A5074089280- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Neurobiology of Language and Bilingualism
- EEG and Brain-Computer Interfaces
- Neonatal and fetal brain pathology
- Pharmacological Effects and Toxicity Studies
- Hemispheric Asymmetry in Neuroscience
- Attention Deficit Hyperactivity Disorder
- Language Development and Disorders
- Infant Development and Preterm Care
- Genetics and Neurodevelopmental Disorders
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Reading and Literacy Development
- Autism Spectrum Disorder Research
- Neural dynamics and brain function
- Congenital Heart Disease Studies
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Child and Adolescent Psychosocial and Emotional Development
- Children's Physical and Motor Development
- Neuroscience of respiration and sleep
- Neuroscience and Music Perception
George Washington University
2014-2025
Children's National
2016-2025
George Washington University Hospital
2022-2024
Cleveland Clinic Lerner College of Medicine
2023
Case Western Reserve University
2023
The Neurological Institute
2023
Cleveland Clinic
2023
Columbia University Irving Medical Center
2023
Jefferson Hospital for Neuroscience
2022-2023
Georgetown University
2007-2022
We have long known that language is lateralized to the left hemisphere (LH) in most neurologically healthy adults. In contrast, findings on lateralization of function during development are more complex. As adults, anatomical, electrophysiological, and neuroimaging studies infants children indicate LH for language. However, very young children, lesions either equally likely result deficits, suggesting distributed symmetrically early life. address this apparent contradiction by examining...
We investigated the relationship between partial epilepsy, MRI findings, and atypical language representation.A total of 102 patients (4 to 55 years) with left hemisphere epileptogenic zones were evaluated using three fMRI tasks obtained at 1.5 or 3T EPI BOLD techniques: verbal fluency, reading comprehension, auditory comprehension. maps visually interpreted a standard threshold rated as language.Atypical dominance occurred in 30 (29%) varied type (p < 0.01). Atypical representation 36%...
Abstract Functional magnetic resonance imaging (fMRI) in children is increasingly used clinical application and developmental research; however, little known how pediatric patient typically developing populations successfully complete studies. We examined success rates with epilepsy, attention deficit/hyperactivity disorder (ADHD), autism spectrum disorders (ASD), (TYP). also the affect of age, and, for ADHD populations, medication status on rates. defined a successful fMRI individual run...
Objective Functional magnetic resonance imaging is sensitive to the variation in language network patterns. Large populations are needed rigorously assess atypical patterns, which, even neurological populations, a minority. Methods We studied 220 patients with focal epilepsy and 118 healthy volunteers who performed an auditory description decision task. compared data‐driven hierarchical clustering approach commonly used priori laterality index (LI) threshold (LI < 0.20 as atypical)...
The timing and developmental factors underlying the establishment of language dominance are poorly understood. We investigated degree lateralization traditional frontotemporal modulatory prefrontal-cerebellar regions distributed network in children (n = 57) ages 4 to 12--a critical period for consolidation. examined relationship between strength neuropsychological measures task performance. fundamental is established by four with ongoing maturation functions as evidenced strengthening...
Background Impairment of executive function ( EF ), the goal‐directed regulation thoughts, actions, and emotions, drives negative outcomes is common across neurodevelopmental disorders including attention deficit hyperactivity disorder ADHD ) autism spectrum ASD ). A primary challenge to its amelioration heterogeneity in symptom expression within disorders. Parsing this necessary attain diagnostic precision, a goal NIMH Research Domain Criteria Initiative. We aimed identify transdiagnostic...
Abstract Language mapping is a key goal in neurosurgical planning. fMRI typically proceeds with focus on Broca's and Wernicke's areas, although multiple other language‐critical areas are now well‐known. We evaluated whether clinicians could use novel approach, including clinician‐driven individualized thresholding, to reliably identify six language regions, Area, Area (inferior, superior), Exner's Supplementary Speech Angular Gyrus, Basal Temporal Area. studied 22 epilepsy tumor patients who...
The mature human brain is lateralized for language, with the left hemisphere (LH) primarily responsible sentence processing and right (RH) suprasegmental aspects of language such as vocal emotion. However, it has long been hypothesized that in early life there plasticity allowing young children to acquire other cortical regions when LH areas are damaged. If true, what constraints on functional reorganization? Which can happens functions these ordinarily perform? We address questions by...
To characterize children with new-onset seizures presenting as status epilepticus at a tertiary care children's hospital.Prospectively collected data were reviewed from database derived mandated critical pathway. A total of 1,382 patients presented between 2001 and 2007.A 144 in epilepticus. The average age was 3.4 years. majority (72%) lasted 21 60 minutes. had no significant past medical history; one-fourth family history epilepsy. Five (4%) EEGs electrographic during the study, captured...
Neural networks for processing language often are reorganized in patients with epilepsy. However, the extent and location of within between hemisphere re-organization not established. We studied 45 patients, all a left seizure focus (mean age 22.8, onset 13.3), 19 normal controls 24.8) an fMRI word definition paradigm to assess regions. Individual patient SPM maps were compared group voxel-wise comparison; voxel was considered be significant if its z-value exceeded ∣2∣. Subsequently, we used...
Revisiting Lenneberg’s Hypotheses About Early Developmental Plasticity: Language Organization After Left-Hemisphere Perinatal Stroke Authors Elissa L. Newport Barbara Landau Anna Seydell-Greenwald Peter E. Turkeltaub Catherine Chambers Alexander W. Dromerick Jessic Carpenter Madiosn M. Berl William D. Gaillard PDF Article info Impact Citations License Published at 31. December 2017 https://doi.org/10.5964/bioling.9105 Issue: Vol. 11 (2017): Special Issue—50 Years Later: A Tribute to Eric...
Executive function, a set of cognitive skills important to social and academic outcomes, is specific area weakness in children with congenital heart disease (CHD). We evaluated the prevalence profile executive dysfunction heterogeneous sample school aged CHD, examined whether are receiving services support, identified risk factors for at age.Ninety-one patients completed questionnaires, including Behavior Rating Inventory Function (BRIEF) medical history questionnaire. An age- gender-...
<b>Objective: </b> To investigate the degree of language dominance in patients with left and right hemisphere seizure foci compared to normal volunteers using a fMRI reading comprehension task. <b>Methods: Fifty complex partial epilepsy, aged 8 56 years 33 volunteers, 7 34 had (1.5 T) neuropsychological testing. Participants silently named an object described by sentence visual control. Data were analyzed region interest (ROI) analysis based on t maps for inferior frontal gyrus (IFG),...
To investigate interhemispheric and intrahemispheric reorganization in patients with localization-related epilepsy.We studied 50 a left hemispheric focus 20 normal right-handed controls 3T echoplanar imaging blood oxygen level dependent functional MRI auditory-based word definition decision task. Data were analyzed using SPM 2. Using region of interest for Broca Wernicke areas an asymmetry index (AI), categorized as language (LL; AI > or = 0.20) atypical (AL; <0.20) region. The point maxima...
<b>Objective:</b> To investigate the presenting characteristics of new-onset afebrile seizures in infants (age 1–24 months) and yield neuroimaging. <b>Methods:</b> Prospective data were obtained from a standardized evaluation management plan mandated by critical care pathway. A total 317 presented with between 2001 2007. EEG was performed on 90.3%, head CT 94%, MRI 57.4%. <b>Results:</b> We found half had partial features to their seizures, yet evidence for primary generalized rare. The...
To study the neural networks reorganization in pediatric epilepsy, a consortium of imaging centers was established to collect functional data. Common paradigms and similar acquisition parameters were used. We studied 122 children (64 control 58 LRE patients) across five sites using EPI BOLD fMRI an auditory description decision task. After normalization MNI atlas, activation maps generated by FSL separated into three sub-groups distance method principal component analysis (PCA)-based...