A5040724230- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Neuroendocrine Tumor Research Advances
- Pancreatic function and diabetes
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
- Multiple and Secondary Primary Cancers
- Cardiac, Anesthesia and Surgical Outcomes
- Diabetes and associated disorders
- Renal cell carcinoma treatment
- Cancer Diagnosis and Treatment
- Diabetes Management and Research
- Enhanced Recovery After Surgery
- Esophageal and GI Pathology
- Neuroblastoma Research and Treatments
- Surgical site infection prevention
- Abdominal vascular conditions and treatments
- Cancer Cells and Metastasis
- Renal Transplantation Outcomes and Treatments
- Colorectal Cancer Treatments and Studies
IRCCS Humanitas Research Hospital
2015-2024
Humanitas University
2014-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2012-2023
Morriston Hospital
2017
University of Milan
1991-2014
Fondazione Humanitas per la Ricerca
1990-2014
San Raffaele University of Rome
1991-2009
Pancreas Centre (Canada)
2008
Vita-Salute San Raffaele University
2004-2005
Objective: The aim of this study was to compare oncological outcomes after minimally invasive distal pancreatectomy (MIDP) with open (ODP) in patients pancreatic ductal adenocarcinoma (PDAC). Background: Cohort studies have suggested superior short-term MIDP vs. ODP. Recent international surveys, however, revealed that surgeons concerns about the for PDAC. Methods: This is a pan-European propensity score matched including who underwent (laparoscopic or robot-assisted) ODP PDAC between...
Tumour-associated macrophages (TAMs) play key roles in tumour progression. Recent evidence suggests that TAMs critically modulate the efficacy of anticancer therapies, raising prospect their targeting human cancer.In a large retrospective cohort study involving 110 patients with pancreatic ductal adenocarcinoma (PDAC), we assessed density CD68-TAM immune reactive area (%IRA) at tumour-stroma interface and addressed prognostic relevance relation to postsurgical adjuvant chemotherapy (CTX). In...
B-cell responses are emerging as critical regulators of cancer progression. In this study, we investigated the role B lymphocytes in microenvironment human pancreatic ductal adenocarcinoma (PDAC), a retrospective consecutive series 104 PDAC patients and preclinical models. Immunohistochemical analysis revealed that cells occupy two histologically distinct compartments PDAC, either scatteringly infiltrating (CD20-TILs), or organized tertiary lymphoid tissue (CD20-TLT). Only when retained...
The routine use of preoperative biliary drainage before pancreaticoduodenectomy (PD) remains controversial. This observational retrospective study compared stented and non-stented patients undergoing PD to assess any differences in post-operative morbidity mortality. A total 180 consecutive who underwent had intra-operative bile cultures performed between January 2010 February 2013 were retrospectively identified. All received peri-operative intravenous antibiotic prophylaxis, primarily...
Background: The World Health Organization (WHO) and the American Joint Cancer Committee (AJCC) modified grading of pancreatic neuroendocrine neoplasms from a three-tier (WHO-AJCC 2010) to four-tier system by introducing novel category NET G3 2017). Objectives: This study aims at validating WHO-AJCC 2017 identifying most effective system. Method: A total 2,102 patients were enrolled; entry criteria were: (i) patient underwent surgery; (ii) least 2 years follow-up; (iii) observation time up...
Abstract Pancreatic carcinoma is a very aggressive disease with dismal prognosis. Although evidences for tumor-specific T cell immunity exist, factors related to tumor microenvironment and the presence of immunosuppressive cytokines in patients’ sera have been its behavior. Carcinoembryonic Ag (CEA) overexpressed 80–90% pancreatic carcinomas contains epitopes recognized by CD4+ cells. The aim this study was evaluate extent cancer-immune surveillance immune suppression patients comparing...
Abstract Background Duodenal adenocarcinoma (DA) is a rare yet aggressive malignancy, with increasing incidence in the last decades. Its low frequency has hampered thorough understanding of pathogenesis disease and its biology, limiting identification tailored therapeutic options. A large body evidence clearly shown clinical relevance immune cells solid tumors, correlating features post-surgical prognosis. The aim this study was to analyze contexture cohort duodenal adenocarcinomas...
In Brief Objectives: Development of a simple preoperative risk score to predict morbidity related pancreatic surgery. Background: Pancreatic surgery is standardized with little technical diversity among institutions and unchanging mortality rates in recent years. Preoperative identification high-risk patients potentially one the rare avenues for improving clinical course undergoing Methods: Using prospectively collected multicenter database (n = 703), surgical complications were classified...
Islet autotransplantation (IAT) is usually performed in patients undergoing pancreatic surgery for chronic pancreatitis. In the present series, IAT was offered also to both nonmalignant and malignant diseases, having either completion pancreatectomy as treatment severe fistulas (n = 21) or extensive distal neoplasms of neck 19) pancreatoduodenectomy because high risk fistula 32). Fifty-eight 72 who were eligible this broader spectrum indication actually received IAT. There no evidence a...
To compare pancreaticoduodenectomy (PD) and total pancreatectomy (TP) with islet autotransplantation (IAT) in patients at high risk of postoperative pancreatic fistula (POPF).
Pancreatogenic diabetes, a consequence of pancreatic tissue loss following pancreatectomy, poses significant challenge for patients undergoing surgery. Islet autotransplantation (IAT) offers promising approach to prevent or alleviate pancreatogenic but its application has been limited individuals with painful chronic pancreatitis.
In Brief Objective: To optimize the results of low-volume (LV) centers for hepatopancreaticobiliary (HPB) surgery. Background: High-volume (HV) HPB surgery have lower mortality than LV. Strategies collaboration between HV and LV are not well investigated. Methods: Postoperative outcomes patients undergoing curative resection were evaluated at an hospital before (2006–2008) during (2009–2012) 2 hospitals with either liver or pancreatic (2009–2012). Itinerant tutor surgeons from involved in...
Objective: To analyze possible associations between the duration of stent placement before surgery and occurrence severity postoperative complications after pancreatoduodenectomy (PD). Background: The effect preoperative on outcomes PD has not been investigated. Methods: From 2013 to 2016, patients who underwent for any reasons biliary at 5 European academic centers were analyzed from prospectively maintained databases. primary aim was investigate association stenting morbidity. Patients...
Many tumors may secondarily involve the pancreas; however, only retrospective autopic and surgical series are available. We retrospectively collected data from all consecutive patients with histologically confirmed secondary of pancreas referred to five Italian centers between 2010 2021. described clinical pathological features, therapeutic approach treatment outcomes. EUS characteristics lesions tissue acquisition procedures (needle, passages, histology) were recorded. A total 116...
Pancreatic surgery is challenging and associated with high morbidity, mainly represented by postoperative pancreatic fistula (POPF) its further consequences. Identification of risk factors for POPF essential proper management.Evaluation the role morphological histological features stump, other than main duct diameter glandular texture, in occurrence after pancreaticoduodenectomy.Between March 2011 April 2013, we performed 145 consecutive pancreaticoduodenectomies. We intraoperatively...
Better understanding of pancreatic diseases, including ductal adenocarcinoma (PDAC), is an urgent medical need, with little advances in preoperative differential diagnosis, preventing rational selection therapeutic strategies. The clinical management cancer patients would benefit from the identification variables distinctively associated multiplicity disorders. We investigated, by 1H nuclear magnetic resonance, metabolomic fingerprint juice (the biofluid that collects products) 40 different...
Pancreatic cancer is a very aggressive disease with dismal prognosis; peculiar the tumor microenvironment characterized by an extensive fibrotic stroma, which favors rapid progression. We previously reported that pancreatic patients have selective Th2 skew in anti-carcinoembryonic antigen (CEA) CD4(+) T cell immunity, correlates presence of predominant GATA-3(+) lymphoid infiltrate. This has negative effects both effective anti-tumor immunity and further favoring fibrinogenesis. Aim this...
Surgical site infections (SSIs) are extremely common in pancreatic surgery and explain its considerable morbidity mortality, even tertiary centers. Early detection of these complications, with the help laboratory assays, improve clinical outcome. The aim present study is to evaluate C-reactive protein (CRP) diagnostic accuracy as early predictor SSIs after pancreaticoduodenectomy (PD).We considered 251 consecutive PD. We prospectively recorded preoperative anthropometric data, intraoperative...