A5010315323- Fetal and Pediatric Neurological Disorders
- Neonatal and fetal brain pathology
- Prenatal Screening and Diagnostics
- Congenital Diaphragmatic Hernia Studies
- Advanced Neuroimaging Techniques and Applications
- Pregnancy and preeclampsia studies
- Neonatal Respiratory Health Research
- Domain Adaptation and Few-Shot Learning
- Genomics and Chromatin Dynamics
- Cleft Lip and Palate Research
- Cerebrospinal fluid and hydrocephalus
- Congenital Anomalies and Fetal Surgery
- Spinal Dysraphism and Malformations
- Assisted Reproductive Technology and Twin Pregnancy
- Gestational Diabetes Research and Management
- Breastfeeding Practices and Influences
- Prenatal Substance Exposure Effects
- Epigenetics and DNA Methylation
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related gene regulation
- Hate Speech and Cyberbullying Detection
- Cancer-related Molecular Pathways
- Hedgehog Signaling Pathway Studies
- Parvovirus B19 Infection Studies
- Genomic variations and chromosomal abnormalities
Brown University
2023-2025
Providence College
2023-2025
Tufts Medical Center
2013-2025
Hasbro Children's Hospital
2023-2025
University of California, San Francisco
2025
Infant
2025
Women & Infants Hospital of Rhode Island
2025
Tufts University
2012-2023
Tufts Children's Hospital
2012-2023
University of Pennsylvania
2023
Neocortical projection neurons arise from a pseudostratified ventricular epithelium (PVE) embryonic day 11 (E11) to E17 in mice. The sequence of neuron origin is systematically related mechanisms that specify neuronal class properties including laminar fate destination. Thus, the be assembled into deeper layers are earliest generated, while those superficial later generated neurons. also correlates with probability cell cycle exit (Q) and duration G1-phase (T(G1)) PVE. Both Q T(G1) increase...
Fetuses with isolated agenesis of the corpus callosum (ACC) are associated a broad spectrum neurodevelopmental disability that cannot be specifically predicted in prenatal neuroimaging. We hypothesized ACC may aberrant cortical folding. In this study, we determined altered patterning early primary sulci development fetuses using novel quantitative sulcal pattern analysis which measures deviations regional features (position, depth, and area) their intersulcal relationships 7 (27.1 ± 3.8...
Down syndrome (DS) is the most common liveborn autosomal chromosomal anomaly and a major cause of developmental disability. Atypical brain development resulting intellectual disability originate during fetal period. Perinatal interventions to correct such aberrant are on horizon in preclinical studies. However, we lack tools sensitively measure structural living human fetuses with DS. In this study, aimed develop safe precise neuroimaging measures monitor We measured growth patterns regional...
Isolated cerebral ventriculomegaly (IVM) is the most common prenatally diagnosed brain anomaly occurs in 0.2-1 % of pregnancies. However, knowledge fetal development IVM limited. There no prenatal predictor for to estimate individual risk neurodevelopmental disability 10 children. To characterize fetuses with and delineate their neuroanatomical variances, we performed comprehensive post-acquisition quantitative analysis magnetic resonance imaging (MRI). In volumetric analysis, MRI (n = 20,...
Food and nutrition-related factors have the potential to impact development of autism spectrum disorder (ASD) quality life for people with ASD, but gaps in evidence exist. On November 10, 2022, Tufts University's Friedman School Nutrition Science Policy Innovation Institute hosted a one-day meeting explore regarding relationships food nutrition ASD. This report summarizes presentations deliberations from meeting. Topics addressed included prenatal child dietary intake, microbiome, obesity,...
Abstract Objectives Maternal obesity increases a child’s risk of neurodevelopmental impairment. However, little is known about the impact maternal on fetal brain development. Methods We prospectively recruited 20 healthy pregnant women across range pre-pregnancy or first-trimester body mass index (BMI) and performed magnetic resonance imaging (MRI) their singleton fetuses. examined correlations between early pregnancy BMI regional volume living fetuses using volumetric MRI analysis. Results...
Fetal ventriculomegaly (VM) and its severity associated central nervous system (CNS) abnormalities are important indicators of high risk for impaired neurodevelopmental outcomes. Recently, a novel fetal brain age prediction method using two-dimensional (2D) single-channel convolutional neural network (CNN) with multiplanar MRI sections showed the potential to detect fetuses VM. This study examines diagnostic performance deep learning-based model distinguish VM (n = 317) from typically...
Malformations of cortical development (MCDs) are a heterogeneous family congenital brain malformations that originate from disturbed the cerebral cortex. MCDs can arise primary genetic disorders lead to dysfunction molecular processes controlling neuronal proliferation, migration, folding, or organization. also result secondary, disruptive causes, such as infection other in utero injuries. Sequelae include epilepsy, intellectual disability, and palsy, among symptoms, with high burden...
Isolated inferior vermian hypoplasia (iiVH) is one of the most common fetal cerebellar anomalies presenting for neurological counselling with controversial postnatal neurodevelopmental outcome. In present study, we characterised long-term outcome prenatally diagnosed iiVH at school age.We prospectively followed 20 children MRI diagnosis including their result and developmental age (mean 6.1 years±1.9 years SD) using a comprehensive age-appropriate testing battery, which encompassed...
Abstract Sulcal pits are thought to represent the first cortical folds of primary sulci during neurodevelopment. The uniform spatial distribution sulcal across individuals is hypothesized be predetermined by a human-specific protomap which related functional localization under genetic controls in early fetal life. Thus, it important characterize temporal and patterns brain that would provide additional information development human crucial insights into abnormal maturation. In this paper, we...
Fetal magnetic resonance imaging (MRI) has the potential to advance our understanding of human brain development by providing quantitative information cortical plate (CP) in vivo . However, for a reliable analysis volume and sulcal folding, accurate automated segmentation CP is crucial. In this study, we propose fully convolutional neural network automatic CP. We developed novel hybrid loss function improve accuracy adopted multi-view (axial, coronal, sagittal) aggregation with test-time...
Down syndrome (DS) is the most common genetic cause of developmental disabilities. Advanced analysis brain magnetic resonance imaging (MRI) has been used to find abnormalities and their relationship neurocognitive impairments in children adolescents with DS. Because factors affect development early fetal life, there a growing interest analyzing brains from living fetuses In this study, we investigated regional sulcal folding depth as well global cortical gyrification MRIs. Nine DS (29.1 ±...
<h3>BACKGROUND AND PURPOSE:</h3> Neurodevelopmental disability is common in twins with TTTS utero; however, the responsible neuropathology remains uncertain. We proposed to document frequency of brain abnormalities on clinical fetal MR images and determine if quantitative biometric analysis twin fetuses was different from those healthy control fetuses. <h3>MATERIALS METHODS:</h3> reviewed 33 pairs clinically evaluated our institution. Eighteen "healthy" were further studied comparison...
The accurate prediction of fetal brain age using magnetic resonance imaging (MRI) may contribute to the identification abnormalities and risk adverse developmental outcomes. This study aimed propose a method for predicting MRIs from 220 healthy fetuses between 15.9 38.7 weeks gestational (GA). We built 2D single-channel convolutional neural network (CNN) with multiplanar MRI slices in different orthogonal planes without correction interslice motion. In each fetus, multiple predictions were...
Human fetal brains show regionally different temporal patterns of sulcal emergence following a regular timeline, which may be associated with spatiotemporal gene expression among cortical regions. This study aims to quantify the timing and its variability across typically developing fetuses by fitting logistic curve presence or absence sulcus. We found that started from central temporo-parieto-occipital lobes frontal lobe, in most sulci was similar between 1 2 weeks. Small (< week) left...