A5048250322- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Management of metastatic bone disease
- Genetics, Aging, and Longevity in Model Organisms
- Diabetes Management and Research
- Diabetic Foot Ulcer Assessment and Management
- Pelvic and Acetabular Injuries
- Endoplasmic Reticulum Stress and Disease
- Hip and Femur Fractures
- Bone and Joint Diseases
- Retinoids in leukemia and cellular processes
- Estrogen and related hormone effects
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Musculoskeletal pain and rehabilitation
- Medical Imaging and Analysis
- Diabetes and associated disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Heat shock proteins research
- Biotin and Related Studies
- Vitamin D Research Studies
- Pancreatic function and diabetes
- Diabetes Management and Education
- Intramuscular injections and effects
- Craniofacial Disorders and Treatments
- Adipose Tissue and Metabolism
Diabetes Care Center
2024
Abbott Diabetes Care (United States)
2024
Abbott (United States)
2024
Applied StemCell (United States)
2024
Bigfoot Biomedical (United States)
2023
Medtronic (United States)
2008-2018
Alabama Clincal Therapeutics
2018
University of Alabama at Birmingham
2018
Neurological Surgery
2018
Methodist Sports Medicine
2018
Abstract Vertebral fractures are often painful and lead to reduced quality of life disability. We compared the efficacy safety balloon kyphoplasty nonsurgical therapy over 24 months in patients with acute fractures. Adults one three vertebral were randomized within 3 from onset pain undergo (n = 149) or 151). Quality life, function, disability, assessed months. Kyphoplasty was associated greater improvements Short-Form 36 (SF-36) Physical Component Summary (PCS) scores when averaged across...
<h3>BACKGROUND AND PURPOSE:</h3> Several trials have compared vertebral augmentation with nonsurgical treatment for compression fractures. This trial compares the efficacy and safety of balloon kyphoplasty vertebroplasty. <h3>MATERIALS METHODS:</h3> Patients osteoporosis 1–3 acute fractures (T5–L5) were randomized treated (<i>n</i> = 191) or vertebroplasty 190) not blinded to assignment. Twelve- 24-month subsequent radiographic fracture incidence was primary end point. Due low enrollment...
Multicenter randomized controlled trial.To compare the efficacy and safety of balloon kyphoplasty (BKP) with nonsurgical management (NSM) during 24 months in patients painful vertebral compression fractures (VCFs).Recently, several large trials have been conducted reported how augmentation compares NSM for acute VCFs. Few these report on surgical aspects radiographical deformity results.Adults 1 to 3 VCFs were within pain undergo bilateral BKP (n = 149) or 151). Surgical parameters,...
We characterized the effects of calorie restriction (CR) on expression key glycolytic, gluconeogenic, and nitrogen-metabolizing enzymes in mice. Of gluconeogenic investigated, liver glucose-6-phosphatase mRNA increased 1.7- 2.3-fold young old CR Phospho enolpyruvate carboxykinase activity 2.5- 1.7-fold glycolytic enzymes, pyruvate kinase decreased ∼60% Hepatic phosphofructokinase-1 dehydrogenase 10–20% genes that detoxify ammonia generated from protein catabolism, hepatic glutaminase,...
Osteoporotic and neoplastic vertebral compression fractures (VCF) are common painful, threatening quality of life increasing risk morbidity mortality. Balloon kyphoplasty is a percutaneous option for treating painful cancer- osteoporosis-related VCFs, supported by 2 randomized trials demonstrating efficacy benefits BKP over nonsurgical care.To investigate 12-mo disability, life, safety outcomes specifically in Medicare-eligible population, representing characteristic patients seen routine...
The Bigfoot Unity Diabetes Management System, a smart pen cap system cleared by the U.S. Food and Drug Administration in May 2021, incorporates continuous glucose monitoring data, real-time glycemic alerts, clinician-directed dose recommendations. This study analyzed real-world clinical outcomes data for an initial cohort (n = 58, from 13 clinics) managing multiple daily injection insulin therapy using 6 months. We examined control, including hypoglycemia events interaction with use of...
The steroid-thyroid hormone receptors bind to imperfect repeats of two or more half-sites. It is generally accepted that a T3 response element (TRE) half-site consists six-nucleotide core motif (5'-AGGT(C/A)A-3'). less widely appreciated the nucleotides flanking this also have major influence on affinity receptor (TR) for its element. We analyzed TR-DNA interactions under conditions in which monomers individual TRE half-sites rat GH (rGH) gene was measured. These studies avoided effects...
An osteoclastic protein-tyrosine phosphatase (PTP-oc), essential for osteoclast activity, shows sequence identity with the intracellular domain of GLEPP1, a renal receptor-like transmembrane PTP. PTP-oc has been assumed to be truncated variant resulting from alternative splicing. However, 5'-untranslated region mRNA contains 217 bp an intron GLEPP1. There are no splicing acceptor sites at transcription site. The intronic flanking 5' end start site potential promoter elements transcriptional...
Dietary calorie restriction (CR) delays age-related physiologic changes, increases maximum life span, and reduces cancer incidence. Here, we present the novel finding that chronic reduction of dietary calories by 50% without changing intake protein induced activity mouse hepatic carbamyl phosphate synthetase I (CpsI) 5-fold. In liver, CpsI protein, mRNA, gene transcription were each stimulated ∼3-fold. Thus, CR increased both rate specific enzyme. Short-term feeding studies demonstrated...
<h3>BACKGROUND AND PURPOSE:</h3> Vertebral compression fractures often result in pain and vertebral deformity. We compared 2 different balloon kyphoplasty techniques both using intraoperative curettage. <h3>MATERIALS METHODS:</h3> Adults 50 years of age or older with osteoporosis 1 acute VCF were randomized to undergo bilateral BKP which the curette was used first (<i>n</i> = 57) followed by inflatable bone tamps IBTs first, curettage a second IBT inflation 55). <h3>RESULTS:</h3> Mean...
The vitamin D receptor (VDR) is a transcription factor believed to function as heterodimer with the retinoid X (RXR). However, it was reported [Schräder et al., 1994] that, on putative response elements (VDREs) within rat 9k and mouse 28k calcium binding protein genes (rCaBP mCaBP 28k), VDR thyroid hormone (TR) form heterodimers that transactivate in both 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) triiodothyronine (T(3)). We, therefore, examined associations of these receptors rCaBP VDREs,...
T3 (triiodothyronine) response elements (TREs) consist of pairs strong and weak (S W), 10-nucleotide receptor (TR) monomer binding sites (half-sites). We report that the number order S W half-sites in a direct repeat TRE determines whether it mediates ligand-dependent or independent transcriptional activation inhibition presence TR 9-cis-retinoic acid (RXR); is preferentially bound by homodimers, TR-RXR heterodimers, CV1 cell accessory protein (TRAP)-TR heterodimers. homodimers equally to...
The Bigfoot Unity Diabetes Management System integrates Abbott FreeStyle Libre 2 continuous glucose monitoring (CGM) data into a smart pen cap and mobile app enabling clinician-directed insulin dose recommendations real-time alerts.
The free radical theory of aging predicts that calorie restriction, which extends life span, should reduce oxidant damage. In mammals, the oxidative processes centered in liver are a major source radicals. Liver catalase has dominant role intracellular detoxification hydrogen peroxide. male rodents, published studies indicate decreases gene transcription and restriction obviates this effect. females, inconsistent, no molecular mechanisms have been identified. Here we report that, female...
Background: The Bigfoot Unity® System is an FDA-cleared smart pen cap system incorporating CGM data (Abbott FreeStyle Libre 2), real-time alerts, and clinician-directed insulin dose recommendations. objective was to analyze real world, 3-month for users. Methods: We conducted a per-protocol interim analysis (N=54, 15 clinics) from the prospective, BURST study (NCT05088265). Participants reported baseline demographics completed adverse event surveys every 2 weeks. For A1C data, at-home kit or...