A5032847348- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Hernia repair and management
- Appendicitis Diagnosis and Management
- Colorectal and Anal Carcinomas
- Diverticular Disease and Complications
- COVID-19 and healthcare impacts
- Esophageal and GI Pathology
- Minimally Invasive Surgical Techniques
- Pelvic and Acetabular Injuries
- Genetic factors in colorectal cancer
- Gallbladder and Bile Duct Disorders
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Treatments and Studies
- Enhanced Recovery After Surgery
- Stoma care and complications
- Gastrointestinal disorders and treatments
- Surgical Simulation and Training
- Trauma and Emergency Care Studies
- Fatty Acid Research and Health
- Intraperitoneal and Appendiceal Malignancies
- Pediatric Hepatobiliary Diseases and Treatments
- Surgical site infection prevention
Norfolk and Norwich University Hospital
2015-2025
Norfolk and Norwich University Hospitals NHS Foundation Trust
2016-2024
University of East Anglia
2019-2024
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2020-2021
University of Birmingham
2020-2021
Institut de Virologie
2021
NIHR Birmingham Biomedical Research Centre
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
Association for Cancer Surgery
2021
The impact of method anastomosis and minimally invasive surgical technique on clinical outcomes after right hemicolectomy is uncertain. aim the MIRCAST study was to compare intracorporeal extracorporeal (ICA ECA respectively), each using either a laparoscopic approach or robot-assisted surgery during hemicolectomies for benign malignant tumours.This an international, multicentre, prospective, observational, monitored, non-randomized, parallel, four-cohort (laparoscopic ECA; ICA; ICA)....
To determine the outcome of surgery for colorectal cancer from a single region and to see whether location primary influences prognosis.Patients with diagnosed January 2002 December 2006, entered into prospective database were followed until death or 2008. Right-sided (caecum transverse colon) left-sided (splenic flexure rectosigmoid junction) colonic cancers rectal (distal junction anus) identified. Statistical analysis was performed using Pearson's chi-square test, Kaplan-Meier (log-rank...
Abstract Background Acute appendicitis is the most common surgical diagnosis of abdominal pain. Perforated can result in increased morbidity and mortality. Identifying a perforation early reduce impact on patient. Bilirubin, C ‐reactive protein ( CRP ) white cell count WCC have been shown to indicate appendicitis. This study aimed identify whether these biochemical markers be used if patients are suitable for either conservative or approach. Methods A retrospective post hoc analysis all...
Abstract Aim High stoma output and dehydration is common following ileostomy formation. However, the impact of this on renal function, both in short term after reversal, remains poorly defined. We aimed to assess independent kidney function an rectal cancer surgery subsequent reversibility closure. Methods This retrospective single‐site cohort study identified patients undergoing resection from 2003 2017, with or without a diverting ileostomy. Renal was calculated preoperatively, before...
Abstract BACKGROUND Evidence is growing for beneficial interactions between omega‐3 fatty acids from fish and chemotherapy agents in certain human cancers. similar effects prostate cancer lacking. We investigated the of docosahexaenoic acid (DHA‐22:6n‐3), a component oil, on cytotoxicity docetaxel cells. METHODS Cell viability was studied using MTT assay apoptosis evaluated by flow cytometry PI, annexin V, JC‐1 staining. Cellular signaling mechanisms that might explain observed pro‐apoptotic...
To assess the use of topical negative pressure (TNP) in management severe peritonitis.This is a four-year prospective analysis from January 2005 to December 2008 20 patients requiring TNP following laparotomy for peritonitis.There were 11 males with an average age (59.3 +/- 3.95) years. Nine had perforated viscus, five anastomotic leaks, three iatrogenic bowel injury, and further pelvic inflammatory disease. VAC(R) Abdominal Dressing System initially used. These changed every two days....
Reports suggested an increase in enterocutaneous fistulae with topical negative pressure (TNP) use the open abdomen. The purpose of this study was to establish if our experience raises similar concerns.This is a 5-year prospective analysis, from January 2004 December 2008, 42 patients who developed deep wound dehiscence or their abdomen left at laparotomy requiring 'TNP' assist management. decision TNP taken it felt unwise not feasible close abdomen.There were 22 men; median age 68 (range...
R0 resection of locally advanced or recurrent rectal cancer is the key determinant outcome. Disease extension high on sacrum has been considered a contraindication to surgery because associated morbidity and difficulty in achieving complete pathological resection. Total sacrectomy with poor function.We describe novel technique subcortical (HiSS) facilitate disease extending upper at S1 S2 avoid total nonoperative approach management. Details patient demographics, radiology, operative...
Robotic assisted surgery (RAS) has become increasingly adopted in colorectal cancer surgery. This study aims to compare robotic and laparoscopic approaches left sided resections terms of surgical outcomeswith no formal enhanced recovery programme. All patients undergoing or rectal (high low anterior resection) at a single tertiary referral centre over 3 years were included.A total 184 consecutive from July 2017 December 2020 included this study, with 40.2% (n=74/184) RAS. The median age time...
Probiotics are increasingly advocated in the management of various gastrointestinal disorders. The aim this study was to investigate current attitudes and prescribing practices surgeons gastroenterologists for probiotics treatment disorders.A questionnaire designed look at frequency probiotic prescribing, types used, indications duration clinicians' experiences with use. A total 220 questionnaires were mailed consultant practicing UK.The overall response rate 80.5%, which 69.5% respondents...
Gallstone ileus is an uncommon cause of intestinal obstruction and occurs following the formation a cholecystoenteric fistula, permitting passage gallstones into gastrointestinal tract. Impaction gallstone in sigmoid colon rare usually at sites previous colonic disease. Definitive management can be challenging due to advanced age co-morbidity seen this group patients. We describe patient successfully managed with on-table endoscopy and, under local anaesthetic, left iliac fossa trephine loop...
While major bile duct injury is the most serious complication following laparoscopic cholecystectomy, leak from cystic stump remains commonest morbidity. This a retrospective assessment of all patients who had cholecystectomy over 5-year period April 2003 to March 2008.Data related leakage were obtained Unisoft endoscopic retrograde cholangio-pancreatography (ERCP) database.Overall 2011 cholecystectomies performed, which 488 done as emergency procedures. Thirteen significant leakage, three...