A5029831731- Neonatal and fetal brain pathology
- Congenital Heart Disease Studies
- Fetal and Pediatric Neurological Disorders
- Advanced Neuroimaging Techniques and Applications
- Coronary Artery Anomalies
- Infant Development and Preterm Care
- Domain Adaptation and Few-Shot Learning
- Neonatal Respiratory Health Research
- Functional Brain Connectivity Studies
- Birth, Development, and Health
- Congenital heart defects research
- Prenatal Screening and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiovascular Issues in Pregnancy
- Health, Environment, Cognitive Aging
- Advanced MRI Techniques and Applications
- Pregnancy and preeclampsia studies
- Renal and Vascular Pathologies
- Aortic Disease and Treatment Approaches
- Child and Adolescent Psychosocial and Emotional Development
- Maternal Mental Health During Pregnancy and Postpartum
- Medical Imaging Techniques and Applications
- Child Abuse and Trauma
- MRI in cancer diagnosis
- Congenital Diaphragmatic Hernia Studies
Washington University in St. Louis
2013-2025
Boston Children's Museum
2023
Boston Children's Hospital
2023
University of Ottawa
2022
The University of Queensland
2022
Mater Research
2022
University of Cambridge
2022
Isala
2022
Leiden University Medical Center
2022
University Children's Hospital Tübingen
2019
Abstract Longitudinal characterization of early brain growth in-utero has been limited by a number challenges in fetal imaging, the rapid change size, shape and volume developing brain, consequent lack suitable algorithms for image analysis. There is need an improved digital atlas spatiotemporal maturation extending over key developmental periods. We have developed algorithm construction unbiased four-dimensional integrating symmetric diffeomorphic deformable registration space with kernel...
Neurodevelopmental impairment is common in children with congenital heart disease (CHD), but postnatal variables explain only 30% of the variance outcomes. To explore whether antecedents for neurodevelopmental disabilities might begin utero, we analyzed fetal brain volume predicted subsequent outcome CHD.
Significance The human brain exhibits complex folding patterns that emerge during the third trimester of fetal development. Minor folds are quasi-randomly shaped and distributed. Major folds, in contrast, more conserved form important landmarks. Disruption cortical is associated with devastating disorders cognition emotion. Despite decades study, processes produce normal abnormal remain unresolved, although relatively rapid tangential expansion cortex has emerged as a driving factor....
Congenital heart disease (CHD) is associated with abnormal brain development in utero. We applied innovative fetal magnetic resonance imaging (MRI) techniques to determine whether reduced cerebral substrate delivery impacts the globally, or a region-specific pattern. Our novel design included two control groups, one and other without family history of CHD, explore contribution shared genes and/or environment development.From 2014 2018, we enrolled 179 pregnant women into 4 groups: "HLHS/TGA"...
Neurodevelopmental impairment is a common and important long-term morbidity among infants with congenital heart disease (CHD). More than half of those complex CHD will demonstrate some form neurodevelopmental, neurocognitive, and/or psychosocial dysfunction requiring specialized care impacting quality life. Preventing brain injury treating neurologic sequelae in this high-risk clinical population imperative for improving neurodevelopmental outcomes. Thus, cardiac now at the forefront...
Abstract Fetuses with congenital heart disease (CHD) have third trimester alterations in cortical development on brain magnetic resonance imaging (MRI). However, the intersulcal relationships contributing to global sulcal pattern remain unknown. This study applied a novel method for examining geometric and topological between sulci fetal MRIs from 21–30 gestational weeks CHD fetuses (n = 19) typically developing (TD) 17). Sulcal similarity index (SI) template was determined position, area,...
Fetal cortical plate segmentation is essential in quantitative analysis of fetal brain maturation and folding. Manual the plate, or manual refinement automatic segmentations tedious time-consuming. Automatic on other hand, challenged by relatively low resolution reconstructed MRI scans compared to thin structure partial voluming, wide range variations morphology as matures during gestation. To reduce burden segmentations, we have developed a new powerful deep learning method. Our method...
Abstract The third trimester of pregnancy is a period rapid development fiber bundles in the fetal white matter. Using recently developed motion‐tracked slice‐to‐volume registration (MT‐SVR) method, we aimed to quantify tract‐specific developmental changes apparent diffusion coefficient (ADC), fractional anisotropy (FA), and volume healthy fetuses. To this end, reconstructed tensor images from motion corrected magnetic resonance imaging data. With an approved protocol, MRI exams were...
BACKGROUND AND OBJECTIVES Neurodevelopmental evaluation of toddlers with complex congenital heart disease is recommended but reported frequency low. Data on barriers to attending neurodevelopmental follow-up are limited. This study aims estimate the attendance rate for a toddler in contemporary multicenter cohort and assess patient center level factors associated this evaluation. METHODS retrospective children born between September 2017 2018 who underwent cardiopulmonary bypass their first...
Altered brain development is a common feature of the neurological sequelae complex congenital heart disease (CHD). These alterations include abnormalities in size and growth that begin prenatally persist postnatally. However, longitudinal trajectory changes volume from prenatal to postnatal environment have not been investigated. We aimed evaluate cohort patients with CHD (n = 16) healthy controls 15) test hypothesis would smaller total (TBV) prenatally, which become increasingly prominent...
Fetuses with isolated agenesis of the corpus callosum (ACC) are associated a broad spectrum neurodevelopmental disability that cannot be specifically predicted in prenatal neuroimaging. We hypothesized ACC may aberrant cortical folding. In this study, we determined altered patterning early primary sulci development fetuses using novel quantitative sulcal pattern analysis which measures deviations regional features (position, depth, and area) their intersulcal relationships 7 (27.1 ± 3.8...
Abstract Background Neurodevelopmental impairments are common in children with congenital heart disease. The Cardiac Outcome Collaborative and Pediatric Critical Care Consortium registry linkage allows for the analysis of associations between neurodevelopmental, medical, sociodemographic variables a large contemporary cohort. Methods Children disease who required surgery cardiopulmonary bypass at <12 months age completed neurodevelopmental assessment 11-30 from 2019-2022 were included....
<h3>BACKGROUND AND PURPOSE:</h3> Aberrant gyral folding is a key feature in the diagnosis of many cerebral malformations. However, fetal life, it particularly challenging to confidently diagnose aberrant because rapid spatiotemporal changes development. Currently, there no resource measure how an individual brain compares with normal variations. In this study, we assessed potential for automatic analysis early sulcal patterns detect brains abnormalities. <h3>MATERIALS METHODS:</h3> Triplane...
<h3>BACKGROUND AND PURPOSE:</h3> Brain MRI of newborns with congenital heart disease show signs immaturity relative to healthy controls. Our aim was determine whether the semiquantitative fetal total maturation score can detect abnormalities in brain fetuses second and third trimesters. <h3>MATERIALS METHODS:</h3> We analyzed data from a prospective study without who underwent MR imaging at 25–35 weeks' gestation. Two independent neuroradiologists blinded clinical reviewed scored all images...
Abstract Sulcal pits are thought to represent the first cortical folds of primary sulci during neurodevelopment. The uniform spatial distribution sulcal across individuals is hypothesized be predetermined by a human-specific protomap which related functional localization under genetic controls in early fetal life. Thus, it important characterize temporal and patterns brain that would provide additional information development human crucial insights into abnormal maturation. In this paper, we...