A5101398735- Congenital Heart Disease Studies
- Insect Resistance and Genetics
- Histone Deacetylase Inhibitors Research
- Infant Development and Preterm Care
- Congenital heart defects research
- Congenital Diaphragmatic Hernia Studies
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- CRISPR and Genetic Engineering
- Pregnancy and preeclampsia studies
- Viral Infectious Diseases and Gene Expression in Insects
- Cardiovascular Issues in Pregnancy
- Birth, Development, and Health
- Coronary Artery Anomalies
- Travel Writing and Literature
- Insect and Arachnid Ecology and Behavior
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Clinical Nutrition and Gastroenterology
- Epigenetics and DNA Methylation
- Cardiovascular Function and Risk Factors
- Neonatal Respiratory Health Research
- Atomic and Subatomic Physics Research
- Receptor Mechanisms and Signaling
- Insect and Pesticide Research
University of Utah
2015-2024
Maine Medical Center
2020-2024
Primary Children's Hospital
2012-2024
University of Puerto Rico-Mayaguez
2009-2024
Maine Medical Center
2021-2023
Association of American Medical Colleges
2015
The University of Melbourne
2013
Peter MacCallum Cancer Centre
2013
European Institute of Oncology
2013
Walter and Eliza Hall Institute of Medical Research
2013
Abstract The genetic architecture of sporadic congenital heart disease (CHD) is characterized by enrichment in damaging de novo variants chromatin-modifying genes. To test the hypothesis that gene pathways contributing to forms CHD are distinct from those for recessive forms, we analyze 2391 whole-exome trios Pediatric Cardiac Genomics Consortium. We deploy a permutation-based gene-burden analysis identify and compound heterozygous genotypes genes, controlling confounding effects, such as...
Whether patient satisfaction scores can act as a catalyst for improving health care is highly debated. Some argue that pursuing overemphasized and potentially at odds with providing good because it leads providers to overtest overtreat patients bend unreasonable demands, all improve their ratings. Others cite studies showing high correlate improved outcomes. Ideally, assessing metrics will encourage empathy, communication, trust, shared decision making in the delivery process. From patient's...
To determine if neurodevelopmental deficits in children with single-ventricle physiology change age and early developmental scores predict 6-year outcomes.In the Single Ventricle Reconstruction Trial, Bayley Scales of Infant Development, Second Edition, were administered at 14 months age, parents completed Behavior Assessment System for Children, Edition (BASC-2) annually from ages 2 to 6 years. Scores classified as average, risk, or impaired. We calculated sensitivities, specificities,...
Understanding the conditionally-dependent clinical variables that drive cardiovascular health outcomes is a major challenge for precision medicine. Here, we deploy recently developed massively scalable comorbidity discovery method called Poisson Binomial based Comorbidity (PBC), to analyze Electronic Health Records (EHRs) from University of Utah and Primary Children’s Hospital (over 1.6 million patients 77 visits) comorbid diagnoses, procedures, medications. Using explainable Artificial...
Histone deacetylase (HDAC) inhibitors represent a new class of targeted anticancer agents. A number structural classes HDAC have been developed which several are in clinical trials, including phenylbutyrate (PB) and related compounds; the hydroxamic acids, suberoylanilide acid (SAHA) depsipeptide (FK-228); benzamides, MS-275 C1-994. This review will focus on our studies with inhibitors, SAHA is lead agent. X-ray crystallographic homologue (HDLP) demonstrated that group, most aliphatic chain...
Histone deacetylase inhibitors (HDACi) are anticancer agents that induce hyperacetylation of histones, resulting in chromatin remodeling and transcriptional changes. In addition, nonhistone proteins, such as the chaperone protein Hsp90, functionally regulated through mediated by HDACis. acetylation is thought to be primarily HDACs 1, 2, 3, whereas Hsp90 has been proposed specifically HDAC6. We compared molecular biologic effects induced an HDACi with broad HDAC specificity (vorinostat)...
OBJECTIVES: We measured behavioral, quality of life (QoL), and functional status outcomes for 6-year-old children with hypoplastic left heart syndrome enrolled in the Single Ventricle Reconstruction Trial. sought to compare these those normative population analyze risk factors worse within single-ventricle group. METHODS: Parent-response instruments included Vineland Adaptive Behavior Scales, Second Edition (Vineland-II) (primary outcome), Assessment System Children 2, Pediatric Quality Life...
BACKGROUND: Preterm delivery and low birth weight (LBW) are generally associated with worse outcomes in hypoplastic left heart syndrome (HLHS), but an individual preterm or small neonate may do well. We sought to explore the interactions between gestational age, weight, for age intermediate HLHS. METHODS: analyzed survival, growth, neurodevelopment, length of stay, complications 6 years subjects HLHS from Single Ventricle Reconstruction trial. Univariate multivariable survival regression...
Abstract Over the last two decades, heart centres have developed strategies to meet neurodevelopmental needs of children with congenital disease. Since publication guidelines in 2012, cardiac follow-up programmes become more widespread. Local programmes, however, been independently widely varying environments. We sought characterise variation structure and personnel programmes. A 31-item survey was sent all member institutions Cardiac Neurodevelopmental Outcome Collaborative....
Neurodevelopmental disabilities are commonly associated with congenital heart disease (CHD), but medical and sociodemographic factors explain only one-third of the variance in outcomes.
Quantification of fetal right ventricular (RV) function by 2D-echocardiography is challenging. Velocity vector imaging (VVI) an angle independent speckle tracking technique that assesses regional myocardial mechanics. Alteration in the deformation RV hypoplastic left heart syndrome (HLHS) unknown. This study aimed to evaluate mechanics HLHS.We retrospectively analyzed HLHS fetuses imaged at our center. Velocity, strain and rate were obtained using VVI. Global parameters compared between...
To describe neurobehavioral patterns in neonates with congenital heart disease (CHD).A cohort study describing performance of CHD requiring cardiac surgery. The were evaluated preoperatively and postoperatively the Neonatal Intensive Care Unit Network Neurobehavioral Scale (NNNS) scores compared published normative values. Clinical factors obtained by chart review to assess their association behavior. NNNS score pattern was previously reported profiles other high-risk populations.NNNS...
Intrauterine growth restriction (IUGR) increases the incidence of adult cardiovascular disease (CVD). The sex-specific developmental mechanisms for IUGR-induced and Western high-fat diet (HFD) modification CVD remain poorly understood. We hypothesized a maternal HFD in Sprague-Dawley rat would augment offspring through decreased cardiac function increased extracellular matrix (ECM) remodeling stiffness manner. or regular (Reg) was given from 5 wk before mating postnatal day (PND) 21. IUGR...