Takayuki Enomoto
A5056238856- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cervical Cancer and HPV Research
- Endometriosis Research and Treatment
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Uterine Myomas and Treatments
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- BRCA gene mutations in cancer
- Monoclonal and Polyclonal Antibodies Research
- PARP inhibition in cancer therapy
- Hepatitis B Virus Studies
- Colorectal and Anal Carcinomas
- Intraperitoneal and Appendiceal Malignancies
- Cancer-related Molecular Pathways
- Genital Health and Disease
- Cancer, Lipids, and Metabolism
- Cancer Risks and Factors
- Virus-based gene therapy research
- Reproductive System and Pregnancy
- Cancer, Hypoxia, and Metabolism
- Sarcoma Diagnosis and Treatment
- Reproductive tract infections research
- Cancer-related molecular mechanisms research
Niigata University
2016-2025
Itami City Hospital
2025
Epson (United States)
2025
Osaka University
2009-2024
Tokyo Institute of Technology
2013-2024
Soka University
2024
Institute of Science Tokyo
2024
Niigata University Medical and Dental Hospital
2013-2023
Japan Clinical Cancer Research Organization
2022
Hokkaido University
2022
Highlights•Endometriosis and uterine endometrium exhibit cancer-associated somatic mutations•Clonal expansion of epithelial cells with mutations in endometriosis•Genomic architecture is heterogeneous•Single endometrial glands carry distinct genesSummaryEndometriosis characterized by ectopic endometrial-like epithelium stroma, which molecular characteristics remain to be fully elucidated. We sequenced 107 ovarian endometriotic 82 normal samples isolated laser microdissection. In both samples,...
High-grade serous ovarian cancers are heterogeneous not only in terms of clinical outcome but also at the molecular level. Our aim was to establish a novel risk classification system based on gene expression signature for predicting overall survival, leading suggesting therapeutic strategies high-risk patients.In this large-scale cross-platform study six microarray data sets consisting 1,054 cancer patients, we developed survival by applying elastic net and 10-fold cross-validation Japanese...
Clear cell carcinoma (CCC) is a rare histologic subtype that demonstrates poor outcomes in epithelial ovarian cancer. The Japanese Gynecologic Oncology Group conducted the first randomized phase III, CCC-specific clinical trial compared irinotecan and cisplatin (CPT-P) with paclitaxel plus carboplatin (TC) patients CCC.Six hundred sixty-seven stage I to IV CCC of ovary were randomly assigned receive 60 mg/m(2) on days 1, 8, 15 day 1 (CPT-P group) every 4 weeks for six cycles or 175 area...
Introduction BRCA gene mutations are associated with hereditary ovarian cancer. plays a key role in genome integrity, and result an increased risk for Although various guidelines recommend testing patients cancer, data on germline (g B RCA ) mutation frequency cancer Japan scarce. Objective This study aimed to determine g BRCA1/2 Japanese stratified by clinicopathological characteristics, assess patients’ satisfaction pre-test genetic counseling. Methods The CHARLOTTE (CHARacterizing the...
Abstract In 2013, recurrent reports of diverse symptoms occurring in girls after receiving HPV vaccination appeared Japanese media. The Ministry Health, Labor and Welfare quickly responded by announcing a temporary suspension its recommendation for the vaccine. rate soon fell to almost zero. present study, we calculated potential future numbers cervical cancer incidence death that will be increased this policy decision. We have assumed number yearly vaccinations is evenly distributed across...
The fundamental morphology of the endometrial glands is not sufficiently understood by 2D observation because these have complicated winding and branching patterns. To construct a large picture gland structure, we performed tissue-clearing-based 3D imaging human uterine tissue. Our immunohistochemistry layer analyses revealed that form plexus network in stratum basalis expand horizontally along muscular layer, similar to rhizome grass. We then extended our method assess tissue affected...
Uterine endometrial cancer is associated with poor survival outcomes in patients advanced-stage disease. Here, we developed a three-dimensional cell cultivation method of endometrioid stem-like cells high aldehyde dehydrogenase (ALDH) activity from clinical specimens. ALDH inhibition synergized paclitaxel to block proliferation. In the setting, ALDH1A1 expression was survival. A level correlated an increase glucose uptake, activation glycolytic pathway, and elevation transporter 1 (GLUT1)....
This phase III, multicenter, randomized, open-label study investigated the efficacy and safety of nivolumab versus chemotherapy (gemcitabine [GEM] or pegylated liposomal doxorubicin [PLD]) in patients with platinum-resistant ovarian cancer.