A5085699345- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Digital Radiography and Breast Imaging
- AI in cancer detection
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Breast Cancer Treatment Studies
- Global Cancer Incidence and Screening
- Infective Endocarditis Diagnosis and Management
- BRCA gene mutations in cancer
- Cancer Risks and Factors
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Radiomics and Machine Learning in Medical Imaging
- Cardiomyopathy and Myosin Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Genetic Associations and Epidemiology
- Cardiac pacing and defibrillation studies
- Nutrition, Genetics, and Disease
- Cardiac, Anesthesia and Surgical Outcomes
- Congenital Heart Disease Studies
- Cardiovascular Effects of Exercise
- Parathyroid Disorders and Treatments
- Cardiovascular Disease and Adiposity
Mayo Clinic
2016-2025
Mayo Clinic in Florida
2016-2025
WinnMed
2015-2025
Offshore Installation Services (United Kingdom)
2025
Mayo Clinic in Arizona
2015-2024
Quantitative BioSciences
2023-2024
Texas Tech University Health Sciences Center
2022-2023
Texas Tech University
2023
Mayo Clinic Health System
2023
Society of Thoracic Surgeons
2022
The clinical outcome of asymptomatic mitral regurgitation is poorly defined, and the treatment uncertain. We studied effect on quantifying according to recent guidelines.We prospectively enrolled 456 patients (mean [+/-SD] age, 63+/-14 years; 63 percent men; ejection fraction, 70+/-8 percent) with organic regurgitation, quantified current recommendations (regurgitant volume, 66+/-40 ml per beat; effective regurgitant orifice, 40+/-27 mm2).The estimated five-year rates (+/-SE) death from any...
This study assessed the long-term outcome of a large, asymptomatic population with hemodynamically significant aortic stenosis (AS).We identified 622 patients isolated, AS and peak systolic velocity > or =4 m/s by Doppler echocardiography who did not undergo surgery at initial evaluation obtained follow-up (5.4+/-4.0 years) in all. Mean age (+/-SD) was 72+/-11 years; there were 384 (62%) men. The probability remaining free cardiac symptoms while unoperated 82%, 67%, 33% 1, 2, 5 years,...
Purpose: Androgen deprivation therapy is a common treatment in men with prostate cancer that may cause fatigue, functional decline, increased body fatness, and loss of lean tissue. These physical changes can negatively affect health-related quality life. Resistance exercise help to counter some these side effects by reducing elevating mood, building muscle mass, fat. Methods: In two-site study, 155 who were scheduled receive androgen for at least 3 months after recruitment randomly assigned...
Radiotherapy for prostate cancer (PCa) may cause unfavorable changes in fatigue, quality of life (QOL), and physical fitness. We report results from the Prostate Cancer Exercise Versus Normal Treatment study examining effects 24 weeks resistance or aerobic training versus usual care on QOL, fitness, body composition, prostate-specific antigen, testosterone, hemoglobin, lipid levels men with PCa receiving radiotherapy.Between 2003 2006, we conducted a randomized controlled trial Ottawa,...
Background— Electron-beam computed tomography (EBCT) is used to measure coronary calcification but not for aortic valve (AVC). Its accuracy, association with stenosis (AS) severity, and diagnostic prognostic value respect AVC are unknown. Methods Results— In 30 explanted valves, the score by EBCT (1125±1294 Agatston units [AU]) showed a strong linear correlation ( r =0.96, P <0.0001) valvular calcium weight (653±748 mg) pathology that allowed estimation of as score/1.7, small standard...
Sex and age have long been known to affect the ECG. Several biologic variables anatomic factors may contribute sex age-related differences on We hypothesized that a convolutional neural network (CNN) could be trained through process called deep learning predict person's self-reported using only 12-lead ECG signals. further discrepancies between CNN-predicted chronological serve as physiological measure of health.We CNNs 10-second samples signals from 499 727 patients age. The networks were...
Among patients with severe aortic stenosis (AS) and preserved ejection fraction, those low gradient (LG) reduced stroke volume may have an adverse prognosis. We investigated the prognostic impact of using recently proposed flow-gradient classification.We examined 1704 consecutive AS (aortic valve area <1.0 cm(2)) fraction (≥50%) 2-dimensional Doppler echocardiography. Patients were stratified by index (<35 mL/m(2) [low flow, LF] versus ≥35 [normal NF]) (<40 mm Hg [LG] ≥40 [high gradient,...
Cardiomyocytes are resistant to radiation. However, cardiac radiation exposure causes coronary microvascular endothelial inflammation, a perturbation implicated in the pathogenesis of heart failure (HF) and particularly HF with preserved ejection fraction (HFpEF). Radiotherapy for breast cancer results variable may increase risk HF.We conducted population-based case-control study incident 170 female residents Olmsted County, Minnesota (59 cases 111 controls), who underwent contemporary...
We evaluated whether a 76-locus polygenic risk score (PRS) and Breast Imaging Reporting Data System (BI-RADS) breast density were independent factors within three studies (1643 case patients, 2397 control patients) using logistic regression models. incorporated the PRS odds ratio (OR) into Cancer Surveillance Consortium (BCSC) risk-prediction model while accounting for its attributable compared five-year absolute predictions between models area under curve (AUC) statistics. All statistical...
<h3>Importance</h3> Heart failure (HF) with preserved ejection fraction (HFpEF) is common, frequently associated ventricular wall thickening, and has no effective therapy. Transthyretin amyloid cardiomyopathy (ATTR-CM) can cause the HFpEF clinical phenotype, highly therapy, believed to be underrecognized. <h3>Objective</h3> To examine prevalence of ATTR-CM without systematic screening in patients thickening. <h3>Design, Setting, Participants</h3> This population-based cohort study assessed...
Importance Anthracyclines increase the risk for congestive heart failure (CHF); however, long-term cumulative incidence and factors CHF after anthracycline therapy are not well defined in population-based studies. Objective To compare of patients with breast cancer or lymphoma treated compared healthy controls from same community. Design, Setting, Participants This retrospective case-control study included data Rochester Epidemiology Project. residents Olmsted County, Minnesota, diagnosed...
Detection of heart failure with preserved ejection fraction (HFpEF) involves integration multiple imaging and clinical features which are often discordant or indeterminate.
Background— Left ventricular dysfunction is an indication for aortic valve replacement (AVR) in patients with severe regurgitation (AR). However, the postoperative outcome of AR and a markedly low ejection fraction (EF) not known. Methods Results— The study group consisted total 450 who had AVR isolated between 1980 1995. Patients reduced left function (EF <35%, LoEF, n=43) were compared those moderate reduction 35% to 50%, MedEF, n=134) normal ≥50%, Nl EF, n=273). operative mortality...
Aortic valve calcification (AVC) is considered degenerative. Recent data suggested links to atherosclerosis or coronary disease (CAD).AVC and artery calcifications (CAC) were prospectively assessed by Electron-Beam-Computed-Tomography in 262 population-based research participants > = 60 years. AVC was frequent (27%) with aging (P<0.01) men (P<0.05). associated diabetes, hypertension, higher body-mass-index, serum glucose (all P<0.05). a marker of prevalence severity CAD (CAC score: 441+/-802...
Abstract Mammographic breast density is a strong risk factor for cancer but whether general marker of susceptibility or specific to the location eventual unknown. A study 372 incident cases and 713 matched controls was conducted within Mayo Clinic mammography screening practice. Mammograms on average 7 years before were digitized, quantitative measures percentage dense area from each side view estimated. regional estimate accounting overall calculated both mammogram views. Location potential...