A5038452276- Autism Spectrum Disorder Research
- Child Nutrition and Feeding Issues
- Birth, Development, and Health
- Congenital heart defects research
- Health, Environment, Cognitive Aging
- Child Nutrition and Water Access
- Epigenetics and DNA Methylation
- Folate and B Vitamins Research
- Effects and risks of endocrine disrupting chemicals
- Family and Disability Support Research
- Breastfeeding Practices and Influences
- Per- and polyfluoroalkyl substances research
- Child Development and Digital Technology
- Genetics and Neurodevelopmental Disorders
- Air Quality and Health Impacts
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Maternal Mental Health During Pregnancy and Postpartum
- Prenatal Screening and Diagnostics
- Toxic Organic Pollutants Impact
- Pregnancy and preeclampsia studies
- Infant Development and Preterm Care
- Energy and Environment Impacts
- Genomic variations and chromosomal abnormalities
- Health disparities and outcomes
University of California, Davis
2016-2025
NeuroDevelopment Center
2024
California Department of Public Health
2016-2024
Cohort (United Kingdom)
2024
Wayne State University
2024
Rutgers, The State University of New Jersey
2024
Columbia University
2024
Northeastern University
2024
Avera Health
2024
University of South Dakota
2024
Gestational exposure to several common agricultural pesticides can induce developmental neurotoxicity in humans, and has been associated with delay autism.We evaluated whether residential proximity during pregnancy is autism spectrum disorders (ASD) or (DD) the Childhood Autism Risks from Genetics Environment (CHARGE) study.The CHARGE study a population-based case-control of ASD, DD, typical development. For 970 participants, commercial pesticide application data California Pesticide Use...
Causes of autism are unknown. Associations with maternal nutritional factors and their interactions gene variants have not been reported.Northern California families were enrolled from 2003 to 2009 in the CHARGE (CHildhood Autism Risks Genetics Environment) population-based case-control study. Children aged 24-60 months evaluated confirmed (n = 288), spectrum disorder 141), or typical development 278) at University California-Davis Medical Investigation Neurodevelopmental Disorders Institute...
Characterization of the epigenome is a primary interest for children's environmental health researchers studying influences on human populations, particularly those role pregnancy and early-life exposures later-in-life outcomes.Our objective was to consider state science in epigenetics research focus DNA methylation collective observations many studies being conducted within Children's Environmental Health Disease Prevention Research Centers, as they relate Developmental Origins (DOHaD)...
Prenatal chemical exposures can influence maternal and child health; however, few industrial chemicals are routinely biomonitored. We assessed an extensive panel of contemporary emerging in 171 pregnant women across the United States (U.S.) Puerto Rico Environmental influences on Child Health Outcomes (ECHO) Program. simultaneously measured urinary concentrations 89 analytes (103 total representing 73 parent compounds) nine groups: bactericides, benzophenones, bisphenols, fungicides...
Background: Per- and polyfluoroalkyl substances (PFAS) are persistent ubiquitous chemicals associated with risk of adverse birth outcomes. Results previous studies have been inconsistent. Associations between PFAS outcomes may be affected by psychosocial stress. Objectives: We estimated in relation to prenatal concentrations evaluate whether maternal stress modifies those relationships. Methods: included 3,339 participants from 11 prospective cohorts the Environmental influences on Child...
BackgroundChildhood maltreatment is associated with adverse health outcomes and this risk can be transmitted to the next generation. We aimed investigate association between exposure maternal childhood common physical mental problems, neurodevelopmental disorders, related comorbidity patterns in offspring.Methods.We conducted a retrospective cohort study using data from Environmental influences on Child Health Outcomes (ECHO) Program, which was launched influence of early life exposures...
BackgroundPhthalates are synthetic chemicals widely used in consumer products and have been identified to contribute preterm birth. Existing studies methodological limitations potential effects of di-2-ethylhexyl phthalate (DEHP) replacements poorly characterised. Attributable fractions costs not quantified, limiting the ability weigh trade-offs involved ongoing use. We aimed leverage a large, diverse US cohort study associations metabolites with birthweight gestational age, estimate...
The past decade has seen remarkable progress in identifying genes that, when impacted by deleterious coding variation, confer high risk for autism spectrum disorder (ASD), intellectual disability, and other developmental disorders. However, most underlying gene discovery efforts have focused on individuals of European ancestry, limiting insights into genetic risks across diverse populations. To help address this, the Genomics Autism Latin American Ancestries Consortium (GALA) was formed,...
Abstract Persistent organic pollutants (POPs), including polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) that bioaccumulate in lipid‐rich tissues are of concern as developmental neurotoxicants. Epigenetic mechanisms such DNA methylation act at the interface genetic environmental factors implicated autism‐spectrum disorders. The relationship between POP levels patterns individuals with without neurodevelopmental disorders has not been previously investigated. In...
Iron deficiency affects 40%–50% of pregnancies. is critical for early neurodevelopmental processes that are dysregulated in autism spectrum disorder (ASD). We examined maternal iron intake relation to ASD risk California-born children enrolled a population-based case-control study (the Childhood Autism Risks from Genetics and the Environment (CHARGE) Study) 2003 2009 with diagnosis (n = 520) or typical development 346) was clinically confirmed using standardized assessments. Mean daily...
Peginesatide is a peptide-based erythropoiesis-stimulating agent (ESA) that may have therapeutic potential for anemia in patients with advanced chronic kidney disease. We evaluated the safety and efficacy of peginesatide, as compared another ESA, darbepoetin, 983 such who were not undergoing dialysis.In two randomized, controlled, open-label studies (PEARL 1 2), received peginesatide once month, at starting dose 0.025 mg or 0.04 per kilogram body weight, darbepoetin every 2 weeks, 0.75 μg...
Background: Until recently, environmental factors in autism spectrum disorder (ASD) were largely ignored. Over the last decade, altered risks from lifestyle, medical, chemical, and other have emerged through various study designs: whole population cohorts linked to diagnostic and/or exposure-related databases, large case–control studies, smaller of children at elevated risk for ASD. Objectives: This aimed introduce MARBLES (Markers Autism Risk Babies—Learning Early Signs) prospective its...
Introduction: Our understanding of the association between coronavirus disease 19 (COVID-19) and preterm or early term birth among racially ethnically diverse populations people with chronic medical conditions is limited.Methods: We determined COVID-19 (PTB) live births documented by California Vital Statistics certificates July 2020 January 2021 (n=240,147). used best obstetric estimate gestational age to classify as very (VPTB, <32 weeks), PTB (< 37 (37 38 (39-44 each confer independent...
Maternal folic acid (FA) protects against developmental toxicity from certain environmental chemicals.We examined combined exposures to maternal FA and pesticides in relation autism spectrum disorder (ASD).Participants were California children born 2000-2007 who enrolled the Childhood Autism Risks Genetics Environment (CHARGE) case-control study at age 2-5 y, clinically confirmed have ASD (n=296) or typical development (n=220), had information on supplemental pesticide exposures. household...
<h3>Importance</h3> Maternal use of folic acid supplements has been inconsistently associated with reduced risk for autism spectrum disorder (ASD) in the child. No study to date examined this association context ASD recurrence high-risk families. <h3>Objective</h3> To examine between maternal prenatal vitamin and younger siblings children ASD. <h3>Design, Setting, Participants</h3> This prospective cohort analyzed data from a sample (n = 332) their mothers 305) enrolled MARBLES (Markers...
Autism spectrum disorder (ASD) is a neurodevelopmental with complex heritability and higher prevalence in males. The neonatal epigenome has the potential to reflect past interactions between genetic environmental factors during early development influence future health outcomes.
Phthalate exposure is widespread among pregnant women and may be a risk factor for preterm birth. To investigate the prospective association between urinary biomarkers of phthalates in pregnancy birth individuals living US. Individual-level data were pooled from 16 preconception studies conducted Pregnant who delivered 1983 2018 provided 1 or more urine samples during included. Urinary phthalate metabolites quantified as exposure. Concentrations 11 standardized dilution mean repeated...
Importance Physical and social neighborhood attributes may have implications for children’s growth development patterns. The extent to which these are associated with body mass index (BMI) trajectories obesity risk from childhood adolescence remains understudied. Objective To examine associations of neighborhood-level measures opportunity vulnerability BMI birth adolescence. Design, Setting, Participants This cohort study used data 54 cohorts (20 677 children) participating in the...
Autism spectrum disorder (ASD) involves complex genetics interacting with the perinatal environment, complicating discovery of common genetic risk. The epigenetic layer DNA methylation shows dynamic developmental changes and molecular memory in utero experiences, particularly placenta, a fetal tissue discarded at birth. However, current array-based methods to identify novel ASD risk genes lack coverage most structurally epigenetically variable regions human genome.