A5060064110- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Surgical Treatments
- Gallbladder and Bile Duct Disorders
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Genomics and Diagnostics
- Esophageal and GI Pathology
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Cardiac Valve Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiac and Coronary Surgery Techniques
- Colorectal Cancer Screening and Detection
- Pediatric Hepatobiliary Diseases and Treatments
- Nanoparticle-Based Drug Delivery
- Genetic factors in colorectal cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer Research and Treatments
- Advanced biosensing and bioanalysis techniques
- Cancer Treatment and Pharmacology
- Gastrointestinal Tumor Research and Treatment
Campus Bio Medico University Hospital
2005-2025
Università Campus Bio-Medico
2015-2024
Italian Association for Cancer Research
2024
Flinders University
2024
Flinders Medical Centre
2024
University of Verona
2024
University of Siena
2022
Sapienza University of Rome
2005-2021
Università degli Studi di Enna Kore
2015-2021
University of Pisa
2021
To evaluate the role of an absorbable fibrin sealant patch (TachoSil) in reducing postoperative pancreatic fistula (POPF) after distal pancreatectomy (DP).POPF remains main complication DP.This was a prospective, open, randomized, study which patients undergoing elective DP were randomized to standard surgical suturing or stapling with without TachoSil. The primary end point incidence POPF according International Study Group on Pancreatic Fistula criteria. Amylase level drainage fluid,...
Pancreatic cancer is a very aggressive malignancy that often diagnosed in the advanced stages, with implication long-term survivors are extremely rare. Thus, developing new methods for early detection of pancreatic an urgent task current research. To date, nanotechnology offers unprecedented opportunities therapeutics and diagnosis. The aim this study development diagnostic technology based on exploitation nano-bio-interactions between nanoparticles blood samples. In study, samples from 20...
The impact of method anastomosis and minimally invasive surgical technique on clinical outcomes after right hemicolectomy is uncertain. aim the MIRCAST study was to compare intracorporeal extracorporeal (ICA ECA respectively), each using either a laparoscopic approach or robot-assisted surgery during hemicolectomies for benign malignant tumours.This an international, multicentre, prospective, observational, monitored, non-randomized, parallel, four-cohort (laparoscopic ECA; ICA; ICA)....
Rectal robotic surgery gained momentum in the last decade, but it is still associated with not-negligible costs. In order to reduce costs, recently different systems have received approval for clinical use. This study aims present first case series of rectal resection novel cost-effective platform Robotic Assisted Surgery (RAS) Hugo™. Tips effective set up system and detailed configuration tilt docking angles are also provided.
The most common adverse event typically associated with bisphosphonate therapy is transient fever. aim of this study was to define the role main cytokines acute-phase reaction interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) involved in pathogenesis zoledronic acid-induced Eighteen consecutive cancer patients bone metastases were treated, for first time, a single dose 4 mg acid infusion. They prospectively evaluated circulating TNF-α, interferon-γ (IFN-γ), IL-6 levels at different...
Defunctioning stoma is a common surgical procedure, but the choice of remains controversial. The preference for colostomy or ileostomy depends on type surgery and surgeon who performs procedure. Stoma reversal often performed few weeks after colorectal resection studies have analysed long-term complications different types stoma. This study aims to determine which associated with lower rate complications.A retrospective patients undergoing from 1998 2004 creation was conducted. Only followed...
The protein corona boosts the cellular uptake of clinically approved PEGylated lipid nanoparticles in pancreas ductal adenocarcinoma cells.
Characterization of the biomolecular corona graphene oxide nanoflakes allows discriminating cancer patients from healthy subjects with high prediction accuracy.
The protein corona (PC) that forms around nanomaterials upon exposure to human biofluids (e.g., serum, plasma, cerebral spinal fluid etc.) is personalized, i.e., it depends on alterations of the proteome as those occurring in several cancer types. This may relevant for early detection when changes concentration typical biomarkers are often too low be detected by blood tests. Among under development
The epidermal growth factor receptor (EGFR), which participates in signalling pathways that are deregulated cancer cells, is frequently mutated colorectal-cancer cells. Cetuximab a monoclonal antibody specifically blocks the EGFR. We evaluated efficacy of cetuximab weekly combination with irinotecan metastatic colorectal patients refractory to previous treatments based on oxaliplatin or irinotecan. included 55 heavily pretreated (colon/rectum: 34/11, M/F: 16/29, median age 63 years, range:...
Abstract Attempts to enhance patients’ immune responses malignancies have been largely unsuccessful. We now describe an immune-escape mechanism mediated by the inhibitory receptor Ig-like transcript 3 (ILT3) that may be responsible for such failures. Using a humanized SCID mouse model, we demonstrate soluble and membrane ILT3 induce CD8+ T suppressor cells prevent rejection of allogeneic tumor transplants. Furthermore, found patients with melanoma, carcinomas colon, rectum, pancreas produce...
hERG1 channels are aberrantly expressed in human cancers. The expression, functional role and clinical significance of pancreatic ductal adenocarcinoma (PDAC) is lacking. expression was tested PDAC primary samples assembled as tissue microarray by immunohistochemistry using an anti-hERG1 monoclonal antibody (α-hERG1-MoAb). studied cell lines cultures. ERG1 during progression Pdx-1-Cre,LSL-KrasG12D/+,LSL-Trp53R175H/+ transgenic (KPC) mice. vivo determined optical imaging Alexa-680-labelled...
Pancreatic ductal adenocarcinoma (PDAC) is the fourth cause of cancer-related mortality in Western world and envisaged to become second by 2030. Although our knowledge about molecular biology PDAC continuously increasing, this progress has not been translated into better patients' outcome. Liposomes have used circumvent concerns associated with low efficiency anticancer drugs such as severe side effects damage healthy tissues, but they resulted improved efficacy yet. Recently, concept...
Pancreatic ductal adenocarcinoma (PDAC) represents an unmet medical need. Difficult/late diagnosis as well the poor efficacy and high toxicity of chemotherapeutic drugs result in dismal prognosis. With aim improving treatment outcome PDAC, we tested effect combining Gemcitabine with a novel single chain bispecific antibody (scDb) targeting cancer-specific hERG1/β1 integrin complex. First, using scDb (scDb-hERG1-β1) immunohistochemistry (IHC), Western blot (WB) analysis immunofluorescence...