A5010482795- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Pericarditis and Cardiac Tamponade
- Cardiovascular Effects of Exercise
- Atrial Fibrillation Management and Outcomes
- Congenital Heart Disease Studies
- Renal and Vascular Pathologies
- Heart Failure Treatment and Management
- Ultrasound in Clinical Applications
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Health and Disease Prevention
- Infective Endocarditis Diagnosis and Management
- Cardiovascular and exercise physiology
- Cardiac Ischemia and Reperfusion
- Aortic aneurysm repair treatments
- Cardiac Arrhythmias and Treatments
- Cardiovascular Issues in Pregnancy
- Cardiac Arrest and Resuscitation
- Pluripotent Stem Cells Research
Mayo Clinic
2016-2025
Mayo Clinic in Arizona
2016-2025
WinnMed
2014-2025
Mayo Clinic in Florida
2009-2023
Mayo Clinic Health System
2023
Jacksonville College
2023
Mayo Clinic Hospital
2023
Cleveland Clinic
2023
University of Minnesota Rochester
2019
Institute of Clinical and Experimental Medicine
2014-2016
evaluation; surgical procedures; ventricular premature beats; tachycardia; and volatile anesthetics.An independent ERC was commissioned to perform a systematic review of critical question, the results which were incorporated into this CPG.See report published in conjunction with CPG 9 its respective data supplements. 1.2.
Heart failure incidence increases with advancing age, and approximately half of patients heart have preserved left ventricular ejection fraction. Although diastolic dysfunction plays a role in fraction, little is known about age-dependent longitudinal changes function community populations.
Diagnosis of heart failure with preserved ejection fraction (HFpEF) is challenging and relies largely on demonstration elevated cardiac filling pressures (pulmonary capillary wedge pressure). Current guidelines recommend use natriuretic peptides (N-terminal pro-B type peptide) rest/exercise echocardiography (E/e' ratio) to make this determination. Data support practice are conflicting.Simultaneous echocardiographic-catheterization studies were prospectively conducted at rest during exercise...
ABSTRACT Members of the transforming growth factor pβ (TGF‐β) superfamily‐namely, TGF‐β and BMP2—applied to undifferentiated murine embryonic stem cells up‐regulated mRNA mesodermal (Brachyury) cardiac specific transcription factors (Nkx2.5, MEF2C). Embryoid bodies generated from primed with these demonstrated an increased potential for differentiation a significant increase in beating areas enhanced myofibrillogenesis. In environment postmitotic cardiomyocytes, engineered express...
Background— In contrast to the wealth of data on isolated systolic hypertension involving systemic circulation in elderly, much less is known about age-related change pulmonary artery pressure (PASP) and its prognostic impact general population. We sought define relationship between PASP age, evaluate which factors influence PASP, determine whether independently predictive mortality community. Methods Results— A random sample Olmsted County, Minn, population (n=2042) underwent...
Although right ventricular (RV) dysfunction is a major determinant of outcome in patients with pulmonary hypertension (PH), the optimal measure RV function poorly defined. We hypothesized that strain measured by speckle-tracking echocardiography predicts PH over broad range pressures.Prospective peak longitudinal systolic measurement was performed on 575 (mean age, 56 ± 18 years; 63% women) referred for known or suspected PH. Survival status assessed median 16.5 (interquartile range,...
Background Exercise intolerance is common in people with heart failure and preserved ejection fraction (HFpEF). Right ventricular (RV) dysfunction has been shown at rest HFpEF but little data are available regarding dynamic RV-pulmonary artery (PA) coupling during exercise. Methods results Subjects (n = 50) controls 24) prospectively underwent invasive cardiopulmonary exercise testing using high-fidelity micromanometer catheters along simultaneous assessment of RV left (LV) mechanics by...
Abstract Aims Increases in left ventricular filling pressure are a fundamental haemodynamic abnormality heart failure with preserved ejection fraction (HFpEF). However, very little is known regarding how elevated pressures cause pulmonary abnormalities or symptoms of dyspnoea. We sought to determine the relationships between simultaneously measured central haemodynamics, symptoms, and lung ventilatory gas exchange during exercise HFpEF. Methods results Subjects invasively-proven HFpEF (n =...
Detection of heart failure with preserved ejection fraction (HFpEF) involves integration multiple imaging and clinical features which are often discordant or indeterminate.
Abstract Assessment of left ventricular diastolic function plays a major role in the diagnosis and prognosis cardiac diseases, including heart failure with preserved ejection fraction. We aimed to develop an artificial intelligence (AI)-enabled electrocardiogram (ECG) model identify echocardiographically determined dysfunction increased filling pressure. trained, validated, tested AI-enabled ECG 98,736, 21,963, 98,763 patients, respectively, who had echocardiographic assessment within 14...
Reaction to stress requires feedback adaptation of cellular functions secure a response without distress, but the molecular order this process is only partially understood. Here, we report previously unrecognized regulatory element in general syndrome. Kir6.2, ion-conducting subunit metabolically responsive ATP-sensitive potassium (K ATP ) channel, was mandatory for optimal capacity under stress. Genetic deletion Kir6.2 disrupted K channel-dependent adjustment membrane excitability and...
Conventional therapies for myocardial infarction attenuate disease progression without contributing significantly to repair. Because of the capacity de novo cardiogenesis, embryonic stem cells are considered a potential source regeneration, yet limited information is available on their ultimate therapeutic value. We treated infarcted rat hearts with CGR8 preexamined cardiogenicity, serially probed left ventricular function, and determined final pathological outcome. Stem cell delivery...
Invasive hemodynamic exercise testing is commonly used in the evaluation of patients with suspected heart failure preserved ejection fraction (HFpEF) or pulmonary hypertension. Saline loading has been suggested as an alternative provocative maneuver, but changes induced by 2 stresses have not compared.Twenty-six subjects (aged, 67±10 years; n=14 HFpEF; n=12 control) underwent right catheterization at rest, during supine exercise, and acute saline a prospective study. Exercise each increased...
Speckle tracking echocardiography (STE) is a relatively novel and sensitive method for assessing ventricular function may unmask myocardial dysfunction not appreciated with conventional echocardiography. The association of prognosis in sepsis unclear. We sought to evaluate frequency prognostic value biventricular function, assessed by STE patients severe or septic shock.Over an eighteen-month period, sixty were prospectively imaged transthoracic within 24 hours meeting criteria. Myocardial...
Background— Cross-sectional studies suggest that left ventricular (LV) and arterial elastance (stiffness) increase with age, but data examining longitudinal changes within human subjects are lacking. In addition, it remains unknown whether age-related LV stiffening is merely a reaction to or caused by other processes. Methods Results— Comprehensive echo-Doppler cardiography was performed in 1402 participating randomly selected community-based study at 2 examinations separated 4 years. From...