A5064439029- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Cerebral Palsy and Movement Disorders
- Fetal and Pediatric Neurological Disorders
- Metabolism and Genetic Disorders
- Advanced Neuroimaging Techniques and Applications
- Prenatal Screening and Diagnostics
- Infant Nutrition and Health
- Birth, Development, and Health
- Pregnancy and preeclampsia studies
- Advanced MRI Techniques and Applications
- Congenital Heart Disease Studies
- Neuroscience of respiration and sleep
- Atomic and Subatomic Physics Research
- Mitochondrial Function and Pathology
- Parvovirus B19 Infection Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Functional Brain Connectivity Studies
- Botulinum Toxin and Related Neurological Disorders
- Congenital Diaphragmatic Hernia Studies
- Cerebrospinal fluid and hydrocephalus
- Family and Disability Support Research
- Cytomegalovirus and herpesvirus research
- Autism Spectrum Disorder Research
University of Southampton
2016-2025
Southampton Children's Hospital
2016-2025
Karolinska Institutet
2014-2025
University Hospital Southampton NHS Foundation Trust
2016-2025
Southampton General Hospital
2021-2022
Umeå University
2013
Linköping University
2013
University of Gothenburg
2013
Uppsala University
2013
Örebro University
2013
<h3>Importance</h3>Active perinatal care increases survival of extremely preterm infants; however, improved might be associated with increased disability among survivors.<h3>Objective</h3>To determine neurodevelopmental outcome in children at 2.5 years (corrected age).<h3>Design, Setting, and Participants</h3>Population-based prospective cohort consecutive infants born before 27 weeks gestation Sweden between 2004 2007. Of 707 live-born infants, 491 (69%) survived to years. Survivors were...
To investigate relationships between hand function, brain lesions, and corticomotor projections in children with unilateral cerebral palsy (CP).The study included 17 (nine males, eight females; mean age 11.4 [SD 2.4] range 7-16 y), CP at Gross Motor Function Classification System level I Manual Ability or II. Hand function was assessed the Box Blocks test Assisting Assessment (AHA). Conventional structural magnetic resonance images were visually for type, location, extent of lesions....
Abstract In order to quantify human brain development in vivo, high resolution magnetic resonance images of 158 normal subjects from infancy young adulthood were studied (age range 3 months–30 years, 71 males, 87 females). Data analysed using algorithms based on voxel‐based morphometry (VBM) (an objective whole processing technique) generate global volume measures brain, grey matter (GM) and white (GM). Gender‐specific WM GM volumes is characterised a piecewise polynomial growth curve model...
Background. In preterm infants there is a high risk of transmission cytomegalovirus (CMV) via breast milk from seropositive mothers with reactivation the virus during lactation. There little information about long term sequel early postnatally acquired CMV infection in pre-term infants. This study aimed to investigate whether was an increased frequency impaired neurodevelopmental outcome and sensorineural hearing loss through by CMV-positive milk. Methods. Twenty-two [median birth weight,...
Objectives. To further define the clinical spectrum of disease for pediatric and metabolic specialists, to suggest that general pediatrician neurologist consider succinic semialdehyde dehydrogenase (SSADH) deficiency in differential diagnosis patients with (idiopathic) mental retardation emphasize need accurate, quantitative organic acid analysis such patients. Patients. The features 23 (20 families) SSADH (4-hydroxybutyric aciduria) are presented. age at ranged from 3 months 25 years 11...
Abstract Aim: To investigate neurodevelopmental outcome and hearing in preterm children with breast milk transmitted human cytomegalovirus (HCMV) infection. Methods: Forty‐one (born before 32 weeks of gestation or birth weight <1500 g; 20 HCMV positive, 21 negative) from an original cohort 44 were examined at school age. Assessments included neurological examination, assessment motor [Movement Assessment Battery for Children (M‐ABC)] cognitive function [Kaufman (K‐ABC)], audiological...
To investigate the effect of gestational age at birth on frequency ultrasound-detected brain lesions in infants born <33 weeks gestation and to whether relationship between neonatal cranial ultrasound diagnosis neurodevelopmental outcome 8 years was independent age.Eight hundred forty-seven gestation, admitted a single tertiary referral center 1983 1988, underwent serial ultrasound. At assessed by structured neurologic examination, psychometric tests (Wechsler Intelligence Scale for...
Executive functions are frequently a weakness in children born preterm. We examined associations of executive and general cognitive abilities with brain structure preterm adolescents who were appropriate weight for gestational age have no radiological signs injury on neuroimaging.The Stockholm Neonatal Project (SNP) is longitudinal, population-based study (<36 weeks gestation) very low birth (<1501g) between 1988-1993. At 18 years (mean years, SD 2 weeks) 134 94 full term participants...
ABSTRACT Objective To assess the contribution of fetal magnetic resonance imaging (MRI) in fetuses MERIDIAN cohort diagnosed with ventriculomegaly (VM) as only abnormal intracranial finding on antenatal ultrasound. Methods This was a subgroup analysis study VM ultrasound women who had subsequent MRI examination within 2 weeks and for whom outcome reference data were available. The diagnostic accuracy reported relation to severity VM. difference measurements trigone size two methods clinical...
Aim The safety and efficacy of enteral feeding during hypothermia treatment following hypoxic-ischaemic encephalopathy has not been studied before, resulting in variations practice. Our study compared the benefits both early minimal delayed treatment. Methods retrospective cohort study, from January 2009 to December 2011, a Swedish cohort, who received hypothermia, UK feeding. Results In Sweden (n = 51), feeds were initiated at median 23.6 h full oral was achieved 9 days (range 3–23). 34),...
Background Heterozygous disruptions of FOXP2 were the first identified molecular cause for severe speech disorder: childhood apraxia (CAS), and yet few cases have been reported, limiting knowledge condition. Methods Here we phenotyped 28 individuals from 17 families with pathogenic -only variants (12 loss-of-function, five missense variants; 14 males; aged 2 to 62 years). Health development (cognitive, motor, social domains) examined, including language outcomes cross-linguistic analysis...
Highlights•School-aged children who had neonatal hypoxic-ischaemic encephalopathy and survived without CP have co-occurring memory impairments•Memory impairments occur in context of normal general cognitive abilities•Use real-world measures signifies everyday implications impairment•Therapeutic hypothermia is not wholly protective for functioningAbstractBackgroundNeonatal Hypoxic-Ischaemic Encephalopathy (HIE) increases risk neurodevelopmental impairment. Information on school-age function...