Claus Høgdall
A5019608412- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- BRCA gene mutations in cancer
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Intraperitoneal and Appendiceal Malignancies
- Endometriosis Research and Treatment
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Cancer, Lipids, and Metabolism
- Genetic factors in colorectal cancer
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Molecular Biology Techniques and Applications
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Uterine Myomas and Treatments
- Cancer Risks and Factors
- Bioinformatics and Genomic Networks
- Viral-associated cancers and disorders
- Cell Adhesion Molecules Research
- Renal cell carcinoma treatment
Copenhagen University Hospital
2016-2025
Rigshospitalet
2016-2025
University of Copenhagen
2016-2025
Bristol-Myers Squibb (Germany)
2023
The University of Melbourne
2013-2023
Danish Cancer Society
1995-2023
Novartis (Switzerland)
2023
Jazz Pharmaceuticals (United States)
2023
Karyopharm Therapeutics (United States)
2023
AstraZeneca (Canada)
2023
Background Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which turn may promote formation reactive oxygen species, promoting DNA damage expression key regulatory cancer genes. As uncontrolled proliferation are hallmarks cancer, including epithelial ovarian (EOC), we hypothesized that inherited variation genes contributes EOC risk. Methods In total, samples were obtained from 14,525 case subjects...
Use of 80% oxygen during surgery has been suggested to reduce the risk surgical wound infections, but this effect not consistently identified. The on pulmonary complications well defined.To assess whether use reduces frequency site infection without increasing in patients undergoing abdominal surgery.The PROXI trial, a patient- and observer-blinded randomized clinical trial conducted 14 Danish hospitals between October 2006 2008 among 1400 acute or elective laparotomy.Patients were randomly...
The aim of this study was to estimate the contribution deleterious mutations in RAD51B, RAD51C, and RAD51D genes invasive epithelial ovarian cancer (EOC) population a screening trial individuals at high risk cancer.
BackgroundATP-binding cassette (ABC) transporters play various roles in cancer biology and drug resistance, but their association with outcomes serous epithelial ovarian (EOC) is unknown.
Abstract Breast, ovarian, and prostate cancers are hormone-related may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these totaling 112,349 cases 116,421 controls of European ancestry, all together in pairs, identified at P < 10−8 seven new cross-cancer loci: three associated with susceptibility to (rs17041869/2q13/BCL2L11;...
IntroductionThe clinical role of the molecular endometrial cancer (EC) classification has not been fully explored in patients staged with lymphadenectomy or without adjuvant treatment, conditions that could potentially moderate prognostic value classification. We aimed to evaluate outcome subgroups high-grade EC by and those treatment.MethodsDNA-sequencing for detection pathogenic POLE-exonuclease domain mutations immunohistochemistry mismatch repair (MMR) proteins p53 expression were...
Background:In vitro and observational epidemiological studies suggest that vitamin D may play a role in cancer prevention. However, the relationship between ovarian is uncertain, with generating conflicting findings. A potential limitation of inadequate control confounding. To overcome this problem, we used Mendelian randomization (MR) to evaluate association single nucleotide polymorphisms (SNPs) associated circulating 25-hydroxyvitamin [25(OH)D] concentration risk cancer. Methods: We...
Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized the 3′ untranslated region at putative microRNA (miRNA)-binding sites represent functional targets influence EOC susceptibility. Here, we evaluate association between 767 miRNA-related single-nucleotide polymorphisms (miRSNPs) and risk 18,174 cases 26,134 controls from 43 studies genotyped through...
Observational studies have reported a positive association between body mass index (BMI) and ovarian cancer risk. However, questions remain as to whether this represents causal effect, or holds for all histological subtypes. The lack of observed serous cancers may, instance, be due disease-associated weight loss. Mendelian randomization (MR) uses genetic markers proxies risk factors overcome limitations observational studies. We used MR elucidate the relationship BMI cancer, hypothesizing...
Lymphovascular space invasion (LVSI) occurs in a minority of endometrial cancer (EC) cases, and the extent LVSI is an important risk factor for recurrence and/or metastases. Our aim was to improve reproducibility measuring clinically meaningful by performing quantitative analysis correlation between pelvic lymph node EC. EC samples from PORTEC-1 PORTEC-2 trials were retrieved used collect data, including number LVSI-positive vessels per H&E-stained slide. Using predefined threshold clinical...
Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve stratification. Joint estimation of Single Nucleotide Polymorphism (SNP) effects in models could predictive performance over standard approaches PRS construction. Here, we implemented computationally efficient, penalized, logistic regression (lasso, elastic net, stepwise) individual level genotype data and a Bayesian framework with continuous shrinkage, "select shrink summary statistics" (S4),...
Proteomic investigations of sera are potentially value for diagnosis, prognosis, choice therapy, and disease activity assessment by virtue discovering new biomarkers biomarker patterns. Much debate focuses on the biological relevance need identification such while less effort has been invested in devising standard procedures sample preparation storage relation to model building based complex sets mass spectrometric (MS) data. Thus, development standardized methods collection patient samples...
DNA repair gene polymorphisms and mutations are known to influence cancer risk. We studied whether in double strand break (DSB) genes associated with epithelial ovarian (EOC) Up 1,600 cases 4,241 controls from 4 separate genetic association studies 3 countries were genotyped for 13 single nucleotide (SNP) 6 (BRCA1, NBS1, RAD51, RAD52, XRCC2 XRCC3) involved homologous recombination of breaks. Genotype specific risks estimated as odds ratios (OR) by unconditional logistic regression. No was...
Abstract BACKGROUND The HER‐2 (Human Epidermal Growth factor receptor‐2, also known as c‐ erb ‐2/ neu ) protooncogene encodes a transmembrane receptor protein, M r 185,000. Studies have shown that the oncogene is overexpressed in approximately 25–30% of ovarian carcinoma (OC) cases, but to authors' knowledge, date no consensus regarding overexpression and prognosis has been possible. objective current study was first analyze presence tissue from Danish OC patients correlate distribution with...