A5065181637- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Function and Risk Factors
- Advanced Neuroimaging Techniques and Applications
- Cardiac electrophysiology and arrhythmias
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Ischemia and Reperfusion
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Arrhythmias and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Functional Brain Connectivity Studies
- Cardiovascular Disease and Adiposity
- COVID-19 and healthcare impacts
- Colorectal Cancer Surgical Treatments
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Viral Infections and Immunology Research
- Atomic and Subatomic Physics Research
- Dementia and Cognitive Impairment Research
- Cardiac Arrest and Resuscitation
Spanish National Centre for Cardiovascular Research
2015-2025
Philips (Spain)
2016-2025
Iberia (Spain)
2016-2025
Universidad de las Américas
2024
Hospital Recoletas Campo Grande
2024
Science and Technology Corporation for Naval, Maritime and Riverine Industry Development
2024
Instituto de Salud Carlos III
2017-2022
Instituto de Investigación Biomédica de Málaga
2022
Fundación José Ortega y Gasset-Gregorio Marañón
2022
University of Birmingham
2020-2021
Background— Data are limited on the presence, distribution, and extent of subclinical atherosclerosis in middle-aged populations. Methods Results— The PESA (Progression Early Subclinical Atherosclerosis) study prospectively enrolled 4184 asymptomatic participants 40 to 54 years age (mean age, 45.8 years; 63% male) evaluate systemic carotid, abdominal aortic, iliofemoral territories by 2-/3-dimensional ultrasound coronary artery calcification computed tomography. atherosclerosis, defined as...
Anthracycline-induced cardiotoxicity is a major clinical problem, and early markers are needed. The purpose of this study was to identify doxorubicin-induced by serial multiparametric cardiac magnetic resonance (CMR) its pathological correlates in large animal model. Twenty pigs were included. Of these, 5 received biweekly intracoronary doxorubicin doses (0.45 mg/kg/injection) followed until sacrifice at 16 weeks. Another 3 A third group sacrificed after the dose. All groups underwent weekly...
It is widely accepted that edema occurs early in the ischemic zone and persists stable form for at least 1 week after myocardial ischemia/reperfusion. However, there are no longitudinal studies covering from very (minutes) to late (1 week) reperfusion stages confirming this phenomenon.This study sought perform a comprehensive imaging histological characterization of edematous reaction experimental ischemia/reperfusion.The population consisted 25 instrumented Large-White pigs (30 kg 40 kg)....
Atherosclerosis is a systemic disease that frequently begins early in life. However, knowledge about the temporal dynamics (ie, progression or regression) of human subclinical atherosclerosis and their determinants scarce. This study sought to investigate within cohort middle-aged, asymptomatic individuals by using multiterritorial 3-dimensional vascular ultrasound (3DVUS) imaging. A total 3,471 participants from PESA (Progression Early Subclinical Atherosclerosis) (baseline age 40-55 years;...
<h3>BACKGROUND AND PURPOSE: </h3> The quantification and clinical significance of WD in CSTs following supratentorial stroke are not well understood. We evaluated the anisotropy by using DTI signal-intensity changes on conventional MR imaging CST to determine whether these findings correlated with limb motor deficit patients MCA ischemic stroke. <h3>MATERIALS METHODS: studied 60 within 12 hours onset. At admission, day 3, 30 evolution, underwent multimodal imaging, including sequences....
Abstract Recent functional neuroimaging studies have shown differences in brain activation between mathematically gifted adolescents and controls. The aim of this study was to investigate the relationship mathematical giftedness, intelligent quotient (IQ), microstructure white matter tracts a sample composed math‐gifted aged‐matched Math‐gifted subjects were selected through national program based on detecting enhanced visuospatial abilities creative thinking. We used diffusion tensor...
Post-ischemia/reperfusion (I/R) myocardial edema was recently shown to follow a consistent bimodal pattern: an initial wave of appears on reperfusion and dissipates at 24 h, followed by deferred that initiates days after infarction, peaking 1 week.This study examined the pathophysiology underlying this post-I/R edematous reaction.Forty instrumented pigs were assigned different infarction protocols. Edematous reaction evaluated water content quantification, serial cardiac magnetic resonance...
Background and Purpose— Nearly 50% of patients have residual motor deficits after stroke, long-term outcome is difficult to predict. We assessed the predictive value axonal damage corticospinal tract indexed by diffusion tensor imaging fractional anisotropy for outcome. Methods— Consecutive with middle cerebral artery stroke underwent multimodal MRI, including ≤12 hours, 3 days, 30 days onset. Clinical severity, infarct volume, location on tractography, ratios (rFA) between affected...
Clinical protocols aimed to characterize the post-myocardial infarction (MI) heart by cardiac magnetic resonance (CMR) need be standardized take account of dynamic biological phenomena evolving early after index ischemic event. Here, we evaluated time course edema reaction in patients with ST-segment-elevation MI CMR and assessed its implications for myocardium-at-risk (MaR) quantification both a large-animal model.A total 16 anterior successfully treated primary angioplasty matched controls...
Pre-reperfusion administration of intravenous (IV) metoprolol reduces infarct size in ST-segment elevation myocardial infarction (STEMI). This study sought to determine how this cardioprotective effect is influenced by the timing therapy having either a long or short bolus-to-reperfusion interval. We performed post hoc analysis METOCARD-CNIC (effect METOprolol CARDioproteCtioN during an acute InfarCtion) trial, which randomized anterior STEMI patients IV control before mechanical...
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder with important vascular and hemostatic alterations that should be taken into account during diagnosis treatment. This study evaluates whether anticoagulation dabigatran, clinically approved oral direct thrombin inhibitor low risk of intracerebral hemorrhage, ameliorates AD pathogenesis in transgenic mouse model AD. TgCRND8 mice their wild-type littermates were treated for 1 year dabigatran etexilate or placebo. Cognition...
Experimental studies suggest that increased bone marrow (BM) activity is involved in the association between cardiovascular risk factors and inflammation atherosclerosis. However, human data to support this are sparse. The purpose was study factors, BM activation, subclinical atherosclerosis.Whole body vascular 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI) performed 745 apparently healthy individuals [median age 50.5 (46.8-53.6) years, 83.8%...
The impact of method anastomosis and minimally invasive surgical technique on clinical outcomes after right hemicolectomy is uncertain. aim the MIRCAST study was to compare intracorporeal extracorporeal (ICA ECA respectively), each using either a laparoscopic approach or robot-assisted surgery during hemicolectomies for benign malignant tumours.This an international, multicentre, prospective, observational, monitored, non-randomized, parallel, four-cohort (laparoscopic ECA; ICA; ICA)....
Background: Several T2-mapping sequences have been recently proposed to quantify myocardial edema by providing T2 relaxation time values.However, no sequence has ever validated against actual water content for detection.In addition, these are either timeconsuming or require specialized software data acquisition and/or post-processing, factors impeding their routine clinical use.Our objective was obtain in vivo validation of a fast and accurate (T2 gradient-spin-echo [GraSE]) that can be...
The impact of cardioprotective strategies and ischemia duration on postischemia/reperfusion (I/R) myocardial tissue composition (edema, myocardium at risk, infarct size, salvage, intramyocardial hemorrhage, microvascular obstruction) is not well understood.To study the effect protective interventions temporal dynamics in a translational animal model I/R by use state-of-the-art imaging technology.Four 5-pig groups underwent different protocols: 40-minute (prolonged ischemia, controls),...
Left ventricular (LV) hypertrabeculation fulfilling noncompaction cardiomyopathy criteria has been detected in athletes. However, the association between LV (LVNC) phenotype and vigorous physical activity (VPA) general population is disputed. The aim of this study was to assess relationship LVNC on cardiac magnetic resonance (CMR) imaging accelerometer-measured (PA) a cohort middle-aged nonathlete participants PESA (Progression Early Subclinical Atherosclerosis) study. In (n = 4,184 subjects...