Alessandro Vanoli
A5021643347- Neuroendocrine Tumor Research Advances
- Pancreatic and Hepatic Oncology Research
- Celiac Disease Research and Management
- Gastrointestinal disorders and treatments
- Eosinophilic Esophagitis
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Gastrointestinal Tumor Research and Treatment
- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Microscopic Colitis
- Neuroblastoma Research and Treatments
- Inflammatory Bowel Disease
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Metastasis and carcinoma case studies
- Galectins and Cancer Biology
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Pancreatitis Pathology and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Cancer Genomics and Diagnostics
- Pituitary Gland Disorders and Treatments
- Immunodeficiency and Autoimmune Disorders
University of Pavia
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Policlinico San Matteo Fondazione
2011-2025
University Hospital Foundation
2019-2024
Azienda Ospedaliera di Padova
2024
University of Verona
2023
University of Insubria
2014-2017
Hôpital Sainte-Périne
2014-2015
Université de Poitiers
2012
Musée de la Civilisation
2012
<h3>Objective</h3> External fistulas represent a disabling manifestation of Crohn9s disease with difficult curability and high relapse rate despite large therapeutic armamentarium. Stem cell therapy is novel promising approach for treatment chronic inflammatory conditions. We therefore investigated the feasibility, safety efficacy serial intrafistular injections autologous bone marrow-derived mesenchymal stromal cells (MSCs) in fistulising disease. <h3>Patients methods</h3> enrolled 12...
Gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) are defined as neoplasms (NENs) with a Ki-67 index >20% according to the 2010 WHO classification. Some reports suggest that this category is heterogeneous. We retrospectively studied series of 136 patients affected by grade 3 GEP-NECs aim clarify prognostic role tumor morphological differentiation, proliferation, defect in mismatch repair proteins (MMRd), CD117 expression, and site origin. The primary endpoint was correlation...
The oncological safety of minimally invasive surgery has been questioned for several abdominal cancers. Concerns also exist regarding the use distal pancreatectomy (MIDP) in patients with resectable pancreatic cancer as randomised trials are lacking.In this international non-inferiority trial, we recruited adults from 35 centres 12 countries. Patients were randomly assigned to either MIDP (laparoscopic or robotic) open (ODP). Both and pathologists blinded approach. Primary endpoint was...
Acinar cell carcinoma (ACC) of the pancreas is a very rare tumor that has various morphologic features, which may give rise to diagnostic difficulties. Because its rarity, many clinicopathologic characteristics remain be further elucidated, and prognostic factors are yet well established. With aim better characterizing this searching for indicators, we collected 62 ACCs investigated following parameters: site, size, local infiltration, node distant metastases, architectural pattern, nuclear...
Gastroenteropancreatic (GEP) neuroendocrine carcinomas (NECs) and mixed adenoneuroendocrine (MANECs) are heterogeneous neoplasms characterized by poor outcome. Microsatellite instability (MSI) has recently been found in colorectal NECs showing a better prognosis than expected. However, the frequency of MSI large series GEP-NEC/MANECs is still unknown. In this work, we investigated incidence their clinicopathologic molecular features. analysis immunohistochemistry for mismatch repair proteins...
Background: Several types of neuroendocrine neoplasms (NENs) have been described in the duodenal tract, from low-grade tumors (NETs) to high-grade carcinomas (NECs). A comprehensive analysis histology, hormonal profile and prognostic parameters a sufficiently large NEN series cover all main kinds is however lacking. Methods: We collected retrospective 203 wall ampullary region NENs, six specialized endocrine pathology centers. All were characterized histopathologically histochemically, 190...
Background: The World Health Organization (WHO) and the American Joint Cancer Committee (AJCC) modified grading of pancreatic neuroendocrine neoplasms from a three-tier (WHO-AJCC 2010) to four-tier system by introducing novel category NET G3 2017). Objectives: This study aims at validating WHO-AJCC 2017 identifying most effective system. Method: A total 2,102 patients were enrolled; entry criteria were: (i) patient underwent surgery; (ii) least 2 years follow-up; (iii) observation time up...
Mixed adenoneuroendocrine carcinomas (MANECs) are composed of a poorly differentiated neuroendocrine carcinoma (NEC) and non-neuroendocrine (non-NEC) neoplastic epithelial component, each representing at least 30% the tumor. At present, prognostic factors for MANECs remain largely unexplored. We investigated clinical-pathologic features large multicenter series digestive system MANECs. Surgical specimens 200 MANEC candidates were centrally reviewed; diagnosis was confirmed in 160 cases....
Summary Background Autoimmune atrophic gastritis (AAG) is characterised by a wide clinical spectrum that could delay its diagnosis. Aims To quantify the diagnostic in patients suffering from AAG and to explore possible risk factors for longer delay. Methods Consecutive with evaluated at our gastroenterological outpatient clinic between 2009 2018 were included. Diagnostic was estimated as time lapse occurring appearance of first likely symptoms, laboratory alterations, other clues indicative...
Summary Background Autoimmune atrophic gastritis (AAG) is an immune‐mediated disorder characterised by destruction of gastric oxyntic mucosa Aim To explore histopathological evolution in a cohort AAG patients over prolonged follow‐up Methods Single centre prospective study enrolling consecutive with histologically confirmed between 2000 and 2018. All undergoing endoscopic every 1‐3 years were classified as having stages 1, 2 or 3 according to atrophy severity (mild, moderate severe). either...
<b><i>Background:</i></b> Gastric neuroendocrine neoplasms (NENs) are very heterogeneous, ranging from mostly indolent, atrophic gastritis-associated, type I tumors (NETs), through highly malignant, poorly differentiated carcinomas (pdNECs), to sporadic III NETs with intermediate prognosis, and various rare tumor types. Histologic differentiation, proliferative grade, size, level of gastric wall invasion, local or distant metastases used as prognostic markers....
An increased risk of small bowel carcinoma [SBC] has been reported in coeliac disease [CD] and Crohn's [CrD]. We explored clinico-pathological, molecular, prognostic features CD-associated SBC [CD-SBC] CrD-associated [CrD-SBC] comparison with sporadic [spo-SBC].A total 76 patients undergoing surgical resection for non-familial [26 CD-SBC, 25 CrD-SBC, spo-SBC] were retrospectively enrolled to investigate patients' survival histological molecular including microsatellite instability [MSI]...