A5042827208- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- Nutrition, Genetics, and Disease
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Neurological disorders and treatments
- Renal and Vascular Pathologies
- Cardiac tumors and thrombi
- Acute Ischemic Stroke Management
- Advanced X-ray and CT Imaging
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Diabetes Treatment and Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Case Reports on Hematomas
Krajská Nemocnice Liberec
2012-2023
Technical University of Liberec
2015-2023
Centrum kardiovaskulární a transplantační chirurgie
2023
Institute of Clinical and Experimental Medicine
2015-2021
Charles University
2007-2013
Third Way
2008-2009
General University Hospital in Prague
2009
Iscare I.V.F
2007
Objective Macrophage inhibitory cytokine-1 (MIC-1) is a novel regulator of energy homeostasis. We explored whether alterations in MIC-1 levels contribute to metabolic disturbances patients with obesity and/or and type 2 diabetes mellitus (T2DM). Design measured serum its mRNA expression subcutaneous visceral adipose tissue 17 obese nondiabetic women, 14 women T2DM 23 healthy lean women. also the relationship anthropometric biochemical parameters studied influence 2-week very low calorie diet...
Renal artery stenosis (RAS) impacts the pathogenesis and control of heart failure (HF) may further contribute to increased cardiovascular morbidity mortality in HF patients. However, long-term effects renal revascularization on outcomes patients are not well studied.The prevalence its all-cause were studied 163 consecutive with systemic hypertension chronic kidney disease (serum creatinine >2 mg/dL) who underwent percutaneous transluminal angioplasty (PTRA) stenting for atherosclerotic RAS....
Elevated blood glucose levels occur frequently in the critically ill. Tight control by intensive insulin treatment markedly improves clinical outcome.This is a randomized controlled trial comparing laptop-based model predictive algorithm with variable sampling rate [enhanced (eMPC); version 1.04.03] against routine management protocol (RMP) during peri- and postoperative periods.The study was performed at Department of Cardiac Surgery, University Hospital.A total 60 elective cardiac surgery...
Complications of catheter ablation for atrial fibrillation (AF) are frequently related to vascular access. We hypothesized that ultrasound-guided (USG) venipuncture may facilitate the procedure and reduce complication rates.We conducted a multicentre, randomized trial in patients undergoing AF on uninterrupted anticoagulation therapy. The study enrolled consecutive 320 (age: 63 ± 8 years; male: 62%) were USG or conventional 1:1 fashion. It was prematurely terminated due substantially...
Background— Electric left ventricular lead position, assessed by the electric delay from beginning of QRS complex to local LV electrogram (QLV), was found in previous studies be a strong predictor short-term response cardiac resynchronization therapy. We hypothesized that suboptimum position is associated with an excess heart failure events and mortality. Methods Results— analyzed clinical outcome patients bundle branch block or intraventricular conduction treated therapy at our institution...
The very long-term outcome of patients who survive the first few years after receiving cardiac resynchronization therapy (CRT) has not been well described thus far. We aimed to provide outcomes, especially with regard occurrence sudden death (SCD), in CRT without (CRT-P) and defibrillator (CRT-D).A total 1775 patients, ischaemic or non-ischaemic dilated cardiomyopathy, were alive 5 implantation, enrolled this multicentre European observational cohort study. Overall mortality rates specific...
Critical illness induces among other events production of proinflammatory cytokines that in turn interfere with insulin signaling cascade and induce resistance on a postreceptor level. Recently, local renin-angiotensin system adipose tissue has been suggested as possible contributor to the development patients obesity. The aim our study was determine changes subcutaneous epicardial during major cardiac surgery, which may serve model an acute stress potentially affecting endocrine function...
Serum adipocyte fatty acid-binding protein (FABP) concentrations are linked to human obesity and other features of metabolic syndrome. Whether FABP associates with alterations in chronic malnutrition is unknown. In the present study, we measured fasting serum levels FABP, leptin, soluble leptin receptor, adiponectin, resistin, C-reactive (CRP), insulin, glucose, cholesterol triglycerides 19 patients a restrictive type anorexia nervosa (AN) 16 healthy agematched control women (C). Body mass...
Appropriate differentiation capacity of adipose tissue significantly affects its ability to store lipids and protect nonadipose tissues against lipid spillover development insulin resistance. Preadipocyte factor-1 (Pref-1) is an important negative regulator preadipocyte differentiation. The aim our study was explore the changes in circulating Pref-1 concentrations female subjects with obesity (OB) (n=19), females type 2 diabetes mellitus (T2DM) (n=22), sex- age-matched healthy control (C)...
Considerable proportion of patients does not respond to the cardiac resynchronization therapy (CRT). This study investigated clinical relevance left ventricular electrode local electrogram delay from beginning QRS (QLV). We hypothesized that longer QLV indicating more optimal lead placement in late activated regions is associated with higher probability positive CRT response.We conducted a retrospective, single-centre analysis 161 consecutive heart failure and LBBB or nonspecific...
The left ventricular (LV) lead local electrogram (EGM) delay from the beginning of QRS complex (QLV) is considered a strong predictor response to cardiac resynchronization therapy. We have developed method for fast epicardial QLV mapping during video-thoracoscopic surgery guide LV placement.A three-port, approach was used free wall and implantation. A decapolar electrophysiological catheter introduced through one port systematically attached multiple accessible sites. pacing targeted site...
Catheter ablation (CA) for atrial fibrillation (AF) has a considerable risk of procedural complications. Major vascular complications (MVCs) appear to be the most frequent. This study investigated gender differences in MVCs patients undergoing CA AF high-volume tertiary center.A total 4734 CAs (65% paroxysmal, 26% repeated procedures) were performed at our center between January 2006 and August 2018. Patients (71% males) aged 60 ± 10 years had body mass index 29 4 kg/m2 time procedure....
Primary preventive implantation of implantable defibrillator (ICD) is according to current guidelines indicated in patients with heart failure NYHA (New York Heart Association) class II/III and LVEF <35%. Thanks advances pharmacotherapy, a decrease mortality could render benefit ICD insufficient justify its some patients.Study design: multicenter, prospective, randomized, controlled trial evaluating the Cardiac Resynchronization Defibrillator Therapy (CRT-D) or CRT Alone (CRT-P) non-ischemic...
Tako-tsubo kardiomyopatie (nazývaná též stresová či apikální balonový syndrom) je získané onemocnění myokardu charakterizované příznaky napodobujícími akutní koronární syndrom. Patofyziologický mechanismus tohoto není stále zcela pochopen. Obecně akceptovaným mechanismem pravděpodobně katecholaminy indukované omráčení vyvolané stresem, nadměrnou fyzickou námahou nebo vzácně endokrinně aktivními tumory. Uvádíme kazui- stiku pacienta, který byl přijímán na naše pracoviště pro podezření...
Sarkoidóza je multiorgánové granulomatózní zánětlivé onemocnění neznámé etiologie. Srdeční sarkoidóza se klinicky manifestuje zhruba u 5 % nemocných systémovou sarkoidózou, ale pitevní nálezy a moderní zobrazovací metody ukazují na podstatně vyšší výskyt asymptomatického srdeční postižení (20-25 %). Postižení srdce známkou horší prognózy může být život ohrožující. má tři hlavní projevy - atrioventrikulární blokády, komorové arytmie selhání. Diagnostika sarkoidózy náročná, zejména při...
The aim of this study was to investigate the predictors long-term clinical outcome heart failure (HF) patients who survived first year after initiation cardiac resynchronization therapy (CRT).This a single-center observational cohort CRT implanted because symptomatic HF with reduced ejection fraction between 2005 and 2013. Left ventricle (LV) diameters fraction, New York Heart Association (NYHA) class, level N-terminal fragment pro-brain natriuretic peptide (NT-proBNP) were assessed at...