A5101464053- Plant-Microbe Interactions and Immunity
- Plant Pathogenic Bacteria Studies
- Plant pathogens and resistance mechanisms
- Legume Nitrogen Fixing Symbiosis
- Social Sciences and Policies
- Plant Reproductive Biology
- Plant Parasitism and Resistance
- Plant Stress Responses and Tolerance
- Salmonella and Campylobacter epidemiology
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Arsenic contamination and mitigation
- Plant Gene Expression Analysis
- Female Genital Mutilation/Cutting Issues
- Plant Molecular Biology Research
- Genital Health and Disease
- Photosynthetic Processes and Mechanisms
- Gastrointestinal Tumor Research and Treatment
- Labor Law and Work Dynamics
- Essential Oils and Antimicrobial Activity
- Cutaneous Melanoma Detection and Management
- Violence, Education, and Gender Studies
- Cancer-related molecular mechanisms research
- Listeria monocytogenes in Food Safety
- Galectins and Cancer Biology
Instituto de Investigación Sanitaria del Principado de Asturias
2024-2025
Gobierno del Principado de Asturias
2023-2024
University of Tampa
2024
Max Planck Institute for Plant Breeding Research
2008-2016
Centre National de la Recherche Scientifique
2011-2014
Université d'Évry Val-d'Essonne
2012-2014
Unité de Recherche Pluridisciplinaire Prairies et Plantes Fourragères
2011
Max Planck Society
2009-2010
Plant stomata function in innate immunity against bacterial invasion and abscisic acid (ABA) has been suggested to regulate this process. Using genetic, biochemical, pharmacological approaches, we demonstrate that (i) the Arabidopsis thaliana nine-specific-lipoxygenase encoding gene, LOX1, which is expressed guard cells, required trigger stomatal closure response both bacteria pathogen-associated molecular pattern flagellin peptide flg22; (ii) LOX1 participates defense; (iii) polyunsaturated...
Abstract Plant immune responses depend on dynamic signaling events across the nuclear envelope through pores. Nuclear accumulation of certain resistance (R) proteins and downstream signal transducers are critical for their functions, but it is not understood how these processes controlled. Here, we report identification, cloning, analysis Arabidopsis thaliana modifier snc1,7 (mos7-1), a partial loss-of-function mutation that suppresses conditioned by autoactivated R protein snc1 (for...
An important layer of plant innate immunity to host-adapted pathogens is conferred by intracellular nucleotide-binding/oligomerization domain-leucine rich repeat (NB-LRR) receptors recognizing specific microbial effectors. Signaling from activated the TIR (Toll/Interleukin-1 Receptor)-NB-LRR class converges on nucleo-cytoplasmic immune regulator EDS1 (Enhanced Disease Susceptibility1). In this report we show that a receptor-stimulated increase in accumulation nuclear precedes or coincides...
Plant growth is influenced by genetic factors and environmental cues. Genotype-by-environment interactions are governed complex epistatic networks that subject to natural selection. Here we describe a novel interaction modulating in response temperature common 2 Arabidopsis recombinant inbred line (RIL) populations (Ler x Kas-2 Ler Kond). At 14 degrees C, lines with specific allele combinations at interacting loci (incompatible interactions) have severe defects. These exhibit deregulated...
Plant mitogen-activated protein kinases (MAPKs) are involved in important processes, including stress signaling and development. In a functional yeast screen, we identified mutations that render Arabidopsis thaliana MAPKs constitutively active (CA). Importantly, CA-MAPKs maintain their specificity toward known activators substrates. As proof-of-concept, MAPK4 (MPK4) function plant immunity was investigated. agreement with the phenotype of mpk4 mutants, CA-MPK4 plants were compromised...
Abstract Background Mitogen-activated protein kinases (MAPKs) are key regulators of immune responses in animals and plants. In Arabidopsis , perception microbe-associated molecular patterns (MAMPs) activates the MAPKs MPK3, MPK4 MPK6. Increasing information depicts events activated by MAMPs plants, but specific cooperative contributions these signalling largely unclear. Results this work, we analyse behaviour MPK3 MPK6 mutants early late triggered MAMP flg22 from bacterial flagellin. A...
Salmonella virulence in animals depends on effectors injected by Type III Secretion Systems (T3SSs). In this report we demonstrate that mutants are unable to deliver also compromised infection of Arabidopsis thaliana plants. Transcriptome analysis revealed contrast wild type bacteria, T3SS suppressing highly conserved genes play a prominent role during animals. We found originating from infected plants equally virulent for human cells and mice. These results indicate high degree conservation...
Abstract Type 1 diabetes is a chronic autoimmune disease which results in inefficient regulation of glucose homeostasis and can lead to different vascular comorbidities through life. In this study we aimed analyse the circulating miRNA expression profile patients with type diabetes, no other associated pathology. For this, fasting plasma was obtained from 85 subjects. Next generation sequencing analysis firstly performed identify miRNAs that were differentially expressed between groups (20...
Plants have a large panel of nucleotide-binding/leucine rich repeat (NLR) immune receptors which monitor host interference by diverse pathogen molecules (effectors) and trigger disease resistance pathways. NLR receptor systems are necessarily under tight control to mitigate the trade-off between induced defenses growth. Hence, mis-regulated NLRs often cause autoimmunity associated with stunting and, in severe cases, necrosis. Nucleocytoplasmic ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1) is...
Controlled nucleocytoplasmic trafficking is an important feature for fine-tuning signaling pathways in eukaryotic organisms. Nuclear pore complexes (NPCs) composed of nucleoporin proteins (Nups) are essential the exchange macromolecules across nuclear envelope. A recent genetic screen our laboratory identified a partial loss-of-function mutation Arabidpsis MOS7/Nup88 that causes defects basal immunity, Resistance (R) protein-mediated defense and systemic acquired resistance. In Drosophila...
Abstract Background Previous research has indicated that hypoglycemia during hospitalization is a predictor of unfavorable outcomes in patients with diabetes. However, no studies have examined the long-term impact adults admitted for hyperglycemic crises. The study was aimed to investigate implications hyperosmolar crises, particularly terms all-cause mortality. Methods This retrospective cohort included 170 (82 men [48.2%], median age 72 years) university hospital including pure states and...
Metformin is a well-established drug for the treatment of type 2 diabetes; however, mechanism action has not been well described and many aspects how it truly acts are still unknown. Moreover, regarding in vitro experiments, glycaemic status when metformin used generally considered, which, added to suprapharmacological concentrations that commonly employed research, resulted gaps its action. The aim this study was determine glucose influence cell culture. Considering diabetic retinopathy one...
The small molecule DFPM ([5-(3,4-dichlorophenyl)furan-2-yl]-piperidine-1-ylmethanethione) was recently shown to trigger signal transduction via early effector-triggered immunity signaling genes including EDS1 and PAD4 in Arabidopsis thaliana accession Col-0. Chemical genetic analyses of A. natural variants identified the plant Resistance protein-like Toll/Interleukin1 Receptor (TIR)-Nucleotide Binding (NB)-Leucine-Rich Repeat (LRR) protein VICTR as required for DFPM-mediated root growth...
Abstract Batrachochytrium dendrobatidis (Bd), an aquatic pathogenic fungus, is responsible for the decline of hundreds amphibian species worldwide and negatively impacts biodiversity globally. Prophylactic exposure to metabolites produced by Bd can provide protection naïve tree frogs reduce subsequent infection intensity. Here, we used a response surface design crossing metabolite prophylaxis concentration duration determine how these factors modulate prophylactic against in Pacific chorus...
This study aims to investigate the differential miRNA expression profile between visceral white adipose tissue and skeletal muscle of people with obesity undergoing bariatric surgery. Skeletal samples 10 controls 38 (50% also type 2 diabetes) surgery were collected. profiles analyzed using Next-Generation Sequencing subsequently validated RT-PCR. Approximately 69% miRNAs showed similar in both tissues, however, 55 preferentially expressed 53 muscle. miR-122b-5p was uniquely identified...