A5013351508- Neonatal and fetal brain pathology
- Infant Development and Preterm Care
- Neonatal Respiratory Health Research
- Breastfeeding Practices and Influences
- Anesthesia and Neurotoxicity Research
- Thermal Regulation in Medicine
- Traumatic Brain Injury and Neurovascular Disturbances
- Advanced MRI Techniques and Applications
- Cardiac Arrest and Resuscitation
- Child Nutrition and Feeding Issues
- Art Therapy and Mental Health
- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Language Development and Disorders
- Infant Health and Development
- Child Therapy and Development
- Tryptophan and brain disorders
- Infant Nutrition and Health
- Maternal Mental Health During Pregnancy and Postpartum
- Renal function and acid-base balance
- Stress Responses and Cortisol
- Child and Adolescent Health
- High Altitude and Hypoxia
- Functional Brain Connectivity Studies
- Ion channel regulation and function
John Radcliffe Hospital
2013-2024
Oxford University Hospitals NHS Trust
2013-2022
University of Oxford
2020-2022
University College Cork
2012
University College London
1999-2006
Royal College of Paediatrics and Child Health
2004-2005
The Royal Free Hospital
2005
King's College London
2004
Queen Mary University of London
1993
Objective Assess the relationship of time to first expression after very preterm birth and mothers’ own milk quantity. Design A cohort study (nested within a randomised trial). Setting Four neonatal units in UK. Patients 132 mothers single or twin infants born at 23+0 31+6 weeks postmenstrual age. Exposures Time attempt express birth. Primary outcomes 24-hour mother’s yield on days 4, 14 21 Results Median was 6 hours. 51.7% expressed hours (62/120) 48.3% more than (58/120). Expressing...
<b>Background:</b> Several studies have shown an increased incidence of neurodevelopmental impairment in very preterm survivors at school age compared with controls. <b>Aim:</b> To compare findings the same cohort 8 years and 15 years. <b>Methods:</b> A total 151 224 eligible infants born before 33 weeks gestation from 1979 to 1982, who were living UK, assessed Items common both assessments evaluate changes function. The assessment included a structured neurological examination, psychometric...
Abstract Hypothermia after perinatal hypoxia‐ischemia (HI) is neuroprotective; the precise brain temperature that provides optimal protection unknown. To assess pattern of injury with 3 different rectal temperatures, we randomized 42 newborn piglets: (Group i) sham‐normothermia (38.5–39°C); ii) sham‐33°C; iii) HI‐normothermia; iv) HI‐35°C; and v) HI‐33°C. Groups iii through v were subjected to transient HI insult. ii, iv, cooled their target temperatures between 2 26 hours resuscitation....
Importance Human milk feeding is a key public health goal to optimize infant and maternal/parental health, but global lactation outcomes do not meet recommended duration exclusivity. There are connections between mental health. Objective To appraise all available evidence on whether the provision of relaxation interventions lactating individuals improves well-being. Data Sources Embase, MEDLINE, CINAHL, Allied Complementary Medicine Database, Web Science, Cochrane Library were searched...
OBJECTIVES. Fundamental questions remain about the precise temperature providing optimal neuroprotection after perinatal hypoxia-ischemia (HI). Furthermore, if hypothermia delays onset of neurotoxic cascade and secondary impairment in cerebral energy generation, “latent phase” may be prolonged, thus extending period when additional treatments effective. The aims this study were to investigate effects delayed systemic cooling at either 33°C or 35°C on following: (1) latent-phase duration, (2)...
Abstract There is evidence showing that both maturational and environmental factors can impact on later language development. On the one hand, preterm birth has been found to increase risk of deficits in preschool school years. Preterm children show poorer auditory discrimination, reading difficulties, poor vocabulary, less complex expressive lower receptive understanding than their matched controls. other socioeconomic status (SES) indicators (i.e., income, education occupation) have be...
OBJECTIVE. We sought to compare the prognostic utilities of early MRI spin-spin relaxometry and proton magnetic resonance spectroscopy in neonatal encephalopathy. METHODS. Twenty-one term infants with encephalopathy were studied at a mean age 3.1 days (range: 1–5). Basal ganglia, thalamic frontal, parietal, occipital white matter relaxation times determined from images echo 25 200 milliseconds. Metabolite ratios an 8-mL thalamic-region voxel (1H point-resolved spectroscopy; time 270...
Abstract This article explores the hypothesis that artwork created during art therapy may activate neurological structures of brain enabling non-verbal early experience to become known. Art making is a right activity and processed in brain. can attempt access emotional trauma which has caused damage hemisphere Mess often present when working with children who have had abuse or neglect. The investigates meaning this through review research on attachment, brain, linking it case material. Early...
I was excited when this book arrived for me to review. At last, thought, a that will increase art therapists clinical credence, scientifically researched evidence give us knowledge and skills underpin our understanding. My interest in neuroscience spans many years, use understanding conceptualise meaning the sometimes difficult understand communications client/patient brings therapy room. On reading, discover various chapters detailed theoretical of brain regions, how neural pathways grow...
Premature birth is the leading cause of neonatal death and can major morbidity. Maximising amount maternal breastmilk given to very premature infants important improve outcomes, but this be challenging for parents. Parents receiving care also have high rates anxiety distress. There growing evidence impact relaxation interventions on lactation, as well mental health. The trial will assess whether a brief self-directed visualisation intervention, recommended use several times day during...
Clonidine and glutamate were applied by iontophoresis to cells in the superficial 3 laminae of spinal cord anaesthetised rat. Only that excited (up 150 nA) studied. Some spontaneously active could be clonidine 100 nA). However, when non-spontaneous cells, had no effect at any dose level. When ejected a cyclic pattern alternating with ejection, powerfully amplified response many stimulus. This was seen only on small-amplitude spikes low-threshold (LT) receptive fields. The amplification often...
A 2.18 kg male baby was born by elective caesarean section at 34+3 weeks to a primiparous mother with autosomal dominant congenital methaemoglobinaemia (HbM Iwate) and gestational diabetes. Having been asymptomatic throughout her life, she developed significant respiratory symptoms in the third trimester, possibly due superimposed acquired methaemoglobinaemia, which necessitated hospitalisation, red cell exchange early delivery of infant. At birth, remained cyanosed despite good effort, …
The beneficial health and economic impacts of breastfeeding are considerable. However the majority babies in UK not exclusively by 6 weeks age. first few life therefore a critical period to facilitate breastfeeding. Health professionals must have thorough knowledge normal patterns order minimise unnecessary interference, an understanding how protect relationship when medical problems occur.
Abstract When infants cannot directly breastfeed after birth, mothers are advised to initiate lactation through mechanical expression. Families recommended target an expression volume of at least 500–750 mL by Day 14 as this is considered a ‘critical window’ establish milk supply. This challenging for many very preterm birth. article explores the relationship early quantity and later full breastmilk feeding ‘gold standard’ outcome, using statistical techniques designed diagnostic tests. A...