A5047822007- Congenital Heart Disease Studies
- Appendicitis Diagnosis and Management
- Emergency and Acute Care Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Pediatric Urology and Nephrology Studies
- Congenital Diaphragmatic Hernia Studies
- Hernia repair and management
- Central Venous Catheters and Hemodialysis
- Healthcare Policy and Management
- Intestinal Malrotation and Obstruction Disorders
- Coronary Artery Anomalies
- Surgical site infection prevention
- Mechanical Circulatory Support Devices
- Neonatal Respiratory Health Research
- Transplantation: Methods and Outcomes
- Ultrasound in Clinical Applications
- Cardiovascular Issues in Pregnancy
- Organ Transplantation Techniques and Outcomes
- Pulmonary Hypertension Research and Treatments
- Renal Transplantation Outcomes and Treatments
- Radiation Dose and Imaging
- Cardiac Valve Diseases and Treatments
- Urological Disorders and Treatments
- Respiratory Support and Mechanisms
- Cardiovascular Syncope and Autonomic Disorders
National Patient Safety Foundation
2014-2025
Boston Children's Hospital
2016-2025
Harvard University
2015-2025
Servicio Canario de la Salud
2023
Boston Children's Museum
2010-2022
Systems Analytics (United States)
2022
Beth Israel Deaconess Medical Center
2019
Brigham and Women's Hospital
2019
Boston Medical Center
2019
Quality Research
2014-2017
The aim of this study was to determine the influence two key scaffold design parameters, void fraction (VF) and pore size, on attachment, growth, extracellular matrix deposition by several cell types. Disc-shaped, porous, poly(-lactic acid) (L-PLA) scaffolds were manufactured TheriForm solid free-form fabrication process generate with VF (75% 90%) four size distributions (< 38, 38-63, 63-106, 106-150 microm). Microcomputed tomography analysis revealed that average generally larger than NaCl...
The human heart is believed to grow by enlargement but not proliferation of cardiomyocytes (heart muscle cells) during postnatal development. However, recent studies have shown that cardiomyocyte a mechanism cardiac growth and regeneration in animals. Combined with evidence for turnover adult humans, this suggests may play an unrecognized role the period developmental between birth adolescence. We tested hypothesis examining cellular mechanisms left ventricle on set healthy hearts from...
Abstract Purpose To determine the inter‐ and intraobserver reproducibility of cardiac magnetic resonance (CMR)‐derived measurements right ventricular (RV) mass, volume, function in patients with normal dilated ventricles. Materials Methods CMR studies 60 three groups were studied: a RV group ( N = 20) two dilation—atrial septal defect (ASD) repaired tetralogy Fallot (TOF) 20). Two independent observers analyzed each study on separate occasions. Inter‐ biventricular ejection fraction (EF),...
Anecdotal and lay press reports suggest that the incidence of pediatric urolithiasis is increasing but reliable data are lacking. The objective this study was to examine trends in epidemiology at hospitals nationwide.The Pediatric Health Information System database a national covering 42 freestanding United States captures inpatient admissions, emergency department outpatient surgery visits. We searched identify children (18 years old or younger) treated for between 1999 2008. Patients with...
OBJECTIVE. Our goal was to determine whether an intervention involving staff education, increased awareness, and practice changes would decrease central line–associated bloodstream infection rates in a pediatric cardiac ICU. METHODS. A retrospective, interventional study using interrupted time-series design conducted compare during 3 time periods for all patients admitted our ICU between April 1, 2004, December 31, 2006. During the preintervention period (April 2004 2004), committee convened...
The objectives are to describe health outcomes and hospital resource use of children after tracheotomy identify patient characteristics that correlate with use.A retrospective analysis 917 aged 0 18 years undergoing from 36 children's hospitals in 2002 follow-up through 2007. Children were identified ICD-9-CM procedure codes. Comorbid conditions (neurologic impairment [NI], chronic lung disease, upper airway anomaly, prematurity, trauma) diagnostic Patient compared in-hospital mortality,...
In the Fluid and Catheter Treatment Trial (NCT00281268), adults with acute lung injury randomized to a conservative vs. liberal fluid management protocol had increased days alive free of mechanical ventilator support (ventilator-free days). Recruiting sufficient children into pediatric trial is challenging. A Bayesian statistical approach relies on adult for priori effect estimate, requiring fewer patients. Preparing mirroring Trial, we aimed to: 1) identify an inverse association between...
Recent studies have revealed increased morbidity and mortality rates in term neonates without birth defects who were delivered before 39 weeks of completed gestation. We sought to determine if a similar association exists between gestational age at delivery adverse outcomes with critical congenital heart disease, particular interest those born 37 38 weeks' gestation.We studied 971 consecutive had disease known admitted our cardiac ICU from 2002 through 2008. Gestational was stratified into 5...
Jay Berry and colleagues report findings from an analysis of hospitalization data in the US, examining proportion inpatient resources attributable to care for children with neurological impairment.
<h3>Objective</h3> The Fontan operation is a staged palliation for complex congenital heart disease and single ventricle physiology. Perioperative survivors of the experience long-term cardiac complications, including death. Liver renal dysfunction are reported in these patients have direct effect on morbidity mortality. This study aims to investigate whether Model End-stage Disease eXcluding INR score (function creatinine total bilirubin, MELD-XI) predicts risk mortality or transplantation...
We determined the resolution rate of vesicoureteral reflux and factors that influence it to formulate nomograms predict probability annual for individual cases reflux.We studied 2,462 children with primary diagnosed between 1998 2006. Cox proportional hazards regression was used model time as a function statistically significant demographic clinical variables. The resulting construct predicting cumulative resolution.Multivariate analysis showed all unilateral resolved earlier than female...
The objective of this study was to examine the relationship between exercise test data and mortality in patients who have had Fontan procedure.The designed as a retrospective cohort study.The set tertiary care center.All participants were ≥16 years old cardiopulmonary tests at our institution November 2002 March 2010. first with adequate effort during period retained for analysis. We enrolled 146 median age 21.5 (16.0-51.6); 15.8 (1.2-29.9) after surgery.The outcome measures (peak oxygen...
Children of parents expressing limited comfort with English (LCE) or proficiency may be at increased risk adverse events (harms due to medical care). No prior studies have examined, in a multicenter fashion, the association between language and systematically, actively collected that include family safety reporting.To examine parent LCE cohort hospitalized children.This prospective study was conducted from December 2014 January 2017, concurrent data collection Patient Family Centered I-PASS...
A foam suspension containing oxygen gas–filled microparticles can deliver life-sustaining during a 15-min period of complete asphyxia.
The pathophysiology of perinatal brain injury is multifactorial and involves hypoxia-ischemia (HI) inflammation. N-methyl-d-aspartate receptors (NMDAR) are present on neurons glia in immature rodents, NMDAR antagonists protective HI models. To enhance clinical translation rodent data, we examined protein expression 6 subunits postmortem human brains without from 20 postconceptional weeks through adulthood cases periventricular leukomalacia (PVL). We hypothesized that the developing...
BACKGROUND: The national incidence of neonatal abstinence syndrome (NAS) has increased with the opioid epidemic in United States. impact pharmacologic treatment on hospital use is not well established. We examined recent population neonates NAS admitted to pediatric hospitals, variation treatment, and effect resource during hospitalization, including length stay (LOS), readmission, cost-of-living adjusted costs. METHODS: included inpatients discharged between January 2013 March 2016 from...
We sought to identify risk factors for central line-associated bloodstream infection (CLABSI) describe children who might benefit from adjunctive interventions.Case-control study of admitted the medical-surgical intensive care unit (ICU) or cardiac ICU January 1, 2004, through December 31, 2007.Children's Hospital Boston is a freestanding, 396-bed quaternary pediatric hospital with 29-bed and 24-bed ICU.Case patients were CLABSI identified by means prospective surveillance. Control subjects...
<h3>Objectives</h3> To identify children at risk for in-hospital mortality following tracheotomy. <h3>Design</h3> Retrospective cohort study. <h3>Setting</h3> 25 746 876 US hospitalisations within the Kids9 Inpatient Database 1997, 2000, 2003 and 2006. <h3>Participants</h3> 18 806 of ages 0–18 years undergoing tracheotomy, identified from ICD-9-CM tracheotomy procedure codes. <h3>Main outcome measure</h3> Mortality during initial hospitalisation when was performed in relation to patient...
Objective: To identify risk factors for central line-associated bloodstream infection (BSI) in patients receiving care a pediatric cardiac intensive unit. Design: Matched case-control study. Setting: CICU at Children's Hospital Boston. Patients: Central BSI cases were identified between April 2004 and December 2006. We two randomly selected control who had vascular catheter admitted within 7 days of each index case. Measurements Main Results: Univariate multivariate conditional logistic...
Quantitative assessment of ventricular volumes and mass in pediatric patients with single-ventricle physiology would aid clinical management, but it is difficult to obtain 2-dimensional echocardiography. The purpose the present study was compare matrix-array 3-dimensional echocardiography (3DE) measurements volumes, mass, ejection fraction those measured by cardiac magnetic resonance (CMR) young patients.Twenty-nine (median age, 7 months) a functional single ventricle undergoing CMR under...
Background— A change in allocation algorithm July 2006 allowed broader regional sharing of donor hearts the United States (US). We assessed if has been associated with a decline wait list mortality US. Methods and Results— compared baseline characteristics outcomes patients ≥18 years old listed for primary heart transplant US before (July 1, 2004–July 11, 2006, Era1) after 12, 2006–June 30, 2009, Era 2) algorithm. Of 11 864 study, 4503 were during 1 7361 2. Patients 2 more likely to be...