A5083497987- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Animal Virus Infections Studies
- Congenital Diaphragmatic Hernia Studies
- Cardiovascular Issues in Pregnancy
- Heart Failure Treatment and Management
- Viral gastroenteritis research and epidemiology
- Healthcare Policy and Management
- Coronary Artery Anomalies
- Mechanical Circulatory Support Devices
- Teaching and Learning Programming
- Tracheal and airway disorders
- Virus-based gene therapy research
- Innovations in Medical Education
- Cardiac pacing and defibrillation studies
- Influenza Virus Research Studies
- Vascular anomalies and interventions
- Health and Medical Research Impacts
- Neuroendocrine regulation and behavior
- Respiratory viral infections research
Boston Children's Hospital
2015-2024
Harvard University
2015-2024
Boston Children's Museum
2012-2023
Fundação Oswaldo Cruz
2022
The University of Melbourne
2020
Austin Health
2020
Peninsula Health
2020
Eastern Health
2020
Monash Health
2020
Monash University
2020
Adverse neurodevelopmental outcome is an important source of morbidity in children with congenital heart disease (CHD). A significant proportion newborns complex CHD have abnormalities brain size, structure, or function, which suggests that antenatal factors may contribute to childhood morbidity.Brain volume and metabolism were compared prospectively between 55 fetuses 50 normal the use 3-dimensinal volumetric magnetic resonance imaging proton spectroscopy. Fetal intracranial cavity volume,...
Oxidative stress may play a role in the pathophysiology of diabetes and cardiovascular disease, but little is known about antioxidant status among individuals with metabolic syndrome who are at high risk for developing these conditions. Using data from Third National Health Nutrition Examination Survey (1988-1994), we compared circulating concentrations vitamins A, C, E; retinyl esters; five carotenoids; selenium 8,808 U.S. adults aged > or = 20 years without syndrome. After adjusting age,...
Aortic stenosis in the midgestation fetus with a normal-sized or dilated left ventricle predictably progresses to hypoplastic heart syndrome when associated certain physiological findings. Prenatal balloon aortic valvuloplasty may improve growth and function, possibly preventing evolution syndrome.Between March 2000 October 2008, 70 fetuses underwent attempted for critical evolving syndrome. We analyzed this experience determine factors procedural postnatal outcome. The median gestational...
Neurologic impairment is a major complication of complex congenital heart disease (CHD). A growing body evidence suggests that neurologic dysfunction may be present in significant proportion this high-risk population the early newborn period prior to surgical interventions. We recently provided first brain growth fetuses with CHD has its origins utero. Here, we extend these observations by characterizing global and regional development hypoplastic left syndrome (HLHS), one most severe forms...
Clinical evidence supports the use of cardiac resynchronization therapy (CRT) in adults with heart failure, but experience pediatrics and congenital disease (CHD) is limited terms patient numbers follow-up. We sought to determine functional assessment clinical outcomes pediatric CHD CRT patients followed uniformly at one institution.Retrospective review 60 consecutive who underwent between 2002 2007.At implantation, median age was 15.0 years (5 months 47 years). Overall, 46 had (77%) 14...
Seventy employees at four job levels in a large corporation completed questionnaire on their office environments six months before and weeks after moving from conventional to an "open-plan" office. Secretarial supervisors (job level 1) moved freestanding desks partly enclosed workspaces. Staff specialists 11) left double offices for individual, doorless enclosures. Managerial Ill IV) walled large, Neither satisfaction with commu nications nor perceptions of noise changed relocation, but...
Recent studies have revealed increased morbidity and mortality rates in term neonates without birth defects who were delivered before 39 weeks of completed gestation. We sought to determine if a similar association exists between gestational age at delivery adverse outcomes with critical congenital heart disease, particular interest those born 37 38 weeks' gestation.We studied 971 consecutive had disease known admitted our cardiac ICU from 2002 through 2008. Gestational was stratified into 5...
When young suckle, they are rewarded intermittently with a let-down of milk that results from reflex secretion the hormone oxytocin; without oxytocin, newly born will die unless fostered. Oxytocin is made by magnocellular hypothalamic neurons, and secreted their nerve endings in pituitary response to action potentials (spikes) generated cell bodies which propagated down axons endings. Normally, oxytocin cells discharge asynchronously at 1–3 spikes/s, but during suckling, every 5 min or so,...
Routine preoperative catheterization is standard practice in patients with single-ventricle physiology before bidirectional Glenn anastomosis. Because invasive and exposes to ionizing radiation, cardiac magnetic resonance (CMR) may be a safe effective alternative.We conducted prospective, randomized, single-center clinical trial comparing CMR considered for operation from February 2003 June 2006. End points were frequency of adverse events the evaluation composite score clinically successful...
Abstract We use administrative data from the Internal Revenue Service to examine long-term impacts of childhood Medicaid eligibility expansions on outcomes in adulthood at each age 19 28. Greater increases college enrolment and decreases fertility, especially through 21. Starting 23, females have higher contemporaneous wage income, although male are imprecise. Together, both genders lower mortality. These adults collect less earned income tax credit pay more taxes. Cumulatively ages 28, a 3%...
Abstract Aims The Fontan operation has resulted in improved survival patients with single‐ventricle congenital heart disease. As a result, there is growing population of teenagers and adults circulation. Many co‐morbidities have been increasingly recognized this due to the unique features Standardization how co‐morbid conditions are defined will help facilitate understanding, consistency interpretability research clinical experience. Unifying common language usage critical precursor step for...
The last decade witnessed a significant increase in epidemic activity of human enterovirus 71 (EV71) the Western Pacific Region (WPR). In most European countries, this risk is unrecognized despite occasional cases severe disease and two outbreaks Eastern Europe 30 years ago. study we report first examination molecular epidemiology EV71 United Kingdom from 1998 to 2006. Genomic regions encoding 1D coat protein (VP1) 3D polymerase (Pol) 32 isolates associated with neurological or cutaneous...
Congenital heart defects (CHD), as the most common congenital anomaly, have been reported to be frequently associated with pathogenic copy number variants (CNVs). Currently, patients CHD are routinely offered chromosomal microarray (CMA) testing, but diagnostic yield of CMA on has not extensively evaluated based a large patient cohort. In this study, we retrospectively assessed detected CNVs in total 514 cases (a 422-case clinical cohort from Boston Children's Hospital (BCH) and 92-case...
Background Interstage mortality ( IM ) remains significant after stage 1 palliation (S1P) for single‐ventricle heart disease SVD ), with many deaths sudden and unexpected. We sought to determine whether digoxin use post‐S1P is associated reduced , utilizing the multicenter database of National Pediatric Cardiology Quality Improvement Collaborative NPCQIC ). Methods Results From June 2008 July 2013, 816 infants discharged S1P from 50 surgical sites completed interstage II palliation,...
Abstract Optimising short- and long-term outcomes for children patients with CHD depends on continued scientific discovery translation to clinical improvements in a coordinated effort by multiple stakeholders. Several challenges remain clinicians, researchers, administrators, patients, families seeking continuous advancements the field. We describe new integrated research improvement network – Cardiac Networks United that seeks build upon experience success achieved to-date create...
As of 2018, 118 194 WHO Member States reported the presence an influenza vaccination policy. Although policies do not guarantee equitable access or ensure coverage, they are critical to establishing a coordinated program, which can reduce morbidity and mortality associated with yearly influenza, especially in high-risk groups. Established programs also provide good foundation for pandemic preparedness response.We utilized EXCEL STATA evaluate changes national seasonal on WHO/UNICEF Joint...
This article evaluates the pediatric cardiology (PC) workforce and forecasts its future supply. Produced as part of a supplement in Pediatrics, this effort represents collaboration among American Board Pediatrics Foundation, University North Carolina at Chapel Hill’s Health Workforce Research Center, Strategic Modeling Analysis Ltd., members subspecialty community. PC is complex including care from fetal life through adulthood practice settings that range outpatient clinic to procedural...
A reverse transcription-polymerase chain reaction (RT-PCR) amplification procedure was developed for the detection of Norwalk-like viruses in fecal specimens. Ninety-nine specimens collected United Kingdom and containing small round-structured virus particles as determined by electron microscopy were tested. They came from 50 outbreaks 16 sporadic cases viral gastroenteritis. RT-PCR products appropriate size Norwalk RNA detected 15 three outbreaks, suggesting that closely related to have not...
Objective To evaluate temporal trends in the prenatal diagnosis of transposition great arteries with intact ventricular septum (TGA/IVS) and its impact on neonatal morbidity mortality. Methods We included this study cohort newborns TGA/IVS who were referred for surgical management to our center over a 20-year period (1992–2011). The was divided into five 4-year periods primary outcome rate diagnosis. Secondary outcomes preoperative status perioperative survival. Results Of 340 patients...