Nobuyuki Kakiuchi
A5049230435- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Gastrointestinal Tumor Research and Treatment
- Gastrointestinal disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Esophageal Cancer Research and Treatment
- Cancer and Skin Lesions
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Hedgehog Signaling Pathway Studies
- Cancer-related Molecular Pathways
- Neuroendocrine Tumor Research Advances
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Phagocytosis and Immune Regulation
- Oxidative Organic Chemistry Reactions
- Epigenetics and DNA Methylation
- Lymphoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Pancreatic function and diabetes
- Adrenal and Paraganglionic Tumors
- Chemical Synthesis and Reactions
Kyoto University
2016-2025
Institute for Advanced Study
2024
Matsumoto University
2023
Kobe University
2022
Weatherford College
2021
Japanese Foundation For Cancer Research
2019
Kyoto University Hospital
2019
The University of Tokyo
2019
Otsu Red Cross Hospital
2013-2017
Gifu University
2002
Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a diagnosis of exclusion, being the most common entity in mature neoplasms, and its molecular pathogenesis remains significantly understudied. Here, combining whole-exome targeted-capture sequencing, gene-expression profiling, immunohistochemical analysis tumor samples from 133 cases, we have delineated entire landscape somatic alterations, discovered frequently affected driver pathways PTCL, NOS, with without T-follicular...
The extracellular matrix protein laminin 511 is an autoantigen involved in the pathophysiology of autoimmune pancreatitis.
<h3>Objective</h3> IgG4-related disease (IgG4-RD) is a systemic characterised by elevated serum IgG4 and IgG4-positive lymphoplasmacytic infiltration in the affected tissues. The pathogenic role of IgGs, including IgG4, patients with IgG4-RD, however, unknown. <h3>Design</h3> We examined activity circulating IgGs IgG4-RD injecting their into neonatal male Balb/c mice. Binding patient to pancreatic tissue was also analysed an ex vivo mouse organ culture model samples from autoimmune...
Abstract Germ line DDX41 variants have been implicated in late-onset myeloid neoplasms (MNs). Despite an increasing number of publications, many important features DDX41-mutated MNs remain to be elucidated. Here we performed a comprehensive characterization MNs, enrolling total 346 patients with pathogenic/likely-pathogenic (P/LP) germ and/or somatic mutations from 9082 MN patients, together 525 first-degree relatives and wild-type (WT) patients. P/LP explained ∼80% known predisposition...
Recent studies have documented frequent evolution of clones carrying common cancer mutations in apparently normal tissues, which are implicated development1-3. However, our knowledge is still missing with regard to what additional driver events take place order, before one or more these tissues ultimately evolve cancer. Here, using phylogenetic analyses multiple microdissected samples from both and non-cancer lesions, we show unique evolutionary histories breast cancers harbouring der(1;16),...
A heterogenized Pd catalyst, Pd(II)-hydrotalcite (palladium(II) acetate-pyridine complex supported by hydrotalcite) catalyzes the aerobic oxidation in toluene of a variety primary and secondary alcohols into corresponding aldehydes ketones high yields using atmospheric pressure air as sole oxidant under mild conditions. This catalyst is also effective for allylic alcohols, especially such geraniol nerol, without any isomerization an alkenic part. The can be easily prepared from all...
Viral infection induces potent cellular immunity and activated intracellular signaling, which may dictate the driver events involved in immune escape clonal selection of virus-associated cancers, including Epstein-Barr virus (EBV)-positive lymphomas. Here, we thoroughly interrogated PD-L1/PD-L2-involving somatic aberrations 384 samples from various lymphoma subtypes using high-throughput sequencing, particularly focusing on A high frequency genetic was observed EBV-positive lymphomas [33...
Abstract Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare subtype of peripheral affecting younger patients and associated with hemophagocytic lymphohistiocytosis. To clarify the molecular pathogenesis SPTCL, we analyzed paired tumor germline DNAs from 13 by whole-exome sequencing. All cases were Asians phenotypically sporadic no family history SPTCL. Consistent recent report, mutations in HAVCR2, encoding immunoglobulin mucin 3 (TIM3), identified 11 (85%) cases. mutated...
Background and AimsUlcerative colitis is the most frequent type of inflammatory bowel disease characterized by colonic epithelial cell damage. Although involvement autoimmunity has been suggested in ulcerative colitis, specific autoantigens/antibodies have yet to be elucidated.MethodsUsing 23 recombinant integrin proteins, we performed enzyme-linked immunosorbent assays on sera from patients with controls. Integrin expression IgG binding colon tissues controls were examined using...
STAG2 encodes a cohesin component and is frequently mutated in myeloid neoplasms, showing highly significant comutation patterns with other drivers, including RUNX1. However, the molecular basis of cohesin-mutated leukemogenesis remains poorly understood. Here we show critical role an interplay between RUNX1 regulation enhancer-promoter looping transcription hematopoiesis. Combined loss RUNX1, which colocalize at enhancer-rich, CTCF-deficient sites, synergistically attenuates loops,...
Mesenchymal activation, characterized by dense stromal infiltration of immune and mesenchymal cells, fuels the aggressiveness colorectal cancers (CRC), driving progression metastasis. Targetable molecules in tumor microenvironment (TME) need to be identified improve outcome CRC patients with this aggressive phenotype. This study reports a positive link between high thrombospondin-1 (THBS1) expression characteristics, immunosuppression, unfavorable prognosis. Bone marrow-derived monocyte-like...
Abstract With the incorporation of immune checkpoint inhibitors into treatment endometrial cancer (EC), a deeper understanding tumor microenvironment is critical. Tertiary lymphoid structures (TLSs) are considered favorable prognostic factors for EC, but significance their spatial distribution remains unclear. B cell receptor repertoire analysis performed using six TLS samples located at various distances from showed that TLSs in distal areas had more shared clones with tumor-infiltrating...
A catalytic system consisting of vanadium oxyacetylacetonate [VO(acac)2] and 3 Å molecular sieves (MS3A) in acetonitrile works effectively for the aerobic oxidation propargylic alcohols [R1CH(OH)C⋮CR2] to corresponding carbonyl compounds under an atmospheric pressure oxygen. Although reactivity α-acetylenic alkanols (R1 = alkyl) is lower compared that R1 aryl, alkenyl, alkynyl, use VO(hfac)2 as a catalyst addition hexafluoroacetylacetone improve product yield these cases. cycle involving...
Azacitidine is a mainstay of therapy for myelodysplastic syndrome (MDS)-related diseases. The purpose our study to elucidate the effect gene mutations on hematological response and overall survival (OS), particularly focusing their posttreatment clone size. We enrolled total 449 patients with MDS or related myeloid neoplasms. They were analyzed in pretreatment (n = 449) 289) bone marrow samples using targeted-capture sequencing assess impact size treatment outcomes. In Cox proportional...
No specific biomarker for immune checkpoint inhibitor (ICI)-induced colitis has been established. Previously, we identified anti-integrin αvβ6 autoantibodies in >90% of patients with ulcerative (UC). Given that a subset ICI-induced is similar to UC, aimed clarify the relationship between such and colitis.
Palladium(II)-supported hydrotalcite acts as a reusable catalyst for the oxidation of alcohols to aldehydes and ketones in presence pyridine under atmospheric pressure oxygen.
Palladium(II) acetate catalyzes the aerobic oxidation of terminal alkenes in toluene into corresponding methyl ketones presence a catalytic amount pyridine using propan-2-ol as reductant and molecular oxygen an oxidant. Two cycles sharing Pd(II)–OOH species are proposed. One is formation Pd(II)–H to acetone, followed by reaction with give species, other peroxypalladation alkene produced afford ketone H2O2 former cycle.