A5072106301- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Cystic Fibrosis Research Advances
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Urologic and reproductive health conditions
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Valve Diseases and Treatments
- Bladder and Urothelial Cancer Treatments
- Renal Transplantation Outcomes and Treatments
- Cardiac Structural Anomalies and Repair
- Inhalation and Respiratory Drug Delivery
- Health Systems, Economic Evaluations, Quality of Life
- Mechanical Circulatory Support Devices
- Tracheal and airway disorders
- Gallbladder and Bile Duct Disorders
- Advanced Radiotherapy Techniques
- MRI in cancer diagnosis
- Liver Disease and Transplantation
- Infective Endocarditis Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Organ Donation and Transplantation
Cystic Fibrosis Trust
2019-2025
Monash University
2020-2024
Royal Brompton Hospital
2021-2023
Imperial College London
2021
Brunel University of London
2021
London School of Hygiene & Tropical Medicine
2010-2020
Royal College of Surgeons of England
2013-2019
The Honourable Society of Lincoln's Inn
2016-2018
University College London
2001-2018
Cambridge University Hospitals NHS Foundation Trust
2016
Clinically significant nonmetastatic prostate cancer (PCa) is currently treated using whole-gland therapy. This approach effective but can have urinary, sexual, and rectal side effects. To report on 5-yr PCa control following focal high-intensity focused ultrasound (HIFU) therapy to treat individual areas of within the prostate. was a prospective study 625 consecutive patients with clinically undergoing HIFU (Sonablate) in secondary care centres between January 1, 2006 December 31, 2015. A...
Ivacaftor is the first in a class of drugs, CFTR modulators, that target underlying defect cystic fibrosis (CF). This long-term observational safety study evaluated CF disease progression patients treated with ivacaftor real-world setting for up to 5 years.Data from existing US and UK patient registries were used assess longitudinal patterns lung function, nutritional status, pulmonary exacerbations hospitalizations, CF-related diabetes (CFRD), Pseudomonas aeruginosa ivacaftor-treated vs...
Oncologists traditionally assess their patients' ECOG performance status (PS), and few studies have evaluated the accuracy of these assessments. In this study, 101 patients attending a rapid access clinic at Papworth Hospital with diagnosis lung cancer were asked to own PS score on scale between 0 4. Patients' scores compared assessment them made by oncologists. Of 98 primary non-small-cell (NSCLC) small-cell (SCLC), weighted κ statistics showed agreement patient oncologist 0.45. Both...
No AccessJournal of UrologyAdult Urology1 Mar 2013Transperineal Magnetic Resonance Image Targeted Prostate Biopsy Versus Transperineal Template in the Detection Clinically Significant Cancer Veeru Kasivisvanathan, Robert Dufour, Caroline M. Moore, Hashim U. Ahmed, Mohamed Abd-Alazeez, Susan C. Charman, Alex Freeman, Clare Allen, Kirkham, Jan van der Meulen, and Mark Emberton KasivisvanathanVeeru Kasivisvanathan Division Surgery Interventional Sciences, University College London, United...
Abstract Objective To devise and test a system with which to evaluate abnormalities on muscle biopsy samples obtained from children diagnosed juvenile dermatomyositis (DM). Methods We established an International Consensus Group Juvenile DM Biopsy carried out 2 phases of consensus process scoring workshops. sections (n = 33) were stained by standard methods. The tool was based 4 domains change: inflammatory, vascular, fiber, connective tissue. Using Latin square design, scored 11 experts for...
To assess the performance of multiparametric magnetic resonance imaging (mp-MRI) in patients with previous negative transrectal ultrasound (TRUS) guided prostate biopsy.Fifty-four at least 1 TRUS biopsy underwent mp-MRI form T2-weighted, diffusion-weighted, and dynamic contrast-enhanced imaging. This was followed by transperineal template systematic biopsies. Analysis done based on 2 sectors per prostate, right left (108 out 54 prostates). scored using an ordinal scale to 5 suspicion...
Outcomes of liver transplantations from donation after circulatory death (DCD) donors may be inferior to those achieved with brain (DBD) donors. The impact using DCD is likely depend on specific national practices. We compared risk-adjusted graft loss and recipient mortality transplantation DBD livers in the UK.Prospective cohort study. Multivariable Cox regression propensity score matching were used estimate HR.7 transplant centres National Health Service (NHS) hospitals England...
Transrectal prostate biopsy has limited diagnostic accuracy. Prostate Imaging Compared to Transperineal Ultrasound-guided for significant cancer Risk Evaluation (PICTURE) was a paired-cohort confirmatory study designed assess accuracy of multiparametric magnetic resonance imaging (mpMRI) in men requiring repeat biopsy. All underwent 3 T mpMRI and transperineal template mapping biopsies (TTPM biopsies). Multiparametric MRI reported using Likert scores radiologists were blinded initial...
Rationale: Ivacaftor can greatly improve clinical outcomes in people with cystic fibrosis (CF) and has been shown to have vitro antibacterial properties, yet the long-term microbiological of treatment are unknown.Objectives: To investigate changes respiratory microbiology associated ivacaftor use.Methods: This was a retrospective cohort study using data from UK CF Registry 2011-2016. Primary outcome annual prevalence ratios for key pathogens between users their contemporaneous comparators....
To investigate the outcome of patients in atrial fibrillation (AF) following mitral valve repair, clinical and echocardiographic follow-up was undertaken 400 consecutive who underwent valvuloplasty from 1987 to 1999.The main indications for surgery were degenerative (81.4%), endocarditis (7.1%), rheumatic (6.6%), ischemic (4.6%), traumatic (0.3%) disease. After excluding 6 paced 1 patient nodal rhythm, we compared outcomes 152 AF against 241 sinus rhythm. For versus those more older (mean...
Objective We assessed the impact of comorbidity on mortality in three periods after liver transplantation (first 90 days, days–5 years and 5–10 years). Design Prospective cohort study using records from UK Liver Transplant Audit (UKLTA) linked to Hospital Episode Statistics (HES), an administrative database hospital admissions English National Health Service (NHS). Comorbidities relevant for were identified 10th revision International Classification Diseases (ICD-10) codes HES year preceding...
We compared thromboembolic events, major haemorrhage and death after total hip replacement in patients receiving either aspirin or low-molecular-weight heparin (LMWH). analysed data from the National Joint Registry for England Wales linked to an administrative database of hospital admissions English Health Service. A 108 584 operated on between April 2003 September 2008 were included followed up 90 days. Multivariable risk modelling propensity score matching used estimate odds ratios (OR)...
Objectives To study muscle biopsy tissue from patients with juvenile dermatomyositis (JDM) in order to test the reliability of a score tool designed quantify severity histological abnormalities when applied biceps humeri addition quadriceps femoris. Additionally, evaluate whether elements correlate clinical measures disease severity. Methods 55 JDM and data available were included. Biopsy samples (33 quadriceps, 22 biceps) prepared stained using standardised protocols. A Latin square design...
We compared thromboembolic events, major haemorrhage and death after knee replacement in patients receiving either aspirin or low-molecular-weight heparin (LMWH). Data from the National Joint Registry for England Wales were linked to an administrative database of hospital admissions English Health Service. A total 156,798 between April 2003 September 2008 included followed 90 days. Multivariable risk modelling was used estimate odds ratios adjusted baseline factors (AOR). An AOR < 1...
We evaluated the detection of clinically significant prostate cancer using magnetic resonance imaging targeted biopsies and compared visual estimation to image fusion targeting in patients requiring repeat biopsies.
Robot-assisted radical prostatectomy (RARP) has been rapidly adopted without robust evidence comparing its functional outcomes against laparoscopic (LRP) or open retropubic (ORP) approaches. This study compared patient-reported following RARP, LRP ORP. All men diagnosed with prostate cancer in England during April – October 2014 who underwent were identified from the National Prostate Cancer Audit and mailed a questionnaire 18 months after diagnosis. Group differences sexual, urinary, bowel...
Introduction Target trial emulation is a framework for evaluating the effects of treatments using observational data. The approach involves specifying key elements protocol target (a randomised controlled designed to address question interest) and then describing how best emulate Recent years have seen an uptake in several disease areas, although there are limited examples cystic fibrosis (CF). This describes study which aims assess applicability CF. We aim existing CF what extent results...