A5026504610- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
- Acute Myocardial Infarction Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Lipids, and Metabolism
- Cardiac Arrhythmias and Treatments
- Coronary Interventions and Diagnostics
- Heart Failure Treatment and Management
- Atherosclerosis and Cardiovascular Diseases
- COVID-19 Clinical Research Studies
- Advanced MRI Techniques and Applications
- Cardiac Fibrosis and Remodeling
- Cardiovascular Health and Disease Prevention
- Mechanical Circulatory Support Devices
- Pomegranate: compositions and health benefits
- Cholesterol and Lipid Metabolism
- Platelet Disorders and Treatments
- Cardiac Structural Anomalies and Repair
- Antioxidant Activity and Oxidative Stress
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2018-2025
Spanish National Centre for Cardiovascular Research
2021-2025
Hospital de Sant Pau
2014-2025
Hospital Clínic de Barcelona
2017-2024
Universitat de Barcelona
2018-2023
University Hospital Centre Zagreb
2023
University of Zagreb
2023
Institut d'Investigacions Biomèdiques de Barcelona
2019-2022
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017-2022
Instituto de Salud Carlos III
2022
Atherosclerosis is a systemic disease that frequently begins early in life. However, knowledge about the temporal dynamics (ie, progression or regression) of human subclinical atherosclerosis and their determinants scarce. This study sought to investigate within cohort middle-aged, asymptomatic individuals by using multiterritorial 3-dimensional vascular ultrasound (3DVUS) imaging. A total 3,471 participants from PESA (Progression Early Subclinical Atherosclerosis) (baseline age 40-55 years;...
Clonal hematopoiesis, a condition in which acquired somatic mutations hematopoietic stem cells lead to the outgrowth of mutant clone, is associated with higher risk hematological cancer and growing list nonhematological disorders, most notably atherosclerosis cardiovascular disease. However, whether accelerated cause or consequence clonal hematopoiesis remains matter debate. Some studies support direct contribution certain hematopoiesis-related via exacerbation inflammatory responses,...
The age-standardized death rates under 65 years from ischemic heart disease in South Eastern Europe are approximately twice as high than the Western average, but reasons not completely recognized. aim of present study was to address this issue by collecting and analyzing data a large, multinational cohort.
Abstract Aims Recurrent acute myocardial infarction (RE-AMI) is a frequent complication after STEMI, and its association with stent thrombosis can be life-threatening. Intravenous atorvastatin (IV-atorva) administration during AMI has been shown to limit infarct size adverse cardiac remodeling. We determined by magnetic resonance (CMR) whether the cardioprotection exerted IV-atorva at index event translates into better prognosis upon RE-AMI in dyslipidemic pigs. Methods Results...
P2Y12 antagonists are the standard in antiplatelet therapy but their potential effects on functional myocardial recovery and cardioprotection post-myocardial infarction (MI) unknown. We investigated a preclinical model of MI whether ticagrelor clopidogrel differently affect cardiac repair post-MI.Pigs either received: (i) (600 mg; 75 mg/qd); (ii) (180 90 mg/bid); (iii) placebo control. was induced by mid-left anterior descending coronary artery balloon occlusion (60 min) animals received...
Beyond lipid-lowering, statins exert cardioprotective effects. High-dose statin treatment seems to reduce cardiovascular complications in high-risk patients. The ideal timing and administration regime remain unknown. This study compared the effects of intravenous during myocardial infarction (MI) with oral immediately post-MI. Hypercholesterolemic pigs underwent MI induction (90 min ischemia) were kept for 42 days. Animals distributed 3 arms (A): A1 received an bolus atorvastatin MI; A2...
Obesity is associated with metabolic disorders such as insulin resistance and type 2 diabetes mellitus (T2DM), further increasing an already heightened cardiovascular risk. Here, amongst obese class III bariatric surgery patients, we have investigated the effect of T2DM in serum two, same patient, adipose tissue (AT) depots through proteomic profile expression analyses. Serum AT samples from subcutaneous (SAT) visceral (VAT) fat were collected during surgery. Bead-based targeted multiplex...
Abstract Aims High-density lipoproteins (HDLs) are circulating micelles that transport proteins, lipids, and miRNAs. HDL-transported miRNAs (HDL-miRNAs) have lately received attention but their effects on vascular cells not fully understood. Additionally, whether cardiovascular risk factors affect HDL-miRNAs levels miRNA transfer to recipient remains equally poorly known. Here, we investigated the changes induced by hypercholesterolaemia HDL-miRNA its effect endothelial (ECs). Methods...
There have been conflicting reports regarding outcomes in women presenting with an acute coronary syndrome (ACS).
Dyslipidaemia, inflammation and elevated Lp(a) levels are associated with the progression of atherosclerosis. This study investigates whether patients a first-time presentation chest pain on-target LDL-C intermediate FRS/ESC-Score risks, display high inflammatory burden linked to myocardial injury at admission affects re-event rate up 6 years follow-up.
Inhibitors of SGLT2 (SGLT2i) have shown a positive impact in patients with chronic heart failure and reduced ejection fraction (HFrEF). Nonetheless, the direct effects SGLT2i on cardiac cells how their association main drugs used for HFrEF affect behaviour signalling pathways myocardial fibroblasts are still unknown. We aimed to determine dapagliflozin alone combination sacubitril/valsartan (LCZ696) or spironolactone function (HFrEF).Myocardial isolated from (n = 5) were treated (1 nM-1 μM)...