A5009861049- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Reproductive System and Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Maternal and Perinatal Health Interventions
- Birth, Development, and Health
- Cancer Cells and Metastasis
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Pregnancy-related medical research
- Prenatal Screening and Diagnostics
- Preterm Birth and Chorioamnionitis
- Pregnancy and Medication Impact
- Uterine Myomas and Treatments
- Gestational Trophoblastic Disease Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Endometriosis Research and Treatment
- Cancer Risks and Factors
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Neonatal Respiratory Health Research
- Renal and related cancers
- Congenital Diaphragmatic Hernia Studies
- Cervical Cancer and HPV Research
- Pluripotent Stem Cells Research
Kumamoto University
2021-2025
Nagoya University
2025
Kyoto University
2015-2024
Duke University
2009-2023
Therapeutics Clinical Research
2022
Kyoto University Hospital
2016-2022
Duke Medical Center
2007-2020
Juntendo University
2018
Kyoto Medical Center
2018
Duke University Hospital
2011
The 2017 clinical guidelines for obstetrical practice by the Japan Society of Obstetrics and Gynecology Association Obstetricians Gynecologists were revised published as 2020 edition (in Japanese). aim these is to present appropriate standard obstetric diagnosis management procedures that have reached consensus among Japanese obstetricians. include 113 questions an appendix, followed answers (CQ&A; originally 112 in edition), a discussion, list references, some tables figures presenting...
Recent studies have documented frequent evolution of clones carrying common cancer mutations in apparently normal tissues, which are implicated development1-3. However, our knowledge is still missing with regard to what additional driver events take place order, before one or more these tissues ultimately evolve cancer. Here, using phylogenetic analyses multiple microdissected samples from both and non-cancer lesions, we show unique evolutionary histories breast cancers harbouring der(1;16),...
Sex steroid hormones such as progesterone play a pivotal role in reproductive functions and maintaining pregnancy; however, the impact of on interaction between mother embryo is unclear. Here, we demonstrate that relationship maternal membrane receptor epsilon (mPRε) adipose tissue regulates embryonic nutritional environment growth after birth mice. The activation mPRε by increased during pregnancy enhances insulin resistance via prostaglandin production, efficiently providing glucose to...
Ovarian clear cell carcinoma (OCCC) is a morphologically and biologically distinct subtype of ovarian carcinomas that often arises in endometriosis. We previously reported unique carcinogenic environment, especially iron-induced oxidative stress endometriotic cysts may promote development OCCC. also identified gene expression profile characteristic OCCC (the "OCCC signature"). This 320-gene signature enriched genes associated with response sugar metabolism. However, the biological...
Preeclampsia is one of the leading causes maternal and neonatal mortality morbidity worldwide. We have previously reported that magnesium sulfate therapy effective for early-onset (EO) preeclampsia. To investigate molecular mechanisms underlying this favorable effect, metabolomics analysis sulfate–treated preeclamptic placentas was performed using capillary electrophoresis time flight mass spectrometry. There were significant metabolic differences between EO-preeclamptic (n=7) other...
Serum concentration of oxidized low-density lipoprotein (oxLDL) is higher in women with preeclampsia than normal pregnant woman. Lectin-like oxLDL receptor-1 (LOX-1) one the scavenger receptors for and abundantly expressed placenta. It well known that activates nuclear factor erythroid 2-related 2 (Nrf2), a master regulator antioxidant cytoprotective genes such as heme oxygenase-1 (HO-1), which play an important role preeclampsia. However, it has yet to be elucidated whether LOX-1, along...
The Japan Society of Obstetrics and Gynecology the Association Obstetricians Gynecologists have issued guidelines recommendations on postpartum hemorrhage since 2010 been conducted widespread educational activities from 2012. aim this study was to investigate impact these efforts by Societies prevent maternal deaths due obstetric trends in epidemiology management severe Japan.A national retrospective cohort using database health insurance claims for period 2012 2018. subjects were all...
Obstetric hemorrhage is a leading cause of pregnancy-related mortality. Our hospital protocol states that patients with obstetric undergo initial imaging contrast-enhanced dynamic computed tomography (CE-dCT) to ascertain the presence and location active bleeding, followed by tailored therapeutic interventions. Herein, we aimed elucidate prevailing status clinical outcomes cases at our institution, which are characterized distinctive, methodical treatment approach. This retrospective...
ABSTRACT Objective To evaluate the clinical features of women with vascular retained products conception (RPOC) following delivery and to assess efficacy estrogen–progestogen therapy (EPT) as an initial intervention for this group. Methods A retrospective study was conducted RPOC after at ≥ 20 weeks gestation who received EPT (combination conjugated estrogen norethisterone) between 2017 2023. Clinical characteristics, hormonal levels, ultrasonographic assessments, treatment outcomes were...
Although stress is known to disturb natural fertility through the inhibition of hypothalamic-pituitary-gonadal (HPG) axis, impact on infertile women who receive exogenous gonadal hormones not well defined. This probably due lack experimental models for evaluating impacts an ovarian-independent pathway. The objective this study was investigate possible uterine receptivity, independent HPG axis dysfunction, using a mouse implantation model maintained with hormone supplementation.Blastocysts...
Invasion into deep myometrium and/or lymphovascular space is a well-known risk factor for endometrial cancer metastasis, resulting in poor prognosis. It therefore clinically important to identify novel molecules that suppress tumor invasion. Reduced expression of the metastasis suppressor, kisspeptin (KISS1), and its endogenous receptor, GPR54, has been reported several cancers, but significance KISS1/GPR54 axis not clarified. Metastin-10 minimal bioactive sequence genetic products KISS1....
Placental dysfunction is the underlying cause of common major disorders pregnancy, such as fetal growth restriction and preeclampsia. However, mechanisms placental are not entirely elucidated. We previously reported 10 reliable preeclampsia pathways based on multiple microarray data sets, among which was sonic hedgehog (SHH) pathway. In this study, we describe significant role SHH signaling involved in development growth.The expression levels surrogate markers pathway, patched homolog 1...
Advanced ovarian cancer has a high rate of recurrence and mortality despite relative chemosensitivity at the time initial treatment. Conventional chemotherapeutic agents typically target rapidly dividing cells. Disease relapse may therefore result from survival later emergence latent slow-proliferating and/or quiescent We sought to identify drugs that this cell population investigate influence these cells on outcome patients in remission advanced cancer. Drugs with increased efficacy against...