A5054009812- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Effects and risks of endocrine disrupting chemicals
- Preterm Birth and Chorioamnionitis
- Gestational Diabetes Research and Management
- Neonatal Respiratory Health Research
- Pregnancy and Medication Impact
- Reproductive System and Pregnancy
- Toxic Organic Pollutants Impact
- Pregnancy-related medical research
- Assisted Reproductive Technology and Twin Pregnancy
- Maternal and fetal healthcare
- Air Quality and Health Impacts
- Maternal and Perinatal Health Interventions
- Cancer Risks and Factors
- Pharmacological Effects and Toxicity Studies
- Prenatal Screening and Diagnostics
- Cardiovascular Issues in Pregnancy
- Per- and polyfluoroalkyl substances research
- Pelvic floor disorders treatments
- Maternal Mental Health During Pregnancy and Postpartum
- Health, Environment, Cognitive Aging
- Neonatal and fetal brain pathology
- Epilepsy research and treatment
- Vitamin D Research Studies
Harvard University
2016-2025
Brigham and Women's Hospital
2016-2025
Vanderbilt University
2010-2025
AbbVie (United States)
2025
Amherst College
2022
University of California, San Francisco
2015-2022
Community Link
2021
Massachusetts General Hospital
2001-2021
Stanford University
2019-2020
National Institute of Environmental Health Sciences
2017-2020
<h3>Importance</h3> Asthma and wheezing begin early in life, prenatal vitamin D deficiency has been variably associated with these disorders offspring. <h3>Objective</h3> To determine whether (cholecalciferol) supplementation can prevent asthma or recurrent wheeze childhood. <h3>Design, Setting, Participants</h3> The Vitamin Antenatal Reduction Trial was a randomized, double-blind, placebo-controlled trial conducted 3 centers across the United States. Enrollment began October 2009 completed...
<h3>Importance</h3> Preterm birth is a leading cause of neonatal mortality, with variety contributing causes and risk factors. Environmental exposures represent group understudied, but potentially important, Phthalate diesters are used extensively in consumer products worldwide. Consequently, exposure pregnant women highly prevalent. <h3>Objective</h3> To assess the relationship between phthalate during pregnancy preterm birth. <h3>Design, Setting, Participants</h3> This nested case-control...
Epidemiologists have grouped the multiple disorders that lead to preterm delivery before 28th week of gestation in a variety ways. The authors sought identify characteristics would help guide how classify such delivery. They enrolled 1,006 women who delivered liveborn singleton infant less than 28 weeks' at 14 centers United States between 2002 and 2004. Each was classified by presentation: labor (40%), prelabor premature rupture membranes (23%), preeclampsia (18%), placental abruption...
<h3>Importance</h3> Between 0.3% and 0.5% of all pregnancies occur among women with epilepsy. Evidence suggests an increase in perinatal morbidity mortality However, these risks have not been quantified large population-based samples. <h3>Objective</h3> To report on the risk for death adverse outcomes at time delivery epilepsy United States. <h3>Design, Setting, Participants</h3> Retrospective cohort study pregnant identified through hospitalization records from 2007-2011 Nationwide...
Phthalate exposure occurs readily in the environment and has been associated with an array of health end points, including adverse birth outcomes. Some these may be mediated by oxidative stress, a proposed mechanism for phthalate action.In present study, we explored associations between metabolites biomarkers stress measured urine samples from multiple time points during pregnancy.Women were participants nested case-control study preterm (n = 130 cases, n 352 controls). Each was recruited...
Low vitamin D status in pregnancy was proposed as a risk factor of preeclampsia.We assessed the effect supplementation (4,400 vs. 400 IU/day), initiated early (10-18 weeks), on development preeclampsia. The effects serum (25-hydroxyvitamin [25OHD]) levels preeclampsia incidence at trial entry and third trimester (32-38 weeks) were studied. We also conducted nested case-control study 157 women to investigate peripheral blood D-associated gene expression profiles 10 18 weeks 47 participants...
Abstract Maternal morbidity and mortality continue to rise, pre-eclampsia is a major driver of this burden 1 . Yet the ability assess underlying pathophysiology before clinical presentation enable identification pregnancies at risk remains elusive. Here we demonstrate plasma cell-free RNA (cfRNA) reveal patterns normal pregnancy progression determine developing months presentation. Our results centre on comprehensive transcriptome data from eight independent prospectively collected cohorts...
We sought to validate several clinical risk factors previously described for preeclampsia in a large contemporary multicenter prospective cohort.We enrolled women from three sites before 15 weeks of gestation. Demographic and were collected through standardized chart review. The main outcome was diagnosed using the American College Obstetricians Gynecologists definitions 2002. Multivariable logistic regression used control confounders.Two thousand six hundred thirty-seven are included this...
Recent studies have revealed increased morbidity and mortality rates in term neonates without birth defects who were delivered before 39 weeks of completed gestation. We sought to determine if a similar association exists between gestational age at delivery adverse outcomes with critical congenital heart disease, particular interest those born 37 38 weeks' gestation.We studied 971 consecutive had disease known admitted our cardiac ICU from 2002 through 2008. Gestational was stratified into 5...
Problem Previous studies have investigated the utility of inflammation markers as predictors preterm birth, but none compared trends in levels between uncomplicated and pregnancy. Method study We explored longitudinal changes plasma cytokines, including IL ‐1β, ‐6, ‐10, TNF ‐α, well C‐reactive protein pregnant women from a nested case–control study. Results ‐6 was associated with increased odds spontaneous defined by presentation labor and/or premature rupture membranes. Associations were...
Environmental exposure to polycyclic aromatic hydrocarbons (PAHs) is prevalent and may adversely impact pregnancy development of the fetus. The purpose this exploratory study was examine urinary PAH metabolites in potential association with mediators these outcomes. To do so, we measured a panel 12 inflammatory, angiogenic, oxidative stress biomarkers plasma or urine from women their third trimester (n = 200). Urinary were highly detectable (>88%) population, most higher who had lower...
Preeclampsia represents a major cause of maternal mortality and morbidity worldwide. Although it is known that the placenta plays central role in development preeclampsia, investigation into contribution environmental toxicants to risk preeclampsia has been sparse.In present study we examined relationship between longitudinally measured urinary BPA phthalate metabolite concentrations during gestation preeclampsia.A nested case-control preterm birth was performed 2011 from women enrolled...
Mediation analysis is useful for understanding mechanisms and has been used minimally in the study of environment disease.We examined mediation association between phthalate exposure during pregnancy preterm birth by oxidative stress.This nested case-control (n = 130 cases, 352 controls) included women who delivered Boston, Massachusestts, from 2006 through 2008. Phthalate metabolites 8-isoprostane, an stress biomarker, were measured urine three visits pregnancy. We applied four...
Preterm birth is a global public health issue and rates in Puerto Rico are consistently among the highest USA. Exposures to environmental contaminants might be contributing factor. In preliminary analysis from Testsite for Exploring Contamination Threats (PROTECT) cohort (n = 1090), we investigated association between urinary phthalate metabolite concentrations measured at three study visits (targeted 20, 24, 28 weeks of gestation) individually averaged over pregnancy with gestational age...