A5006979396- Transplantation: Methods and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Viral Infections and Immunology Research
- Mechanical Circulatory Support Devices
- Statistical Methods and Bayesian Inference
- Aortic Disease and Treatment Approaches
- Statistical Methods in Clinical Trials
- Pulmonary Hypertension Research and Treatments
- Organ and Tissue Transplantation Research
- Aortic aneurysm repair treatments
- Advanced Causal Inference Techniques
- Statistical Methods and Inference
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pain Management and Treatment
- Cytomegalovirus and herpesvirus research
- Obstructive Sleep Apnea Research
- Tracheal and airway disorders
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
University of London
2018-2025
London School of Hygiene & Tropical Medicine
2017-2025
Faculty of Public Health
2025
Papworth Hospital
2007-2022
Transnational Press London
2021
Hull Royal Infirmary
2020
University of Leeds
2013-2018
Glenfield Hospital
2017
MRC Biostatistics Unit
2007-2016
University of Sheffield
1998-2016
To update the European System for Cardiac Operative Risk Evaluation (EuroSCORE) risk model. A dedicated website collected prospective and outcome data on 22 381 consecutive patients undergoing major cardiac surgery in 154 hospitals 43 countries over a 12-week period (May–July 2010). Completeness accuracy were validated during collection using mandatory field entry, error range checks after summary feedback confirmation by responsible officers multiple logic checks. Information was obtained...
Background— Myocyte necrosis as a result of elective percutaneous coronary intervention (PCI) occurs in approximately one third cases and is associated with subsequent cardiovascular events. This study assessed the ability remote ischemic preconditioning (IPC) to attenuate cardiac troponin I (cTnI) release after PCI. Methods Results— Two hundred forty-two consecutive patients undergoing PCI undetectable preprocedural cTnI were recruited. Subjects randomized receive IPC (induced by three...
Epidermal growth factor is found in high concentrations urine, and its receptor (EGFr) has been identified certain bladder tumors. This study was performed to determine whether positivity the tumor associated with a poor clinical outcome. One hundred one patients newly diagnosed cancer were studied prospectively by immunohistochemical staining for EGFr. There 76 men 25 women, mean follow-up of 30 months; 49 had tumors invading muscle: 18 pTl (tumor lamina propia) 34 pTa confined urothelium)....
Among patients with suspected coronary heart disease (CHD), rates of invasive angiography are considered too high.To test the hypothesis that among CHD, cardiovascular magnetic resonance (CMR)-guided care is superior to National Institute for Health and Care Excellence (NICE) guidelines-directed myocardial perfusion scintigraphy (MPS)-guided in reducing unnecessary angiography.Multicenter, 3-parallel group, randomized clinical trial using a pragmatic comparative effectiveness design. From 6...
To investigate whether rituximab, an anti-B cell therapy, improves symptoms of fatigue and oral dryness in patients with primary Sjögren's syndrome (SS). We conducted a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial that included health economic analysis. Anti-Ro-positive SS, symptomatic fatigue, were recruited from 25 UK rheumatology clinics August 2011 to January 2014. Patients centrally randomized receive either intravenous (IV) placebo (250 ml saline) or...
Summary. Many chronic diseases have a natural interpretation in terms of staged progression. Multistate models based on Markov processes are well-established method estimating rates transition between stages disease. However, diagnoses disease sometimes subject to error. The paper presents general hidden model for simultaneously and probabilities stage misclassification. Covariates can be fitted both the misclassification probabilities. For example, study abdominal aortic aneurysms by...
To determine the symptomatic and urodynamic outcome of elective prostatectomy to establish whether is influenced or can be predicted by preoperative measurements.Prospective non-randomised study with follow up at a mean 11 months after operation. Most men were assessed jointly urologist general practitioner.Department urology in teaching hospital serving large district population.253 Men listed for because symptoms low urinary flow rates (less than 15 ml/s) excluding those already on waiting...
To review the clinical and polysomnographic characteristics of idiopathic hypersomnia as well long-term response to treatment. The Respiratory Support Sleep Centre at Papworth Hospital, Cambridge, UK. A large database more than 6000 patients with sleep disorders was reviewed. retrospective study 77 performed. Comparison a similar group narcolepsy drug treatment assessed in 61 over mean follow-up 3.8 years. Idiopathic 60% prevalent narcolepsy. showed that those were likely have prolonged...
<h3>Objective</h3> To investigate the relation between severity of pulmonary hypertension and outcome medical treatment. <h3>Methods</h3> 98 patients with primary hypertension—nine (6%) systemic disease 39 (27%) thromboembolic hypertension—received treatment were followed 1982 1995. They given long term intravenous prostaglandin (either epoprostenol (n = 61) or iloprost 13)) conventional oral anticoagulants 24) without calcium channel blockers. Event-free survival was measured to death...
Oncologists traditionally assess their patients' ECOG performance status (PS), and few studies have evaluated the accuracy of these assessments. In this study, 101 patients attending a rapid access clinic at Papworth Hospital with diagnosis lung cancer were asked to own PS score on scale between 0 4. Patients' scores compared assessment them made by oncologists. Of 98 primary non-small-cell (NSCLC) small-cell (SCLC), weighted κ statistics showed agreement patient oncologist 0.45. Both...
SUMMARY We review applications of Gibbs sampling in medicine, involving longitudinal, spatial, covariate measurement and survival models. Applications immunology, pharmacology, transplantation, cancer screening, industrial epidemiology genetic are discussed.
This study demonstrates the importance of analyzing survival by cause death in order to achieve a better understanding prognostic indicators involved. It further emphasizes need for analysis risk factors both univariate and multivariate models, danger making judgements based on premature data follow-up after heart transplantation. Survival following transplantation is characterized major hazards early due infection rejection late graft loss coronary occlusive disease (COD). summarizes...
Measurement of changes in patients' perceptions how differing states health affect their lives and determination the ability preoperative variables to predict outcome after coronary artery bypass grafting.Prospective study with completion questionnaires before grafting at three months, one year, five years afterwards.Regional cardiothoracic centre.100 Male patients all aged below 60 time operation, who were two surgeons.Patients' assessment state terms functional capacity aspects distress,...