 consecutive patients, who underwent surgical resection for CRC, were reviewed age-adjusted Charlson index (ACCI) including 19 well-defined weighted comorbidities. The ACCI was compared between low (score 0–2), intermediate 3) high ≥ 4) groups. Changes in treatment 2015 seen next a major increase laparoscopic...
Background. [18F]fluorodeoxyglycose-Positron Emission Tomography/Computer Tomography ([18F]FDG-PET/CT) is commonly used in staging of locally advanced esophageal cancer. Its predictive value for response to neoadjuvant therapy and survival after multimodality controversial. Methods. Sixty-six consecutive patients with adenocarcinoma the esophagus or esophagogastric junction underwent surgery chemotherapy. Staging was done prospectively [18F]FDG-PET/CT, before completion therapy. Pre-...
Background and aims Thoracotomies can cause severe pain, which persists in 21-67% of patients. We investigated whether NSAID + intravenous patient-controlled analgesia (IV-PCA) with morphine is an efficacious alternative to thoracic epidural (TEA). also wanted find out extended controlled pain management protocol within a clinical study decrease the incidence persistent post-thoracotomy pain. Methods Thirty thoracotomy patients were randomized into 3 intervention groups 10 each. G1:...