A5008060437- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Gallbladder and Bile Duct Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Screening and Detection
- Liver Disease and Transplantation
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Diverticular Disease and Complications
- Neuroendocrine Tumor Research Advances
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Genetic factors in colorectal cancer
- Inflammatory Bowel Disease
- Organ Transplantation Techniques and Outcomes
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Metastasis and carcinoma case studies
- Lymphatic System and Diseases
- Renal cell carcinoma treatment
Humanitas University
2016-2025
IRCCS Humanitas Research Hospital
2016-2025
University of Amsterdam
2024
Amsterdam University Medical Centers
2024
King Faisal Specialist Hospital & Research Centre
2023
Istituti di Ricovero e Cura a Carattere Scientifico
2008-2021
Società Italiana di Cardiologia
2021
Ministero della Salute
2021
Royal Free London NHS Foundation Trust
2021
University of Rome Tor Vergata
2018
Abstract Hepatocellular nodules in cirrhosis include regenerative (large regenerative, LRN) and dysplastic (low high grade, LGDN HGDN) nodules, early grade 1 HCC (eHCC-G1), overt HCC. The differential diagnosis may be particularly difficult when lesions such as HGDN eHCC-G1 are involved. We investigated the diagnostic yield of a panel 3 putative markers hepatocellular malignancy HSP70, glypican (GPC3), glutamine synthetase (GS). selected 52 surgically removed nonmalignant (15 LRNs, 15 LGDNs,...
Objective: The aim of this study was to compare oncological outcomes after minimally invasive distal pancreatectomy (MIDP) with open (ODP) in patients pancreatic ductal adenocarcinoma (PDAC). Background: Cohort studies have suggested superior short-term MIDP vs. ODP. Recent international surveys, however, revealed that surgeons concerns about the for PDAC. Methods: This is a pan-European propensity score matched including who underwent (laparoscopic or robot-assisted) ODP PDAC between...
The outcome of patients with colorectal cancer is more favorable when the tumor exhibits high-frequency microsatellite instability (MSI). Although associated earlier-stage tumors, MSI has been proposed as an independent predictor survival. We tested prognostic value in a large series diagnosed last decade.The survival 893 consecutive characterized by status was analyzed. 89 (10%) were classified according to mismatch repair (MMR) defect, MMR germ-line mutation, hMLH1 and p16 promoter...
Studies comparing magnetic resonance enterography (MRE) and computerized tomography (CTE) for Crohn's disease (CD) are scarce. The aim of this study was to prospectively compare the sensitivity, specificity, accuracy abdominal MRE CTE assess activity complications (fistulas, strictures) in ileocolonic CD. A total 44 patients (23 male; 21 female; mean age 44) with CD underwent both MR CT a short time interval (mean 5 days). 16-slice intravenous contrast an MRI oral paramagnetic were...
Similarly to other tumor types, an imbalance between unrestrained cell proliferation and impaired apoptosis appears be a major unfavorable feature of hepatocellular carcinoma (HCC). The members IAP family are key regulators apoptosis, cytokinesis signal transduction. survival action is antagonized by specific binding Smac/DIABLO XAF1. This study aimed investigate the gene protein expression pattern their antagonists in series human HCCs assess clinical significance.Relative quantification...
To evaluate the role of an absorbable fibrin sealant patch (TachoSil) in reducing postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP).POPF remains main complication DP.This was a prospective, open, randomized, study which patients undergoing elective DP were randomized to standard surgical suturing or stapling with without TachoSil. The primary end point incidence POPF according International Study Group on Pancreatic Fistula criteria. Amylase level drainage fluid,...
Objective: The ISGPS aimed to develop a universally accepted definition for PPAP standardized reporting and outcome comparison. Background: : is an increasingly recognized complication after partial pancreatic resections, but its incidence clinical impact, even existence are variable because internationally consensus grading system lacking. Methods: developed of with members evidence review series discussions multiple revisions from April 2020 May 2021. Results: We defined as acute...
The routine use of preoperative biliary drainage before pancreaticoduodenectomy (PD) remains controversial. This observational retrospective study compared stented and non-stented patients undergoing PD to assess any differences in post-operative morbidity mortality. A total 180 consecutive who underwent had intra-operative bile cultures performed between January 2010 February 2013 were retrospectively identified. All received peri-operative intravenous antibiotic prophylaxis, primarily...
Background: Robotic surgery is increasingly used to resect lung cancer. However costs are high. We compared and outcomes for robotic surgery, video-assisted thoracic (VATS), open treat non-small cell cancer (NSCLC). Methods: retrospectively assessed 103 consecutive patients given lobectomy or segmentectomy clinical stage I II NSCLC. Three surgeons could choose VATS open, the fourth between all three techniques. Between-group differences were by Fisher's exact, two-way analysis of variance...
Abstract Aim The use of robotic techniques in colorectal surgery is increasing. Recently, the Senhance™ surgical system was introduced as a novel platform designed to overcome some limits standard laparoscopy. This study describes initial, single‐center experience, evaluating feasibility and safety new performing procedures. Methods From June 2015 November 2016, perioperative data first 45 patients who underwent with were collected analysed. Indications for included inflammatory bowel...
BackgroundThere is little evidence about the prevalence of cognitive disorders and their effect on in-hospital mortality in large multicenter studies. The objectives 2016th edition “Italian Delirium Day,” a study older patients, were to assess (i) point impairment/no dementia, delirium, delirium superimposed dementia (ii) these conditions mortality.