A5082910812- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Endometriosis Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Cancer Research and Treatments
- Cancer Mechanisms and Therapy
- Uterine Myomas and Treatments
- Ferroptosis and cancer prognosis
- Cancer Cells and Metastasis
- Cervical Cancer and HPV Research
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- PARP inhibition in cancer therapy
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Chromatin Remodeling and Cancer
- Virus-based gene therapy research
- Inflammation biomarkers and pathways
- DNA Repair Mechanisms
- Cancer-related gene regulation
- Reproductive System and Pregnancy
- Monoclonal and Polyclonal Antibodies Research
Kindai University
2015-2025
Kindai University Hospital
2020-2024
Japanese Society of Medical Oncology
2024
Kyoto University
2014-2023
Toyooka Hospital
2022
Shiga Medical Center
2022
Takamatsu Red Cross Hospital
2022
National Sanyo Hospital
2022
Kyoto University Hospital
2012-2019
Fukushima Medical University
2016-2018
Purpose Programmed death-1 (PD-1), a coinhibitory immune signal receptor expressed in T cells, binds to PD-1 ligand and regulates antitumor immunity. Nivolumab is an anti–PD-1 antibody that blocks signaling. We assessed the safety activity of nivolumab patients with platinum-resistant ovarian cancer. Patients Methods Twenty cancer were treated intravenous infusion every 2 weeks at dose 1 or 3 mg/kg (constituting two 10-patient cohorts) from October 21, 2011. This phase II trial defined...
PD-L1 (programmed cell death 1 ligand 1) on tumour cells suppresses host immunity through binding to its receptor PD-1 lymphocytes, and promotes peritoneal dissemination in mouse models of ovarian cancer. However, how expression is regulated cancer microenvironment remains unclear. The number CD8-positive lymphocytes was assessed clinical samples. progression under conditions altering IFN-γ signals assessed. stroma very high peritoneally disseminated tumours, strongly correlated the...
Emerging evidence has highlighted the host immune system in modulating patient response to chemotherapy, but mechanism of this modulation remains unclear. The aim study was analyze effect chemotherapy on antitumor immunity tumor microenvironment ovarian cancer. Treatment cancer cell lines with various chemotherapeutic agents resulted upregulated expression MHC class I and programmed death 1 ligand (PD-L1) a NF-κB-dependent manner suppression antigen-specific T-cell function vitro. In mouse...
The phenotypic transformation of well-differentiated epithelial carcinoma into a mesenchymal-like state provides cancer cells with the ability to disseminate locally and metastasise. Different degrees epithelial–mesenchymal transition (EMT) have been found occur in carcinomas from breast, colon ovarian (OC), among others. Numerous studies focused on bona fide mesenchymal states but rarely intermediate states. In this study, we describe model system for appraising spectrum EMT using 43...
Abstract IFNγ is a cytokine that plays pivotal role in antitumor host immunity. elicits potent immunity by inducing Th1 polarization, CTL activation, and dendritic cell tumoricidal activity. However, there are significant discrepancies our understanding of the as an cytokine. In certain circumstances, obviously acts to induce tumor progression. treatment has negatively affected patient outcomes some clinical trials, while it favorably other trials. Several mechanisms, including insensitivity...
Snail is a major transcriptional factor that induces epithelial-mesenchymal transition (EMT). In this study, we explore the effect of on tumor immunity. knockdown in mouse ovarian cancer cells suppresses growth immunocompetent mice, associated with an increase CD8+ tumor-infiltrating lymphocytes and decrease myeloid-derived suppressor (MDSCs). reduces expression CXCR2 ligands (CXCL1 CXCL2), chemokines attract MDSCs to via CXCR2. upregulates CXCR through NF-kB pathway, most likely, direct...
Abstract Purpose: High VEGF expression in ovarian cancer is an unfavorable prognostic factor. However, the role of tumor immunity remains unclear. Here, we examined impact on local immunity, including induction myeloid-derived suppressor cells (MDSC), cancer. Experimental Design: High-grade serous (HGSOC) cases were analyzed by gene microarray and IHC for VEGF, CD8, CD33. receptor (VEGFR) 1 VEGFR2 levels MDSCs a mouse model, direct effects VEGF-A MDSC expansion investigated. Gr1+ lymphocyte...
Ovarian cancer often progresses by disseminating to the peritoneal cavity, but how tumor cells evade host immunity during this process is poorly understood. Programmed cell death 1 ligand (PD-L1) known suppress immune system and be expressed in cells. The purpose of study elucidate function PD-L1 dissemination.Ovarian cases were studied microarray immunohistochemistry. expression mouse ovarian line various conditions was assessed flow cytometry. PD-L1-overexpression PD-L1-depleted generated,...
Abstract Homologous recombination repair (HRR) pathway deficiency (HRD) is involved in the tumorigenesis and progression of high-grade serous ovarian carcinoma (HGSOC) as well sensitivity to platinum chemotherapy drugs. In this study, we obtained data from The Cancer Genome Atlas (TCGA) on HGSOC identified scores for loss heterozygosity, telomeric allelic imbalance, large-scale state transitions, calculated HRD score. We then investigated relationships among score, genetic/epigenetic...
V-domain Ig suppressor of T cell activation (VISTA) is a novel inhibitory immune-checkpoint protein. VISTA expression on tumour cells and the associated regulatory mechanisms remain unclear. We investigated function in cells, evaluated its mechanism activity. was assessed by tissue microarray analysis, immunohistochemical staining western blot. A series vitro assays were used to determine tumour-expressed VISTA. In vivo efficacy syngeneic models. highly expressed human ovarian endometrial...
Tertiary lymphoid structures (TLS) are transient ectopic aggregates whose formation might be caused by chronic inflammation states, such as cancer. However, how TLS induced in the tumor microenvironment (TME) and they affect patient survival not well understood. We investigated distribution relation to infiltrating lymphocytes (TILs) related gene expression high-grade serous ovarian cancer (HGSC) specimens. CXCL13 correlated with presence infiltration of T cells B cells, it was a favorable...
High-grade serous ovarian cancers are heterogeneous not only in terms of clinical outcome but also at the molecular level. Our aim was to establish a novel risk classification system based on gene expression signature for predicting overall survival, leading suggesting therapeutic strategies high-risk patients.In this large-scale cross-platform study six microarray data sets consisting 1,054 cancer patients, we developed survival by applying elastic net and 10-fold cross-validation Japanese...
Carcinosarcoma (CS) of the uterus or ovary is a rare, aggressive and biphasic neoplasm composed carcinoma sarcoma elements. Previous genomic studies have identified driver genes properties associated with CS. However, there still no molecular subtyping scheme clinical relevance for this disease. Here, we sequence 109 CS samples, focusing on 596 genes. We identify four subtypes that resemble those observed in endometrial carcinoma: POLE-mutated, microsatellite instability, copy number high,...