Margaret R. Karagas
A5062649421- Epigenetics and DNA Methylation
- Heavy Metal Exposure and Toxicity
- Bladder and Urothelial Cancer Treatments
- Arsenic contamination and mitigation
- Birth, Development, and Health
- Air Quality and Health Impacts
- Gut microbiota and health
- Nutritional Studies and Diet
- Nonmelanoma Skin Cancer Studies
- Environmental Justice and Health Disparities
- Health, Environment, Cognitive Aging
- Cutaneous Melanoma Detection and Management
- Digestive system and related health
- Hedgehog Signaling Pathway Studies
- Effects and risks of endocrine disrupting chemicals
- Genetic Associations and Epidemiology
- Urinary and Genital Oncology Studies
- RNA modifications and cancer
- Skin Protection and Aging
- Heavy metals in environment
- Trace Elements in Health
- Pregnancy and preeclampsia studies
- Mercury impact and mitigation studies
- Folate and B Vitamins Research
- Child Nutrition and Water Access
Dartmouth College
2016-2025
RTI International
2024
Northern Arizona University
2024
Johns Hopkins University
2024
Pennsylvania State University
2024
Cohort (United Kingdom)
2024
Dartmouth Hospital
2011-2023
Dartmouth Psychiatric Research Center
2012-2023
University of Maryland, Baltimore
2023
Dartmouth–Hitchcock Medical Center
2007-2022
Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations epigenetic marks such as DNA methylation have been linked to cancers many other diseases, interindividual variations in tissues due aging, environmental factors, or innate susceptibility are poorly characterized. The plasticity, tissue-specific nature, variability expression related epigenomic states that vary across individuals. Thus, population-based...
Current knowledge regarding the basic epidemiology of fractures is largely limited to a few fracture sites, notably those hip and distal forearm. To clarify patterns incidence limb in elderly, we used data from 5% sample U.S. Medicare population over age 65 years during 1986-1990. We identified incident proximal humerus, other parts radius/ulna, shaft pelvis, hip, femur, patella, ankle, tibia/fibula diagnoses procedures coded on claims for inpatient services, outpatient facility use,...
Emerging data indicate that rice consumption may lead to potentially harmful arsenic exposure. However, few human are available, and virtually none exist for vulnerable periods such as pregnancy. Here we document a positive association between urinary excretion, biomarker of recent exposure, in 229 pregnant women. At 6-mo prenatal visit, collected urine sample 3-d dietary record water, fish/seafood, rice. We also tested women's home tap water arsenic, which combined with estimate exposure...
ABSTRACT Pulmonary damage caused by chronic colonization of the cystic fibrosis (CF) lung microbial communities is proximal cause respiratory failure. While there has been an effort to document microbiome CF in pediatric and adult patients, little known regarding developing microflora infants. We examined intestinal microbiota development infants with from birth 21 months. Distinct genera dominated gut compared those tract, yet some bacteria overlapped, demonstrating a core Veillonella...
The intestinal microbiome plays a critical role in infant development, and delivery mode feeding method (breast milk vs formula) are determinants of its composition. However, the importance beyond first days life is unknown, studies associations between composition have been generally limited to comparisons exclusively breastfed formula-fed infants, with little consideration given combination both breast formula.To examine at approximately 6 weeks life.Prospective observational study 102...
Hexavalent chromium is a known carcinogen when inhaled, but its carcinogenic potential orally ingested remains controversial. Water contaminated with hexavalent worldwide problem, making this question of significant public health importance. We conducted an ecological mortality study within the Oinofita region Greece, where water has been chromium. calculated gender, age, and period standardized ratios (SMRs) for all deaths, cancer specific types residents over 11-year (1999 - 2009), using...
The potential influence of underlying differences in relative leukocyte distributions studies involving blood-based profiling DNA methylation is well recognized and has prompted development a set statistical methods for inferring changes the distribution white blood cells using signatures. However, extent to which this methodology can accurately predict cell-type proportions based on blood-derived data large-scale epigenome-wide association study (EWAS) yet be examined. We used publicly...
The gut microbiome has an important role in infant health and immune development may be affected by early-life exposures. Maternal diet influence the through vertical transfer of maternal microbes to infants during vaginal delivery breastfeeding. We aimed examine association pregnancy with 6 weeks post-delivery mother-infant dyads enrolled New Hampshire Birth Cohort Study. Infant stool samples were collected from 145 infants, prenatal was assessed using a food frequency questionnaire. used...
Abstract The Environmental Influences on Child Health Outcomes (ECHO)-Wide Cohort Study (EWC), a collaborative research design comprising 69 cohorts in 31 consortia, was funded by the National Institutes of (NIH) 2016 to improve children’s health United States. EWC harmonizes extant data and collects new using standardized protocol, ECHO-Wide Data Collection Protocol (EWCP). EWCP visits occur at least once per life stage, but frequency timing vary across cohorts. As March 4, 2022,...
Prenatal chemical exposures can influence maternal and child health; however, few industrial chemicals are routinely biomonitored. We assessed an extensive panel of contemporary emerging in 171 pregnant women across the United States (U.S.) Puerto Rico Environmental influences on Child Health Outcomes (ECHO) Program. simultaneously measured urinary concentrations 89 analytes (103 total representing 73 parent compounds) nine groups: bactericides, benzophenones, bisphenols, fungicides...
Importance The COVID-19 pandemic led to widespread lockdowns and school closures that may have affected screen time among children. Although restrictions were strongest early in the pandemic, it is unclear how changed as progressed. Objective To evaluate change children’s from before during July 2019 through August 2021. Design, Setting, Participants This a longitudinal cohort study with repeated measures of collected 2 periods. Children aged 4 12 years their parent enrolled 3 pediatric...
Background: Per- and polyfluoroalkyl substances (PFAS) are persistent ubiquitous chemicals associated with risk of adverse birth outcomes. Results previous studies have been inconsistent. Associations between PFAS outcomes may be affected by psychosocial stress. Objectives: We estimated in relation to prenatal concentrations evaluate whether maternal stress modifies those relationships. Methods: included 3,339 participants from 11 prospective cohorts the Environmental influences on Child...
We conducted a study to estimate the current incidence rates of basal-cell carcinoma (BCC) and squamous-cell (SCC) skin in population New Hampshire (NH), USA, quantify recent changes these malignancies. BCCs SCCs diagnosed among NH residents were identified through physician practices central pathology laboratories bordering regions from June 1979 May 1980 July 1993 1994. For each diagnosis period, we estimated age-adjusted for both BCC SCC men women separate anatomic sites. Between...
<h3>Objective.</h3> —The primary aims of this study were to assess risk subsequent basal and squamous cell skin cancer among patients with a prior history these tumors examine risks in relation patient characteristics life-style factors. <h3>Design.</h3> —Follow-up participants randomized trial betacarotene as possible preventive agent. <h3>Setting.</h3> —Clinical centers Los Angeles, Calif, San Francisco, Minneapolis, Minn, Hanover, NH. <h3>Participants.</h3> —Patients (n=1805) who...