A5044725417- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Hernia repair and management
- Pancreatic and Hepatic Oncology Research
- Immune Cell Function and Interaction
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Colorectal Cancer Treatments and Studies
- Intestinal and Peritoneal Adhesions
- Colorectal Cancer Surgical Treatments
- Amyotrophic Lateral Sclerosis Research
- Appendicitis Diagnosis and Management
- Colorectal and Anal Carcinomas
- Intraperitoneal and Appendiceal Malignancies
- Cardiac, Anesthesia and Surgical Outcomes
- Anorectal Disease Treatments and Outcomes
- Lung Cancer Diagnosis and Treatment
- Pelvic floor disorders treatments
- Pelvic and Acetabular Injuries
- Helicobacter pylori-related gastroenterology studies
Turku University Hospital
2022-2025
Kuopio University Hospital
2025
University of Helsinki
2024
Helsinki University Hospital
2024
Central Finland Health Care District
2020-2022
Tampere University
2020
Tampere University Hospital
2020
University of Eastern Finland
2016
<h2>Structured abstract</h2><h3>Introduction</h3> International studies on preoperative risk factors of postoperative complications after gastrectomy for gastric cancer are few, and done in a population-based setting or using standardized definitions lacking. Gastrectomy is characterized by high complication rates mortality, identifying the mortality enables to improve outcomes. <h3>Materials methods</h3> This nationwide cohort study based Finnish National Esophago-Gastric Cancer Cohort, it...
TDP-43 is the main protein component of ubiquitinated inclusions in a subgroup frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS) patients. The C9ORF72 hexanucleotide expansion one mutations associated with pathology FTLD ALS. Our aim was to analyze cerebrospinal fluid (CSF) levels Alzheimer's disease biomarkers ALS patients test whether carrier status affects these variables.The patient cohort consisted 90 clinically well-characterized (n = 69) 21) There were...
Tertiary lymphoid structures (TLSs) are part of immune response against cancer. Their high density and diameter have been shown to be associated with prognosis in different cancer types. The aim this study was examine the prognostic significance TLS gastric reproducibility their assessments. densities maximal were assessed from hematoxylin-eosin (HE) stained slides 721 surgically treated patients two hospitals Finland. Mortality hazard ratios (HRs) for analyzed. moderate interobserver...
There is a lack of evidence regarding anastomotic technique and postoperative complications in gastric cancer surgery. The aim the study was to evaluate whether there are differences between stapled hand-sewn anastomosis leaks. This population based, retrospective, nationwide cohort Finland using Finnish National Esophago-Gastric Cancer Cohort (FINEGO). Gastrectomy patients with available complication data were included. Logistic regression analysis used calculate odds ratios (OR) 95%...
Abstract Background Immune response against cancer has prognostic impact but its role in gastric is poorly known. The aim of the study was to assess significance immune cell score (CD3+, CD8+), tumour escape (PD-L1, PD-1) and tolerance (Clever-1). Methods After exclusion Epstein-Barr virus positive ( n = 4) microsatellite instable 6) tumours, included 122 patients with GC undergoing D2 gastrectomy. CD3+ CD8+ based ICS, PD-L1, PD-1 Clever-1 expressions were evaluated. Differences survival...
The aim of study was to compare overall 5-year survival esophageal cancer patients undergoing transthoracic esophagectomy with either neck or intrathoracic anastomosis, that is, McKeown and Ivor-Lewis esophagectomy.No national studies comparing long-term after ivor-Lewis esophagectomies in the West exist.This population-based nationwide included all curatively intended for adenocarcinoma squamous cell carcinoma Finland 1987 2016, follow-up until December 31, 2019. Cox proportional hazard...
Abstract Background To date, no large population-based studies have compared complications and short-term outcomes between neoadjuvant chemotherapy upfront surgery in gastric cancer. More nationwide with standardized reporting on are needed to enable international comparison studies. This study aimed compare postoperative therapy after gastrectomy for adenocarcinoma a setting. Methods based the Finnish National Esophago-Gastric Cancer Cohort included all patients 18 years of age or older...
Purpose: To examine and compare the prognostic value of immune cell score (ICS) Klintrup–Mäkinen (KM) grade in gastric cancer. Methods: Gastric adenocarcinoma tissues from samples 741 patients surgically treated two hospitals Finland were assessed for ICS KM grade. Cox regression with adjustment confounders provided hazard ratios (HRs) 95% CIs. Subgroup analyses performed intestinal diffuse type subgroups. The primary outcome was 5-year overall survival. Results: High associated to longer...
Abstract Background The purpose of this study was to examine the rates 90-day anastomotic complications and other postoperative after total or partial gastrectomy with antecolic versus retrocolic reconstruction in a population-based setting. Methods This nationwide retrospective cohort included all patients undergoing for gastric adenocarcinoma Finland 2005–2016, follow-up until 31 December 2019. Logistic regression provided odds ratios (ORs) 95% confidence intervals (CIs) mortality. Results...
No national studies comparing long-term survival after total or partial gastrectomy with splenectomy due to injury oncologic reasons spleen preservation exist. This study aimed examine the 5-year overall (OS) of patients gastric adenocarcinoma who underwent in a population-based nationwide setting.
Abstract Background No population-based studies comparing long-term survival after transhiatal esophagectomy (THE) and transthoracic (TTE) exist. This study aimed to compare the 5-year of esophageal cancer patients undergoing THE or TTE in a nationwide setting. Methods included all curatively intended for Finland during 1987–2016, with follow-up evaluation until 31 December 2019. Cox proportional hazard models provided ratios (HRs) 95% confidence intervals (CIs) 90-day mortality. The results...
Multimodal treatment of gastric cancer includes careful preoperative staging, perioperative oncological treatment, and selective minimally invasive approach. The aim was to evaluate whether this approach improves short- long-term outcomes in operable cancer. This study included 181 patients who underwent curative intent surgery Central Finland Hospital between years 2005 2021 for or esophagogastric junction adenocarcinoma. Those 65 group 1 operated 2005–2010 had open with possible adjuvant...
Abstract Background Minimally invasive ventral mesh rectopexy (VMR) is a widely used surgical treatment for posterior pelvic organ prolapse; however, evidence of the utility revisional surgery lacking. Our aim was to assess technical details, safety and outcomes redo minimally VMR patients with external rectal prolapse (ERP) recurrence or relapsed symptoms internal (IRP). Methods This retrospective cohort study recurrent ERP symptomatic IRP who underwent between 2011 2016. The conducted at...
This study aimed to examine the rate of delayed emptying and other 90-day postoperative complications after total, subtotal, distal gastrectomies for gastric adenocarcinoma in a population-based setting.
Amyand’s hernia is a rare entity where the appendix trapped within inguinal canal. For even rarer are cases has perforated and caused an abscess into Here we report case male patient had hernia, acute appendicitis which were treated by laparotomy. We present diagnostic process intraoperative finding leading to diagnosis of hernia.
Esophageal cancer (EC) is the ninth most common worldwide and sixth leading cause of death [1]. Despite improvements in treatment EC, general outcome remains poor [2–4]...