A5055130042- Cardiac pacing and defibrillation studies
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Ion channel regulation and function
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Coronary Interventions and Diagnostics
- Neurological disorders and treatments
- Heart Failure Treatment and Management
- Pericarditis and Cardiac Tamponade
- Cardiac Ischemia and Reperfusion
- Musculoskeletal pain and rehabilitation
- Neuroscience and Neural Engineering
- Cardiomyopathy and Myosin Studies
- Cardiac tumors and thrombi
- Pain Mechanisms and Treatments
- Pain Management and Placebo Effect
- Muscle activation and electromyography studies
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and Diving-Related Complications
- Takotsubo Cardiomyopathy and Associated Phenomena
- Electrostatic Discharge in Electronics
- Trauma and Emergency Care Studies
- Frailty in Older Adults
Queen Elizabeth Hospital King's Lynn NHS Foundation Trust
2022-2023
Papworth Hospital
2006-2022
Papworth Hospital NHS Foundation Trust
2016-2019
James Paget University Hospital
2019
West Suffolk Hospital
2019
University of Cambridge
2010-2014
Bedford Hospital
2013-2014
Physiological Society
2010-2012
MRC Biostatistics Unit
2009
Background— Myocyte necrosis as a result of elective percutaneous coronary intervention (PCI) occurs in approximately one third cases and is associated with subsequent cardiovascular events. This study assessed the ability remote ischemic preconditioning (IPC) to attenuate cardiac troponin I (cTnI) release after PCI. Methods Results— Two hundred forty-two consecutive patients undergoing PCI undetectable preprocedural cTnI were recruited. Subjects randomized receive IPC (induced by three...
The very long-term outcome of patients who survive the first few years after receiving cardiac resynchronization therapy (CRT) has not been well described thus far. We aimed to provide outcomes, especially with regard occurrence sudden death (SCD), in CRT without (CRT-P) and defibrillator (CRT-D).A total 1775 patients, ischaemic or non-ischaemic dilated cardiomyopathy, were alive 5 implantation, enrolled this multicentre European observational cohort study. Overall mortality rates specific...
We explored for relationships between SCN5A haploinsufficiency, implicated in clinical arrhythmogenicity, and right ventricular (RV) conduction disorders Langendorff-perfused, male female, young (3 months) old (>12 month old) Scn5a ( +/-) wild type (WT) hearts. The investigated conditions of genotype, age, sex affected latencies but not repolarization time courses RV monophasic action potentials. This prompted examination the patterns epicardial activation, its dispersion, their...
Introduction: Left ventricular (LV) lead placement to the latest contracting area (concordant LV lead) is associated with better response cardiac resynchronization therapy (CRT) compared a discordant lead. However, effect of right (RV) site on CRT unclear. We investigated relationship RV and positions response. Methods: In 131 patients, was positioned preferentially in lateral or posterolateral vein either septum (RVS, n = 55) apex (RVA, 76). The contraction determined two‐dimensional...
Recent studies have reported that human mutations in Nav1.5 predispose to early age onset atrial arrhythmia. The present experiments accordingly assess arrhythmogenicity aging Scn5a+/KPQ mice modeling long QT3 syndrome relationship cardiac Na(+) channel, Nav1.5, expression. Atrial electrophysiological properties isolated Langendorff-perfused hearts from 3- and 12-month-old wild type (WT), were assessed using programmed electrical stimulation their expression by Western blot. Cardiac...
<h3>Objective</h3> Among primary prevention patients with heart failure receiving cardiac resynchronisation therapy (CRT), the impact of additional implantable cardioverter defibrillator (ICD) treatment on outcomes and its interaction sex remains uncertain. We aim to assess whether addition ICD functionality CRT devices offers a more pronounced survival benefit in men compared women, as previous research has suggested. <h3>Methods</h3> Observational multicentre cohort study 5307 consecutive...
Objective In patients indicated for cardiac resynchronisation therapy (CRT), the choice between a CRT-pacemaker (CRT-P) versus defibrillator (CRT-D) remains controversial and indications in this setting have not been well delineated. Apart from inappropriate therapies, which are inherent to presence of defibrillator, whether adding CRT primary prevention impacts risk other acute late device-related complications has studied may bear relevance device selection. Methods Observational...
Abstract Aim: To investigate the interacting effects of age and sex on electrocardiographic (ECG) features Scn5a +/− mice modelling Brugada syndrome. Methods: Recordings were performed anaesthetized wild‐type (WT) differences attributable to these risk factors statistically stratified. Results: exerted sex‐dependent upon sino‐atrial function that only became apparent with age. RR intervals greater in old male than female . Atrio‐ventricular (AV) conduction was slower young mice, whether WT ,...
<b>Objective</b> To quantify the consumption of chocolates in a hospital ward environment. <b>Design</b> Multicentre, prospective, covert observational study. <b>Setting</b> Four wards at three hospitals (where authors worked) within United Kingdom. <b>Participants</b> Boxes Quality Street (Nestlé) and Roses (Cadbury) on anyone eating these chocolates. <b>Intervention</b> Observers covertly placed two 350 g boxes each (eight were used study containing total 258 individual chocolates). These...
Recent studies in rat muscle fibres show that repetitive firing of action potentials causes changes fibre resting membrane conductance (Gm) reflect regulation ClC-1 Cl(-) and KATP K(+) ion channels. Methodologically, these findings were obtained by inserting two microelectrodes at close proximity the same enabling measurements input resistance (Rin) between potential trains. Since length constant (λ) could not be determined, however, calculation Gm relied on assumptions specific cytosolic...
Upgrade to cardiac resynchronization therapy (CRT) should be offered patients who have developed pacing-induced cardiomyopathy with conventional right ventricular pacing. The extent which these would also benefit from defibrillator back-up at the time of CRT upgrade is, however, unknown. Retrospective observational cohort study 199 and no history sustained arrhythmia, including 104 upgraded CRT-Pacemaker (CRT-P) 95 CRT-Defibrillator (CRT-D). incidence arrhythmias risk sudden arrhythmic death...
There remains a debate whether the ventricular volume within prolapsing mitral valve (MV) leaflets should be included in left (LV) end-systolic volume, and therefore factored LV stroke (SV), cardiac magnetic resonance (CMR) assessments. This study aims to compare volumes during phases, with without inclusion of blood on atrial aspect atrioventricular groove but still MV leaflets, against reference SV by four-dimensional flow (4DF). A total 15 patients prolapse (MVP) were retrospectively...
Summary In the present study, we investigated effect of age on atrial electrophysiological properties in Scn5a +/− hearts used to model corresponding increases arrhythmic tendency human B rugada syndrome. Atrial action potential initiation, propagation and recovery were compared young (3 month old) aged (12 old), wild‐type ( WT ) hearts. Multielectrode array recordings assessed spatial intrinsic electrical activity superfused preparations, whereas bipolar electrogram measured basic cycle...
A 51-year-old woman with known primary antiphospholipid syndrome presented a 4-day history of chest and abdominal pain, inferior ST-segment elevation on 12-lead ECG subtherapeutic international normalised ratio. In view significantly raised high-sensitivity troponin I assay, wall hypokinesis transthoracic echocardiography despite unobstructed epicardial vessels emergency coronary angiography, diagnosis myocardial infarction was made. Furthermore, the patient also developed both bilateral...
QT interval prolongation reflecting delayed action potential (AP) repolarization is associated with polymorphic ventricular tachycardia and early after depolarizations potentially initiating extrasystolic APs if of sufficient amplitude. The current experiments explored contributions altered re-excitation thresholds for, conduction of, such to arrhythmogenesis in Langendorff-perfused, normokalaemic, control wild-type hearts two experimental groups modelling long (LQT). LQT consisted...
A 60-year-old man with a cardiac defibrillator implanted due to previous ventricular fibrillation arrest and ischaemic cardiomyopathy received shock while cleaning his fish pond. At the time, immersed arm was close submersed water pump, but patient asymptomatic. As result of he lost consciousness, collapsed backwards, away from Interrogation device revealed high-frequency artefact that sensed by triggered shock. Device parameters were otherwise normal. Subsequently, pump found be source an...
A 59-year-old man, with known metastatic non-small cell lung cancer presented a 3-week history of increasing dyspnoea and clinical features cardiac tamponade. Echocardiography confirmed large …