A5039085427- Neonatal and fetal brain pathology
- Fetal and Pediatric Neurological Disorders
- Congenital Heart Disease Studies
- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Prenatal Screening and Diagnostics
- Neuroscience of respiration and sleep
- Birth, Development, and Health
- Coronary Artery Anomalies
- Cardiovascular Issues in Pregnancy
- Anesthesia and Neurotoxicity Research
- COVID-19 Impact on Reproduction
- Prenatal Substance Exposure Effects
- Mechanical Circulatory Support Devices
- Domain Adaptation and Few-Shot Learning
- Aortic Disease and Treatment Approaches
- EEG and Brain-Computer Interfaces
- Traumatic Brain Injury and Neurovascular Disturbances
- Pediatric Pain Management Techniques
- Infant Nutrition and Health
George Washington University
2016-2025
Children's National
2016-2025
Children's Hospital of Philadelphia
2024
Health and Human Development (2HD) Research Network
2024
University of Alabama
2024
Case Western Reserve University
2024
RTI International
2024
Cincinnati Children's Hospital Medical Center
2023-2024
Emory University
2024
Tufts University
2024
Adverse neurodevelopmental outcome is an important source of morbidity in children with congenital heart disease (CHD). A significant proportion newborns complex CHD have abnormalities brain size, structure, or function, which suggests that antenatal factors may contribute to childhood morbidity.Brain volume and metabolism were compared prospectively between 55 fetuses 50 normal the use 3-dimensinal volumetric magnetic resonance imaging proton spectroscopy. Fetal intracranial cavity volume,...
OBJECTIVE. The survival of very low birth weight infants has increased markedly in recent years. Unfortunately, the prevalence significant and lifelong motor, cognitive, behavioral dysfunction remained a major problem confronting these children. objective this study was to perform screening tests for early autistic features children with history identify risk factors associated positive result. METHODS. We studied 91 ex-preterm ≤ 1500 g at birth. Infants underwent conventional MRI studies...
Objective. Cognitive impairments and academic failure are commonly reported in survivors of preterm birth. Recent studies suggest an important role for the cerebellum development cognitive social functions. The objective this study was to examine impact prematurity itself, as well prematurity-related brain injuries, on early postnatal cerebellar growth with quantitative MRI. Methods. Advanced 3-dimensional volumetric MRI performed volumes were obtained by manual outlining (<37 weeks)...
Abstract Longitudinal characterization of early brain growth in-utero has been limited by a number challenges in fetal imaging, the rapid change size, shape and volume developing brain, consequent lack suitable algorithms for image analysis. There is need an improved digital atlas spatiotemporal maturation extending over key developmental periods. We have developed algorithm construction unbiased four-dimensional integrating symmetric diffeomorphic deformable registration space with kernel...
Neurologic impairment is a major complication of complex congenital heart disease (CHD). A growing body evidence suggests that neurologic dysfunction may be present in significant proportion this high-risk population the early newborn period prior to surgical interventions. We recently provided first brain growth fetuses with CHD has its origins utero. Here, we extend these observations by characterizing global and regional development hypoplastic left syndrome (HLHS), one most severe forms...
Prenatal maternal stress is increasingly associated with adverse outcomes in pregnant women and their offspring. However, the association between human fetal brain growth metabolism unknown.To identify prenatal psychological distress growth, cortical maturation, biochemical development using advanced 3-dimensional volumetric magnetic resonance imaging (MRI) proton spectroscopy (1H-MRS).This cohort study prospectively recruited from low-risk obstetric clinics Washington, DC, January 1, 2016,...
Controversy exists regarding the integrity of nervous system in newborn with a congenital heart defect who must undergo corrective or palliative open surgery. Neurodevelopmental sequelae have been primarily attributed to surgical procedures without standardized evaluation preoperative neurologic status.Objective. To determine whether newborns defects demonstrate abnormalities neurobehavioral status before surgery.Study Design. In this prospective study, neonatal assessment and examination...
To determine the efficacy of sucrose analgesia for procedural pain during first week life in preterm neonates neonatal intensive care units on enhancing later clinical outcomes.A total 107 who were born at <31 weeks' postconceptional age (PCA) entered this double-blind, randomized, controlled trial within 48 hours birth 3 level III university-affiliated Canada, and 103 completed study. Sucrose (0.1 mL 24%) or sterile water was administered orally up to times, 2 minutes apart, every invasive...
Cerebellar hemorrhage (CBH) in premature infants is increasingly diagnosed secondary to improved neuroimaging techniques and survival of very small preterm infants. Information limited, however, on the incidence, topography, risk factors for CBH infant. Objectives. To define incidence by neonatal cranial ultrasound (US), describe sonographic features CBH, identify maternal perinatal associated with this lesion. Methods. A systematic electronic database search identified born 1998–2002 US...
Advanced neuroimaging techniques have brought increasing recognition of cerebellar injury among premature infants. The developmental relationship between early brain and effects on the cerebrum cerebellum remains unclear.To examine whether cerebral parenchymal lesions preterm infants are associated with subsequent decreases in volume and, conversely, primary is decreased volumes, advanced, 3-dimensional, volumetric MRI at term gestational age equivalent.Total volumes gray myelinated white...
Cerebellar injury is an important complication of preterm birth with far-reaching neuropsychiatric sequelae. We have previously shown a significant association between isolated to the premature cerebellum and subsequent impairment regional volumetric growth in contralateral cerebrum. In current study, we examine relationship these remote impairments cerebral domain-specific functional deficits children. 40 ex-preterm infants cerebellar injury, performed neurodevelopmental evaluations...
OBJECTIVES. Periventricular hemorrhagic infarction is a serious complication of germinal matrix-intraventricular hemorrhage in premature infants. Our objective was to determine the neurodevelopmental and adaptive outcomes periventricular survivors identify early cranial ultrasound predictors adverse outcome. METHODS. We retrospectively evaluated all ultrasounds 30 infants with assigned ultrasound–based severity score (range: 0–3) on basis whether (1) involved ≥2 territories, (2) bilateral,...
OBJECTIVES: Cerebral pressure passivity is common in sick premature infants and may predispose to germinal matrix/intraventricular hemorrhage (GM/IVH), a lesion with potentially serious consequences. We studied the association between magnitude of cerebral GM/IVH. PATIENTS AND METHODS: enrolled &lt;32 weeks' gestational age indwelling mean arterial (MAP) monitoring excluded known congenital syndromes or antenatal brain injury. recorded continuous MAP near-infrared spectroscopy hemoglobin...
BACKGROUND AND OBJECTIVES:. Compared with term infants, preterm infants have impaired brain development at term-equivalent age, even in the absence of structural injury. However, details regarding onset and progression over third trimester are unknown. Our primary objective was to compare third-trimester volumes growth trajectories ex utero without injury healthy fetuses. As a secondary objective, we examined risk factors associated postconception.METHODS:. Preterm born before 32 weeks...
This study characterizes global and hemispheric brain growth in healthy human fetuses during the second half of pregnancy using three-dimensional MRI techniques. We studied 166 that underwent between 18 39 completed weeks gestation. created high-resolution reconstructions calculated volumes for left right cortical gray matter (CGM), fetal white (FWM), deep subcortical structures (DSS), cerebellum. rate each tissue class according to gestational age described patterns growth. Each region...