A5029087098- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Optical Imaging and Spectroscopy Techniques
- Congenital Heart Disease Studies
- Non-Invasive Vital Sign Monitoring
- Retinopathy of Prematurity Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- Advanced MRI Techniques and Applications
- Child and Adolescent Health
- Metabolism and Genetic Disorders
- Congenital Diaphragmatic Hernia Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Maternal Mental Health During Pregnancy and Postpartum
- Infant Nutrition and Health
- Genomic variations and chromosomal abnormalities
- Ubiquitin and proteasome pathways
- Emergency and Acute Care Studies
- Child and Adolescent Psychosocial and Emotional Development
- Mitochondrial Function and Pathology
- Photoacoustic and Ultrasonic Imaging
- Cerebrospinal fluid and hydrocephalus
- Trauma and Emergency Care Studies
- Chromosomal and Genetic Variations
St Thomas' Hospital
2020
King's College London
2001-2020
Chase Farm Hospital
2008
Barnet Hospital
2004-2008
University College London
1992-2006
Royal College of Paediatrics and Child Health
2004
Barnet and Chase Farm NHS Hospitals Trust
2001
Edgware Community Hospital
1995-1996
Middlesex University
1991-1992
University College Hospital
1990-1991
SUMMARY Studies of cerebral oxidative metabolism were carried out by phosphorous magnetic resonance spectroscopy during the first week life in 52 infants with clinical and/or biochemical evidence birth asphyxia. 15 died and 37 survivors assessed a wide range neurodevelopmental tests at one year age. The minimum recorded values for phosphocreatine/inorganic phosphate concentration ratio (an index metabolism) related to outcome. results showed significant relation between extent derangement...
SUMMARY The relation between the ultrasound appearance of brain and neurodc.velopmenial outcome aT eight years oi age was investigated in 206 infants born berwecn 1979 1992 at <3 3 wecks gestation (600 to ZSOOg birthweights). Only 4 prr cent 112 with normal scans discharge from neonatal unir developed major. disabling impairment. No signiiicant adverse effect uncomplicated periventricular haemorrhage detected. probability a major impairment ventricular dilatation or hydroccphalus 27 per...
Neuropsychological outcome at 14 to 15 years of age a cohort 75 participants (39 male, 36 female) born <33 weeks' gestation was investigated. Research conducted parallel recent MRI study by Stewart and colleagues which reported that 55% this had evidence brain abnormality. One aim the compare neuropsychological function in those very preterm children with without Compared control sample term adolescents, impairment only on measure word production. On measures attention, memory, perceptual...
To investigate the effect of gestational age at birth on frequency ultrasound-detected brain lesions in infants born <33 weeks gestation and to whether relationship between neonatal cranial ultrasound diagnosis neurodevelopmental outcome 8 years was independent age.Eight hundred forty-seven gestation, admitted a single tertiary referral center 1983 1988, underwent serial ultrasound. At assessed by structured neurologic examination, psychometric tests (Wechsler Intelligence Scale for...
<b>Background:</b> Several studies have shown an increased incidence of neurodevelopmental impairment in very preterm survivors at school age compared with controls. <b>Aim:</b> To compare findings the same cohort 8 years and 15 years. <b>Methods:</b> A total 151 224 eligible infants born before 33 weeks gestation from 1979 to 1982, who were living UK, assessed Items common both assessments evaluate changes function. The assessment included a structured neurological examination, psychometric...
The oxygenation of cerebral cytochrome oxidase in vivo was investigated eight newborn preterm infants. Near-infrared spectroscopy used to quantify changes the concentration oxidized ([CytO2]) observed during alterations arterial oxygen saturation (SaO2) range 85–99% and carbon dioxide tension (PaCO2) 4.3–9.6 kPa. No relation found between SaO2 [CytO2]. Alterations PaCO2 were positively related both [CytO2] total hemoglobin [( Hb]t). ranged from 0.09 0.33 (median 0.21) mumol.l-1.kPa-1. ratio...
SUMMARY The relation between neurodevelopmental status at one and eight years of age was investigated in a cohort 207 infants born 1979 1982 <33 weeks gestation. probability major disabling impairment only 1 per cent among 164 children with normal neurodevelopment year, but 56 for the 43 impaired 92 23 these who had impairments. Close correspondence found type diagnosed years. Neurodevelopmental year also predicted need extra educational provision by years, probabilities 9 without 87...
This study investigated whether in preterm children who had ventricular dilatation (VD) on neonatal cranial ultrasound outcome at age 8 years was influenced by the additional presence of germinal matrix haemorrhage — intraventricular (GMH–IVH). Six‐hundred and ninety‐nine infants (<33wks' gestation, mean 29.6wks [SD 2.1]) with either normal ( n =616; 286 females, 330 males), or VD =66; 32 34 males) without =17; 4 13 GMH–IVH were enrolled study. At assessed 567 (81%) 699 neurological...
Abstract Aim: To assess survival and neurodevelopmental outcome of extremely preterm infants over a 20‐year period at single tertiary neonatal centre. Methods: All between 22 25 +6 weeks gestation admitted to UK centre 1981 2000 were enrolled prospectively. Infants in the same gestational age range who born alive hospital but not unit also identified 1991–2000. surviving received neurological developmental assessment corrected 1 year. Results: There was progressive increase all ages period....
Preterm babies are physiologically hypotonic, which causes their posture to be flattened when lying in the prone position. This may persist beyond term. In a prospective, randomised, controlled, double blind trial of postural support carried out on 45 born at less than 33 weeks gestation, we showed that infants positioned with specific hip during period intensive care had significantly fewer features age equivalent
The aim of this study was to investigate the association between epilepsy and perinatal brain injury in a cohort 610 infants born preterm at <33 weeks' gestation. prevalence 4.3% as determined by postal questionnaire survey. Most children with (16 24) had high-risk cranial ultrasound lesions including haemorrhagic parenchymal infarction (HPI), posthaemorrhagic hydrocephalus, cystic periventricular leukomalacia (PVL). Of all our lesions, those were more likely have HPI significantly less PVL,...
Maternal ante- and postnatal anxiety have been associated with children's socio-emotional development. Moreover, maternal has studied as both a contributing factor consequence of preterm birth, children born are more likely to develop behavioural problems compared term-born controls. This study investigated the association between measured soon after birth mental health in 215 ex-preterm children, at <33 weeks, who participated Evaluation Preterm Imaging Study. Children were followed-up...
AbstractMagnetic resonance spectroscopy and near infrared provide complimentary information about cerebral oxidative metabolism haemodynamics are valuable methods for investigating normal brain development the pathogenesis of perinatal injury. Magnetic can be used to measure in tissue concentrations important phosphorus compounds that involved metabolism, notably adenosine triphosphate, phosphocreatine inorganic orthophosphate: intracellular pH also estimated. Abnormalities indicating...
Neuropsychological outcome at 14 to 15 years of age a cohort 75 participants (39 male, 36 female) born <33 weeks’gestation was investigated. Research conducted parallel recent MRI study by Stewart and colleagues which reported that 55% this had evidence brain abnormality. One aim the compare neuropsychological function in those very preterm children with without Compared control sample term adolescents, impairment only on measure word production. On measures attention, memory, perceptual...
Partial trisomy 4p was found in a child with dysmorphic features. Cytogenetic investigations the parents revealed an intrachromosomal insertion mother, 46,XX,ins (4)(q313p14p16). The proband trisomic for 4p(p14p16) as result of recombination event mother's chromosome 4 at meiosis. clinical features are compared those literature.
A family is presented with short stature, femoral epiphyseal dysplasia, mild vertebral changes, and sensorineural deafness inherited as an autosomal dominant trait. Myopia retinal detachment presenting in adult life were also present some affected members. We suggest that this disorder may be a distinct entity within the spondyloepiphyseal dysplasia group of disorders.