A5064307236- Bone health and osteoporosis research
- Bone health and treatments
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Vitamin D Research Studies
- Hip and Femur Fractures
- Orthopaedic implants and arthroplasty
- Parathyroid Disorders and Treatments
- Bone fractures and treatments
- Estrogen and related hormone effects
- Medical Imaging and Analysis
- Medical Imaging and Pathology Studies
- Hip disorders and treatments
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Spinal Fractures and Fixation Techniques
- Medical Imaging Techniques and Applications
- Growth Hormone and Insulin-like Growth Factors
- Spine and Intervertebral Disc Pathology
- Adrenal Hormones and Disorders
- Nutrition and Health in Aging
- Birth, Development, and Health
- Scoliosis diagnosis and treatment
- Hormonal and reproductive studies
- Metabolism, Diabetes, and Cancer
University of Sheffield
2016-2025
Sheffield Teaching Hospitals NHS Foundation Trust
2005-2024
Versus Arthritis
2020-2024
Newcastle University
2023-2024
Insigneo
2014-2022
Media Working Group
2022
MRC Lifecourse Epidemiology Unit
2022
University of Southampton
1997-2022
Bone Health and Osteoporosis Foundation
2022
Northern General Hospital
2012-2021
Denosumab is a fully human monoclonal antibody to the receptor activator of nuclear factor-kappaB ligand (RANKL) that blocks its binding RANK, inhibiting development and activity osteoclasts, decreasing bone resorption, increasing density. Given unique actions, denosumab may be useful in treatment osteoporosis.We enrolled 7868 women between ages 60 90 years who had mineral density T score less than -2.5 but not -4.0 at lumbar spine or total hip. Subjects were randomly assigned receive either...
A single infusion of intravenous zoledronic acid decreases bone turnover and improves density at 12 months in postmenopausal women with osteoporosis. We assessed the effects annual infusions on fracture risk during a 3-year period.
Asymptomatic primary hyperparathyroidism (PHPT) is routinely encountered in clinical practices of endocrinology throughout the world. This report distills an update current information about diagnostics, features, and management this disease into a set revised guidelines. Participants, representing international constituency, with interest expertise various facets asymptomatic PHPT constituted four Workshop Panels that developed key questions to be addressed. They then convened open 3-day...
Young adult males who cannot produce or respond to estrogen (E) are osteopenic, suggesting that E may regulate bone turnover in men, as well women. Both bioavailable and testosterone (T) decrease substantially aging but it is unclear which deficiency the more important factor contributing increased resorption impaired formation leads their loss. Thus, we addressed this issue directly by eliminating endogenous T production 59 elderly men (mean age 68 years), studying them first under...
Abstract Zoledronic acid 5 mg (ZOL) annually for 3 years reduces fracture risk in postmenopausal women with osteoporosis. To investigate long-term effects of ZOL on bone mineral density (BMD) and risk, the Health Outcomes Reduced Incidence Once Yearly–Pivotal Fracture Trial (HORIZON-PFT) was extended to 6 years. In this international, multicenter, double-blind, placebo-controlled extension trial, 1233 who received core study were randomized additional (Z6, n = 616) or placebo (Z3P3, 617)....
<h3>Abstract</h3> <b>Objectives:</b> To investigate the effect of milk supplementation on total body bone mineral acquisition in adolescent girls. <b>Design:</b> 18 month, open randomised intervention trial. <b>Subjects:</b> 82 white girls aged 12.2 (SD 0.3) years, recruited from four secondary schools Sheffield. <b>Intervention:</b> 568 ml (one pint) whole or reduced fat per day for months. <b>Main outcome measures:</b> Total content and density measured by dual energy <i>x</i> ray...
The objective is to formulate clinical practice guidelines for the pharmacological management of osteoporosis in postmenopausal women.Evidence from trials and insights experience with pharmacologic therapies were critically evaluated formulating this guideline osteoporosis. Patient preferences, data on adherence persistence, risks benefits patient provider perspectives also considered writing committee deliberations. A consensus by Writing Committee members was achieved four principles: (i)...
Abstract Although it is a cardinal feature of involutional osteoporosis, there often disagreement on what constitutes vertebral fracture. We measured vertebrae T4-L5 in 52 healthy women to develop normal range (mean ± 3 SD) for shape and used these data assess the prevalence fractures. classified fractures by type deformity (wedge, biconcavity, or compression) further degree (grades 1 2). In 195 postmenopausal who were an age-stratified random sample Rochester population (ages 47–94), 40...
Abstract Changes in the level of biochemical markers bone resorption with risedronate treatment for osteoporosis were examined as a surrogate decrease fracture risk. Greater decreases associated greater vertebral (and nonvertebral) fractures. Antifracture efficacy antiresorptive therapies is only partially explained by increases mineral density. Early may also play role. We tested this hypothesis measuring two markers, C-telopeptide type I collagen (CTX) and N-telopeptide (NTX), osteoporotic...
ABSTRACT Denosumab reduces bone resorption and vertebral nonvertebral fracture risk. discontinuation increases turnover markers 3 months after a scheduled dose is omitted, reaching above-baseline levels by 6 months, decreases mineral density (BMD) to baseline 12 months. We analyzed the risk of new or worsening fractures, especially multiple in participants who discontinued denosumab during FREEDOM study its Extension. Participants received ≥2 doses placebo Q6M, treatment, stayed ≥7 last...
The aim was to formulate practice guidelines for management of osteoporosis in men.We used the Grading Recommendations, Assessment, Development, and Evaluation (GRADE) system describe strength recommendations evidence quality.Consensus guided by systematic reviews, one in-person meeting, multiple conference calls e-mails. Task Force drafts were reviewed successively Endocrine Society's Clinical Guidelines Subcommittee Affairs Core Committee; representatives ASBMR, ECTS, ESE, ISCD; members at...
Accurate radiographic diagnosis of vertebral fractures is important. This multicenter, multinational study assessed diagnoses fracture in 2451 postmenopausal women with osteoporosis. Comparison between local and central readings yielded a false-negative rate 34%. Underdiagnosis worldwide problem.Vertebral are the most common complication Although they associated significant morbidity, frequently do not come to clinical attention. important.In prospective (the IMPACT trial), accuracy was...
A number of recent case reports and series have identified a subgroup atypical fractures the femoral shaft associated with bisphosphonate use. population-based study did not support this association. Such relationship has been examined in randomized trials.
Abstract Objective To compare the bone anabolic drug teriparatide (20 μg/day) with antiresorptive alendronate (10 mg/day) for treating glucocorticoid‐induced osteoporosis (OP). Methods This was a 36‐month, randomized, double‐blind, controlled trial in 428 subjects OP (ages 22–89 years) who had received ≥5 mg/day of prednisone equivalent ≥3 months preceding screening. Measures included changes lumbar spine and hip mineral density (BMD), biomarkers, fracture incidence, safety. Results...