Matthias W. Beckmann
A5044421523- Ovarian cancer diagnosis and treatment
- Breast Cancer Treatment Studies
- Endometrial and Cervical Cancer Treatments
- Endometriosis Research and Treatment
- Cancer Genomics and Diagnostics
- Uterine Myomas and Treatments
- HER2/EGFR in Cancer Research
- Medical and Health Sciences Research
- Cervical Cancer and HPV Research
- Reproductive Biology and Fertility
- Cancer-related molecular mechanisms research
- BRCA gene mutations in cancer
- Advanced Breast Cancer Therapies
- Ovarian function and disorders
- Pregnancy and preeclampsia studies
- Clinical practice guidelines implementation
- Health and Medical Studies
- Cancer Cells and Metastasis
- Cancer Treatment and Pharmacology
- Birth, Development, and Health
- Breast Lesions and Carcinomas
- Estrogen and related hormone effects
- Digital Radiography and Breast Imaging
- AI in cancer detection
- PARP inhibition in cancer therapy
Comprehensive Cancer Center Erlangen
2016-2025
Friedrich-Alexander-Universität Erlangen-Nürnberg
2016-2025
Universitätsklinikum Erlangen
2016-2025
Cancer Research Center
2024
Institute of Medical Ethics
2024
Novartis (Switzerland)
2023
Jazz Pharmaceuticals (United States)
2023
Karyopharm Therapeutics (United States)
2023
Bristol-Myers Squibb (Germany)
2023
AstraZeneca (Canada)
2008-2023
Stratification of women according to their risk breast cancer based on polygenic scores (PRSs) could improve screening and prevention strategies. Our aim was develop PRSs, optimized for prediction estrogen receptor (ER)-specific disease, from the largest available genome-wide association dataset empirically validate PRSs in prospective studies. The development comprised 94,075 case subjects 75,017 control European ancestry 69 studies, divided into training validation sets. Samples were...
Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which turn may promote formation reactive oxygen species, promoting DNA damage expression key regulatory cancer genes. As uncontrolled proliferation are hallmarks cancer, including epithelial ovarian (EOC), we hypothesized that inherited variation genes contributes EOC risk. Methods In total, samples were obtained from 14,525 case subjects...
Circulating tumor cells (CTCs) have been shown to predict reduced survival outcomes in metastatic breast cancer.CTCs were analyzed 2026 patients with early cancer before adjuvant chemotherapy and 1492 after using the CellSearch System. After immuno-magnetic enrichment for expressing epithelial-cell adhesion molecule, CTCs defined as nucleated cytokeratin lacking CD45. The followed a median of 35 months (range = 0-54). Kaplan-Meier analyses log-rank test used analyses. All statistical tests...
Venous thromboembolism is a leading cause of morbidity and mortality during pregnancy the puerperium. However, role mutations in prothrombin factor V genes other thrombophilic abnormalities as risk factors for women puerperium not known.
The Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial (median follow-up, 68 months) has shown that adjuvant anastrozole superior efficacy and better tolerability than tamoxifen. However, reduces circulating estrogen, low estradiol levels are associated with decreased bone mineral density (BMD) increased fracture risk. It is therefore important to understand the effects of long-term aromatase inhibitor therapy on BMD.This prospective substudy ATAC assessed BMD changes postmenopausal...
Cytotoxic CD8+ tumor-infiltrating lymphocytes (TILs) participate in immune control of epithelial ovarian cancer; however, little is known about prognostic patterns TILs by histotype and relation to other clinical factors.
The pathological complete response (pCR) after neoadjuvant chemotherapy is a surrogate marker for favorable prognosis in breast cancer patients. Factors capable of predicting pCR, such as the proliferation Ki67, may therefore help improve our understanding drug and its effect on prognosis. This study investigated predictive prognostic value Ki67 patients with invasive receiving treatment cancer. was stained routinely from core biopsies 552 directly fixation embedding process. HER2/neu,...
What is the success rate in terms of ovarian activity (menstrual cycles) as well pregnancy and delivery rates 1 year after orthotopic transplantations conducted a three-country network? In 49 women with follow-up >1 transplantation, ovaries were active 67% cases 33 25%, respectively. Cryopreservation tissue advance cytotoxic therapies later transplantation being performed increasingly often, total have been described case series. However, published series not allowed either more detailed...
Endometrial cancer is the most commonly diagnosed of female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial cancer. Here, present an expanded meta-analysis 12,906 cases and 108,979 controls (including new genotype data 5624 cases) identify nine novel significant loci, including a locus on 12q24.12 by meta-GWAS colorectal At five expression quantitative trait (eQTL) analyses candidate...
Introduction MicroRNAs (miRNAs, miRs) are a class of small, non-coding RNA molecules with relevance as regulators gene expression thereby affecting crucial processes in cancer development. MiRNAs offer great potential biomarkers for detection due to their remarkable stability blood and characteristic many different diseases. We investigated whether microarray-based miRNA profiling on whole could discriminate between early stage breast patients healthy controls. Methods performed 48 at...
Abstract Identifying molecular alterations in normal tissue adjacent to cancer is important for understanding aetiology and designing preventive measures. Here we analyse the DNA methylome of 569 breast samples, including 50 from cancer-free women 84 matched pairs. We use statistical algorithms dissecting intra- inter-sample cellular heterogeneity demonstrate that characterized by tens thousands epigenetic alterations. show their genomic distribution non-random, being strongly enriched...
BackgroundATP-binding cassette (ABC) transporters play various roles in cancer biology and drug resistance, but their association with outcomes serous epithelial ovarian (EOC) is unknown.
We evaluated whether a 76-locus polygenic risk score (PRS) and Breast Imaging Reporting Data System (BI-RADS) breast density were independent factors within three studies (1643 case patients, 2397 control patients) using logistic regression models. incorporated the PRS odds ratio (OR) into Cancer Surveillance Consortium (BCSC) risk-prediction model while accounting for its attributable compared five-year absolute predictions between models area under curve (AUC) statistics. All statistical...
The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some these are with breast risk as high those rare BRCA2 mutations. We aimed the relative risks specific variants via a multicentre case-control study.
The Mayer-Rokitansky-Kuester-Hauser (MRKH) syndrome is a malformation of the female genitals (occurring in one 4000 live births) as result interrupted embryonic development Müllerian (paramesonephric) ducts. This retrospective study examined issue associated malformations, subtyping, and frequency distribution subtypes MRKH syndrome.Fifty-three patients were investigated using newly developed standardized questionnaire. Together with results clinical diagnostic examinations, classified into...
The eLEcTRA trial compared efficacy and safety of letrozole combined with trastuzumab to alone in patients HER2 hormone receptor (HR) positive metastatic breast cancer (MBC). Patients were randomized either (arm A, n = 31) or plus B, 26) as first-line treatment. Additional 35 negative HR tumors received C).Median time progression arm A was 3.3 months 14.1 B (hazard ratio 0.67; p 0.23) 15.2 C 0.71; 0.03). Clinical benefit rate 39% for 65% (odds 2.99, 95% CI 1.01–8.84) 77% 5.34,...