A5037318979- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Fatty Acid Research and Health
- Cardiac Ischemia and Reperfusion
- Coronary Interventions and Diagnostics
- Cardiac Arrest and Resuscitation
- Acute Myocardial Infarction Research
- Eicosanoids and Hypertension Pharmacology
- Cardiac Valve Diseases and Treatments
- Advanced MRI Techniques and Applications
- Cardiovascular Syncope and Autonomic Disorders
- Heart Failure Treatment and Management
- Cardiomyopathy and Myosin Studies
- Cardiac Structural Anomalies and Repair
- Sarcoidosis and Beryllium Toxicity Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Nausea and vomiting management
- Infant Health and Development
- Thermodynamic and Exergetic Analyses of Power and Cooling Systems
- Attention Deficit Hyperactivity Disorder
- Heart Rate Variability and Autonomic Control
Papworth Hospital NHS Foundation Trust
2013-2024
Papworth Hospital
2009-2024
Royal Victoria Hospital
2020-2024
University of Ulster
2020-2024
The Royal Melbourne Hospital
2010-2019
University of Toronto
2019
Southlake Regional Health Center
2019
Cambridge University Health Partners
2019
University of Cambridge
2007-2015
The University of Melbourne
2010-2014
Background— Myocyte necrosis as a result of elective percutaneous coronary intervention (PCI) occurs in approximately one third cases and is associated with subsequent cardiovascular events. This study assessed the ability remote ischemic preconditioning (IPC) to attenuate cardiac troponin I (cTnI) release after PCI. Methods Results— Two hundred forty-two consecutive patients undergoing PCI undetectable preprocedural cTnI were recruited. Subjects randomized receive IPC (induced by three...
Background— Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted postprandially that promotes myocardial glucose uptake. The active amide GLP-1 (7-36) degraded by the enzyme DPP-4, and drugs inhibit this (such as sitagliptin) have been introduced to treat type 2 diabetes. We assessed hypothesis increasing plasma concentration of DPP-4 inhibition would protect heart from ischemic left ventricular (LV) dysfunction during dobutamine stress echocardiography in patients with coronary...
Atrial Remodeling in Fibrillation. Introduction: The nature of the atrial substrate thought to contribute toward maintaining fibrillation (AF) outside pulmonary veins remains poorly defined. Therefore, our objective was determine whether patients with paroxysmal and persistent AF have an abnormal electroanatomic within left atrium (LA). Methods Results: Thirty‐one (17 14 AF) were compared 15 age‐matched controls left‐sided supraventricular tachycardia (SVT). High‐density 3‐dimensional maps...
Background Identification and elimination of nonpulmonary vein targets may improve clinical outcomes in patients with persistent atrial fibrillation (AF). We report on the use a novel, noncontact imaging mapping system that uses ultrasound to reconstruct chamber anatomy measures timing density dipolar, ionic activation (ie, charge density) across myocardium guide ablation arrhythmias. Methods The prospective, nonrandomized UNCOVER AF trial (Utilizing Novel Dipole Density Capabilities...
BACKGROUND. Spatial resolution in cardiac activation maps based on voltage measurement is limited by far-field interference. Precise characterization of electrical sources would resolve this limitation; however, practical charge-based mapping has not been achieved.
The goal of this study was to develop a risk score model for patients with Brugada syndrome (BrS).Risk stratification in BrS is significant challenge due the low event rates and conflicting evidence.A multicenter international cohort no previous cardiac arrest used evaluate role 16 proposed clinical or electrocardiogram (ECG) markers predicting ventricular arrhythmias (VAs)/sudden death (SCD) during follow-up. Predictive were incorporated into model, validated by using out-of-sample...
AimsPulmonary vein isolation (PVI) is the cornerstone of catheter ablation atrial fibrillation (AF). The intervenous ridge (IVR) may be incorporated into strategies to achieve PVI; however, randomized trials are lacking. We performed a multi-centre international study compare outcomes (i) circumferential antral PVI (CPVI) alone (minimal) vs. (ii) CPVI with IVR individual (maximal).
The transesophageal echo probe (TEE) is commonly used before and during atrial fibrillation (AF) ablation under general anesthesia (GA). We sought to determine the potential contribution of TEE esophageal injury after pulmonary vein isolation (PVI) alone for paroxysmal AF.Seventy-six patients undergoing PVI with TEE, PVI/TEE, 16 without (PVI/No TEE), 27 any left (TEE/No LA ablation) GA were included. Posterior wall was power (20-25 W) time limited (electrogram attenuation or ≤30 s)....
Outcome of persistent atrial fibrillation (AF) ablation remains suboptimal. Techniques employed to reduce arrhythmia recurrence rate are more likely be embraced if cost-effectiveness can demonstrated. A single-centre observational study assessed whether use general anaesthesia (GA) in AF improved outcome and was cost-effective. Two hundred ninety two patients undergoing first procedures for under conscious sedation or GA were followed. End points freedom from listing repeat at 18 months 1...
Objectives Pulsed field ablation (PFA) is a promising new modality for the treatment of atrial fibrillation (AF) that has recently become available in UK National Health Service (NHS). We provide first known economic evaluation technology. Methods A cost-comparison model was developed to compare expected 12-month costs treating AF using pentaspline PFA catheter compared with cryoablation single hypothetical patient. Model parameters were based on recent cost-effectiveness analysis by...
Mapping of atrial fibrillation (AF) involves identification low-voltage regions associated with complex fractionated electrograms (CFE) which theoretically represent abnormal substrate and targets for ablation. Whether CFE areas also identify during paced rhythm is unknown. Twelve patients persistent AF undergoing ablation had high-density three-dimensional electroanatomic maps created (24 maps) the mean voltage was compared eight segments left atrium (LA). The following were correlated...
Electroanatomic Properties of the Pulmonary Veins. Introduction: Rapid PV activity is critical in initiating and maintaining AF. The underlying substrate responsible for this remains uncertain. We sought to identify if patients with paroxysmal (PAF) persistent atrial fibrillation (PeAF) have an abnormal within pulmonary veins (PVs). Methods Results: Thirty-nine AF (21 PAF, 18 PeAF) were compared 15 age-matched controls left-sided accessory pathways (AVRT). High-density 3D electroanatomic...
<h3>Objective</h3> Studies have shown beneficial effects of cardiac resynchronisation therapy (CRT) on mortality among patients with heart failure. However the incremental benefits in survival from CRT a defibrillator (CRT-D) are unclear. The choice appropriate device remains unanswered. <h3>Method</h3> This is single-centre observational study tertiary centre. Patients (n=500) implanted pacing alone (CRT-P) (n=354) and CRT-D (n=146) were followed for at least 2 years (mean 29 months, SD 14...
Enhancement of myocardial glucose uptake may reduce fatty acid oxidation and improve tolerance to ischemia. Hyperglycemia, in association with hyperinsulinemia, stimulates this metabolic change but have deleterious effects on left ventricular (LV) function. The incretin hormone, glucagon-like peptide-1 (GLP-1), also has favorable cardiovascular effects, emerged as an alternative method altering substrate utilization. In patients coronary artery disease (CAD), we investigated: (1) the effect...