A5083276328- Congenital Heart Disease Studies
- Coronary Artery Anomalies
- Infant Development and Preterm Care
- Cardiac Arrhythmias and Treatments
- Functional Brain Connectivity Studies
- Cardiovascular Conditions and Treatments
- Congenital heart defects research
- Metabolism and Genetic Disorders
- Amino Acid Enzymes and Metabolism
- Telemedicine and Telehealth Implementation
- Neural and Behavioral Psychology Studies
- Adolescent and Pediatric Healthcare
- Diet and metabolism studies
- Neonatal and fetal brain pathology
- Cardiac Arrest and Resuscitation
- Electroconvulsive Therapy Studies
- Cardiac Structural Anomalies and Repair
- Advanced Neuroimaging Techniques and Applications
- Autoimmune and Inflammatory Disorders
- Renal and Vascular Pathologies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiovascular Issues in Pregnancy
- Mitochondrial Function and Pathology
- Diverticular Disease and Complications
- Cardiovascular Function and Risk Factors
George Washington University
2014-2023
Children's National
2014-2022
George Washington University Hospital
2020
Children's Healthcare of Atlanta
2014
Hospital for Sick Children
2014
C. S. Mott Children's Hospital
2014
Children's Hospital of Wisconsin
2014
Alfred I. duPont Hospital for Children
2014
Thomas Jefferson University
2014
Boston Children's Museum
2014
Abstract In 2012, the American Heart Association and Academy of Paediatrics released a scientific statement with guidelines for evaluation management neurodevelopmental needs children CHD. Decades outcome research now highlight range cognitive, learning, motor, psychosocial vulnerabilities affecting individuals CHD across lifespan. The number institutions Cardiac Neurodevelopmental Follow-Up Programmes services is growing worldwide. This manuscript provides an expanded set strategies...
Executive function, a set of cognitive skills important to social and academic outcomes, is specific area weakness in children with congenital heart disease (CHD). We evaluated the prevalence profile executive dysfunction heterogeneous sample school aged CHD, examined whether are receiving services support, identified risk factors for at age.Ninety-one patients completed questionnaires, including Behavior Rating Inventory Function (BRIEF) medical history questionnaire. An age- gender-...
BACKGROUND AND OBJECTIVES Neurodevelopmental evaluation of toddlers with complex congenital heart disease is recommended but reported frequency low. Data on barriers to attending neurodevelopmental follow-up are limited. This study aims estimate the attendance rate for a toddler in contemporary multicenter cohort and assess patient center level factors associated this evaluation. METHODS retrospective children born between September 2017 2018 who underwent cardiopulmonary bypass their first...
The Neurodevelopmental and Psychological Outcomes Working Group of the Cardiac Outcome Collaborative was formed in 2018 through support from an R13 grant National Heart, Lung, Blood Institute with goals identifying knowledge gaps regarding neurodevelopmental psychological outcomes individuals CHD investigations needed to advance science, policy, clinical care, patient/family outcomes. Accurate characterisation children will drive improvements patient family targeted intervention. Decades...
Abstract Background Neurodevelopmental impairments are common in children with congenital heart disease. The Cardiac Outcome Collaborative and Pediatric Critical Care Consortium registry linkage allows for the analysis of associations between neurodevelopmental, medical, sociodemographic variables a large contemporary cohort. Methods Children disease who required surgery cardiopulmonary bypass at <12 months age completed neurodevelopmental assessment 11-30 from 2019-2022 were included....
Abstract Over the last two decades, heart centres have developed strategies to meet neurodevelopmental needs of children with congenital disease. Since publication guidelines in 2012, cardiac follow-up programmes become more widespread. Local programmes, however, been independently widely varying environments. We sought characterise variation structure and personnel programmes. A 31-item survey was sent all member institutions Cardiac Neurodevelopmental Outcome Collaborative....
Youth with CHD are at greater risk for neurodevelopmental disorders compared to healthy controls. The aetiology is multi-factorial but includes medical and demographic factors. We sought characterise the prevalence of in patients CHD. Our population included 206 CHD, aged 3-21, who were referred neuropsychological evaluation. Neurodevelopmental diagnoses determined by a licensed psychologist. Rates national rates. Exploratory analyses (chi-square) examined which factors (i.e., cardiac...
Patients with germline mutations in the urea-cycle enzyme argininosuccinate lyase (ASL) are at risk for developing neurobehavioral and cognitive deficits. We find that ASL is prominently expressed nucleus locus coeruleus (LC), central source of norepinephrine. Using natural history data, we show individuals deficiency attention By generating LC-ASL-conditional knockout (cKO) mice, further demonstrate altered response to stressful stimuli increased seizure reactivity LC-ASL-cKO mice....
Abstract Compared to the general population, individuals with complex congenital heart disease are at increased risk for deficits in cognitive, neurodevelopmental, psychosocial, and physical functioning, resulting a diminished health-related quality of life. These have been well described over past 25 years, but significant gaps remain our understanding best practices improve neurodevelopmental psychosocial outcomes life paediatric disease. Innovative clinical, improvement, research...
In the wake of COVID-19 pandemic, psychologists were pushed to look beyond traditional in-person models neurodevelopmental assessment maintain continuity care. A wealth data demonstrates that telehealth is efficacious for pediatric behavioral intervention; however, best practices incorporating into are yet be developed. this topical review, we propose a conceptual model demonstrate how can incorporated various components assessment.Harnessing existing literature and expertise from...
COVID-19 has markedly impacted the provision of neurodevelopmental care. In response, Cardiac Neurodevelopmental Outcome Collaborative established a Task Force to assess telehealth practices cardiac programmes during COVID-19, including adaptation services, test protocols and interventions, perceived obstacles, disparities, successes, training needs.A 47-item online survey was sent 42 member sites across North America within 3-week timeframe (22 July 11 August 2020) collect cross-sectional...
Kabuki syndrome (KS) is a rare genetic involving dysmorphic facial features,and reports of intellectual disability (ID). We examined the developmental trajectory neuropsychological skills in child with KS (seen at ages 4, 6, 7, 9, and 11). Examination raw age-corrected standard scores suggests that language-based developed appropriately, but visually based slowed reached plateau. Executive dysfunction mood symptoms were also observed. While ID described as core feature KS,some patients may...
This report describes a patient who developed agitation, disorientation, visual hallucinations, inappropriate verbal outbursts, and impaired memory following resection of choroid plexus papilloma. No medical, neurologic, or metabolic disorders unre
Abstract Children with congenital heart disease (CHD) can face neurodevelopmental, psychological, and behavioural difficulties beginning in infancy continuing through adulthood. Despite overall improvements medical care a growing focus on neurodevelopmental screening evaluation recent years, disabilities, delays, deficits remain concern. The Cardiac Neurodevelopmental Outcome Collaborative was founded 2016 the goal of improving outcomes for individuals CHD pediatric disease. This paper...
C hildren with congenital heart dis- ease (CHD) are exceptionally resilient.After extensive surgeries and hospitalizations, they typically go on to live full, meaningful lives.However, some children CHD experience developmental learning differences benefit from extra help succeed in school, social relationships, future employment.