Tanja Pejović
A5069625939- Ovarian cancer diagnosis and treatment
- Cancer-related molecular mechanisms research
- Endometrial and Cervical Cancer Treatments
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- BRCA gene mutations in cancer
- RNA Research and Splicing
- Endometriosis Research and Treatment
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Uterine Myomas and Treatments
- Cancer Genomics and Diagnostics
- Genomic variations and chromosomal abnormalities
- PARP inhibition in cancer therapy
- Sarcoma Diagnosis and Treatment
- Reproductive Biology and Fertility
- DNA Repair Mechanisms
- Molecular Biology Techniques and Applications
- Immunotherapy and Immune Responses
- Intraperitoneal and Appendiceal Malignancies
- Bioinformatics and Genomic Networks
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- Immune cells in cancer
Oregon Health & Science University
2015-2024
Providence Medford Medical Center
2024
Health Center
2024
Bristol-Myers Squibb (Germany)
2023
Women's Health Research Institute
2023
Novartis (Switzerland)
2023
Jazz Pharmaceuticals (United States)
2023
Karyopharm Therapeutics (United States)
2023
AstraZeneca (Canada)
2023
Deciphera Pharmaceuticals (United States)
2023
BackgroundATP-binding cassette (ABC) transporters play various roles in cancer biology and drug resistance, but their association with outcomes serous epithelial ovarian (EOC) is unknown.
Structural genetic alterations in cancer often involve gene loss or amplification. With the advent of microarray approaches for analysis genome, as exemplified by array–CGH ( C omparative G enomic H ybridization), scanning gene-dosage is limited only issues DNA density. However, samples interest to pathologist comprise small clusters just a few hundred cells, which do not provide sufficient analysis. We sought develop simple method that would permit amplification whole genome without use...
HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing serous leading us to hypothesize that variation this gene differentially associates with cancer risk according histological subtype. Here comprehensively map respect analyse DNA methylation expression profiles across subtypes. Different single-nucleotide polymorphisms associate invasive (rs7405776 odds ratio (OR)=1.13, P=3.1 × 10−10) (rs11651755 OR=0.77, P=1.6 10−8) cancer. Risk alleles for...
Observational studies have reported a positive association between body mass index (BMI) and ovarian cancer risk. However, questions remain as to whether this represents causal effect, or holds for all histological subtypes. The lack of observed serous cancers may, instance, be due disease-associated weight loss. Mendelian randomization (MR) uses genetic markers proxies risk factors overcome limitations observational studies. We used MR elucidate the relationship BMI cancer, hypothesizing...
Construction of a well-defined mesoporous nanostructure is crucial for applying nonnoble metals in catalysis and biomedicine owing to their highly exposed active sites accessible surfaces. However, it remains great challenge controllably synthesize superparamagnetic CoFe-based nanospheres with tunable compositions large pores, which are sought immobilization or adsorption guest molecules magnetic capture, isolation, preconcentration, purification. Herein, facile assembly strategy block...
Cytogenetic analysis was performed on short-term cultures of primary ovarian carcinomas from 62 patients. successful in 59 cases. Clonal chromosome aberrations were detected 35 tumors. Only numerical changes or a single structural change found five carcinomas: trisomy 12 the sole anomaly two tumors, one tumor had karyotype 50,XX, + 5, 7, 12, 14, fourth balanced t(1;5), and fifth an unbalanced t(8;15). The fact that four these well differentiated suggests simple karyotypic are generally...
DepoVax™ is an innovative and strongly immunogenic vaccine platform. Survivin highly expressed in many tumor types has reported prognostic value. To generate tumor-specific immune response, a novel cancer was formulated DepoVax platform (DPX-Survivac) using survivin HLA class I peptides. Safety potency of DPX-Survivac tested combination with immune-modulator metronomic cyclophosphamide ovarian patients. All the patients receiving therapy produced antigen-specific responses; higher dose...
PTEN loss is a putative driver in histotypes of ovarian cancer (high-grade serous (HGSOC), endometrioid (ENOC), clear cell (CCOC), mucinous (MOC), low-grade (LGSOC)). We aimed to characterise expression as biomarker epithelial large population-based study.
Hypoxia is a key regulator of cancer progression and chemoresistance. Ambiguity remains about how cells adapt to hypoxic microenvironments transfer oncogenic factors surrounding cells. In this study, we determined the effects hypoxia on bioactivity sEVs in panel ovarian (OvCar) cell lines. The data obtained demonstrate varying degree platinum resistance induced OvCar when exposed low oxygen tension (1% oxygen). Using quantitative mass spectrometry (Sequential Window Acquisition All...
Abstract STUDY QUESTION Can group culture with stage-specific anti-Müllerian hormone (AMH) modulation support human follicular development and oocyte maturation in vitro? SUMMARY ANSWER In the presence of FSH, AMH supplementation at secondary-to-early antral stage followed by depletion promotes coordinated growth function follicles during culture, thereby yielding mature oocytes. WHAT IS KNOWN ALREADY Stage-specific in-vitro nonhuman primate follicles. The method supports follicle from...
Background The consequences of defective homologous recombination (HR) are not understood in sporadic ovarian cancer, nor have the potential role HR proteins other than BRCA1 and BRCA2 been clearly defined. However, it is clear that defects DNA repair pathways important to effectiveness current therapies. We hypothesize a subset carcinomas may harbor anomalies pathways, BRCAness profile (defects or pathways) could influence response rate survival after treatment with platinum drugs. Clinical...
ABCB1 encodes the multi-drug efflux pump P-glycoprotein (P-gp) and has been implicated in resistance. We comprehensively evaluated this gene flanking regions for an association with clinical outcome epithelial ovarian cancer (EOC).
Large-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified disease susceptibility variants are located in noncoding regions, and causal genes underlying these associations remain largely unknown. Here, we performed a transcriptome-wide study to search for novel genetic plausible at known GWAS loci. We used RNA sequencing data (68 normal tissue samples from 68 individuals 6,124...