A5040039501- Diabetes Management and Research
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Metabolism, Diabetes, and Cancer
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- MicroRNA in disease regulation
- Canadian Identity and History
- Adipose Tissue and Metabolism
- Multiculturalism, Politics, Migration, Gender
- Chronic Disease Management Strategies
- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
- Diabetes Management and Education
- Education, sociology, and vocational training
- Health and Lifestyle Studies
- Cardiac Imaging and Diagnostics
- Peroxisome Proliferator-Activated Receptors
- Environmental Justice and Health Disparities
- Diet and metabolism studies
- Atherosclerosis and Cardiovascular Diseases
- Cultural Identity and Heritage
- Arsenic contamination and mitigation
- Lipid metabolism and disorders
Instituto de Investigación Sanitaria del Principado de Asturias
2022-2025
Gobierno del Principado de Asturias
2023-2024
Universidad de Oviedo
2024
Universitat de Barcelona
2022-2023
Central University Hospital of Asturias
2023
Hospital de Sant Pau
2018-2023
McGill University
1975-2021
Centro de Investigación en Red en Enfermedades Cardiovasculares
2017
Abstract Type 1 diabetes is a chronic autoimmune disease which results in inefficient regulation of glucose homeostasis and can lead to different vascular comorbidities through life. In this study we aimed analyse the circulating miRNA expression profile patients with type diabetes, no other associated pathology. For this, fasting plasma was obtained from 85 subjects. Next generation sequencing analysis firstly performed identify miRNAs that were differentially expressed between groups (20...
The 72-hour fasting test remains the standard for diagnosis of endogenous hyperinsulinism. We investigated which variables could identify patients at low risk hyperinsulinism, in whom a shortening be considered. This multicenter, retrospective study included 64 individuals (46 women, median age 45 years) without diabetes who underwent tests etiologic hypoglycemia. Pre- and intra-test were collected, including point-of-care glucose trajectories during test. Testing was stopped before 72 h if...
Sodium-glucose-linked transporter 2 inhibitors (SGLT2i) may have antitumor effects. Previous studies analyzing their role in mortality and progression did not account for potential confounders, including cancer treatment, performance status, inflammatory markers, nutritional status. This study aims to evaluate the impact of SGLT2i treatment on while considering these confounders. A retrospective cohort was conducted. total 526 patients with (302 women, mean age 64 years, range 40-79 years)...
P2Y12 antagonists are the standard in antiplatelet therapy but their potential effects on functional myocardial recovery and cardioprotection post-myocardial infarction (MI) unknown. We investigated a preclinical model of MI whether ticagrelor clopidogrel differently affect cardiac repair post-MI.Pigs either received: (i) (600 mg; 75 mg/qd); (ii) (180 90 mg/bid); (iii) placebo control. was induced by mid-left anterior descending coronary artery balloon occlusion (60 min) animals received...
Obesity is associated with metabolic disorders such as insulin resistance and type 2 diabetes mellitus (T2DM), further increasing an already heightened cardiovascular risk. Here, amongst obese class III bariatric surgery patients, we have investigated the effect of T2DM in serum two, same patient, adipose tissue (AT) depots through proteomic profile expression analyses. Serum AT samples from subcutaneous (SAT) visceral (VAT) fat were collected during surgery. Bead-based targeted multiplex...
Cardiovascular disease (CVD) remains one of the major causes death and disability worldwide. In addition to drug treatment, nutritional interventions or supplementations are becoming a health strategy for CVD prevention. Phytosterols (PhyS) natural components that have been shown reduce cholesterol levels; while poly-unsaturated fatty acids (PUFA), mainly omega-3 (ω3) acids, triglyceride levels. Here we aimed investigate whether proteins in main lipoproteins (low density (LDL) high (HDL)) as...
Patients with type 2 diabetes mellitus (T2DM) have a higher incidence of cardiovascular (CV) events. The ingestion high-glycemic index (GI) diets, specially sweetened beverage consumption, has been associated the development T2DM and CV disease.We investigated effects intake beverage, obtained from natural carbohydrates containing pinitol (PEB) compared to sucrose-enriched (SEB) in context impaired glucose tolerance (IGT) diabetes.The study was divided three different phases: (1) discovery...
The term diabetes first emerged in the 3rd century BC, a reference by Demetrius of Apamea, who described disease as dropsy which any liquid ingested is eliminated form urine. However, great discovery that revolutionized this field came from Canadian doctor Frederick Banting, together with his student and assistant Charles Best, managed to isolate insulin treat patient on 23 January 1922. This was Leonard Thompson, results obtained him were surprising. His glycosuria ketonuria disappeared...
Abstract Background Previous research has indicated that hypoglycemia during hospitalization is a predictor of unfavorable outcomes in patients with diabetes. However, no studies have examined the long-term impact adults admitted for hyperglycemic crises. The study was aimed to investigate implications hyperosmolar crises, particularly terms all-cause mortality. Methods This retrospective cohort included 170 (82 men [48.2%], median age 72 years) university hospital including pure states and...
The composition and function of the adipose tissue covering heart are poorly known. In this study, we have investigated epicardial (EAT) cardiac ventricular muscle EAT left anterior descending artery (LAD) on human heart, to identify their resident stem cell functional activity.EAT was isolated from apex (avoiding areas irrigated by major vessels) (ventricular myocardium (VMAT)) area arterial sulcus LAD (PVAT) in hearts excised during transplant surgery. Adipose cells (ASCs) both depots were...
Gestational diabetes mellitus (GDM) is defined as any degree of glucose intolerance that diagnosed for the first time during pregnancy. The objective this study to know tolerance status after 15 years pregnancy in patients with gestational and assess long-term effect GDM on circulating miRNA profile these women. To answer these, 30 randomly selected women 2005-2006 were included study, was measured using National Diabetes Data Group criteria. Additionally, four miRNAs (hsa-miR-1-3p,...
Introduction Most of the disease-associated single nucleotide polymorphisms (SNPs) lie in non- coding regions human genome. Many these variants have been predicted to impact expression and function long non-coding RNAs (lncRNA), but contribution molecules development complex diseases remains be clarified. Methods Here, we performed a genetic association study between SNP located lncRNA known as LncTGM2 risk developing type 2 diabetes (T2D), analyzed its implication disease pathogenesis at...
The increase in the incidence of obesity and obesity-related cardiovascular risk factors (CVRFs) over last decades has brought attention on adipose tissue (AT) pathobiology. expansion AT is associated with development new vasculature needed to perfuse tissue; however, not all fat depots have same ability induce angiogenesis that requires recruitment their own endothelial cells. In this study we investigated effect different CVRFs, angiogenic capacity subcutaneous (SAT) visceral (VAT)...
The risk factors for hypoglycemia during hospital admission and its consequences in patients with diabetes are not entirely known. present study aimed to investigate the hypoglycemia, as well potential implications of type 2 mellitus admitted hospital.This retrospective cohort included 324 (214 [66.0%] men; median age 70 years, range 34-95 years) a university who were consulted Endocrinology Department glycemic control 12-month period. We investigated role demographic factors, metabolic...
Metformin is a well-established drug for the treatment of type 2 diabetes; however, mechanism action has not been well described and many aspects how it truly acts are still unknown. Moreover, regarding in vitro experiments, glycaemic status when metformin used generally considered, which, added to suprapharmacological concentrations that commonly employed research, resulted gaps its action. The aim this study was determine glucose influence cell culture. Considering diabetic retinopathy one...
A recent consensus report on hyperglycemic crises included recommendations for calculating the subcutaneous insulin dose when transitioning from intravenous insulin. In 95 patients admitted hyperosmolar crisis, there were no significant differences in post-transition glycemic control between who met and those did not.
Abstract Background Differentiating between type 1 diabetes (T1D) and 2 (T2D) can be difficult in adults. The aim of this study was to determine the frequency diagnostic reclassification from T2D T1D, characteristics patients impact on management disease. Methods Observational descriptive including diagnosed with T1D Asturias (Spain) 2011 2020 who had been considered as for at least 12 months. Results A total 205 were included, representing 45.3% those over 30 years age. Median time...