A5025107885- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Renal and related cancers
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Urological Disorders and Treatments
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Molecular Biology Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Metabolism and Genetic Disorders
- Renal and Vascular Pathologies
- Genetic factors in colorectal cancer
- Ureteral procedures and complications
- Surgical Simulation and Training
- Pancreatic and Hepatic Oncology Research
- Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Pituitary Gland Disorders and Treatments
- Cardiac tumors and thrombi
Iwate Medical University
2019-2025
The University of Tokyo
2013-2021
University of California, San Francisco
2017-2021
San Francisco VA Medical Center
2017-2019
University of Tokyo Hospital
2016-2017
National Center for Global Health and Medicine
2015
Tokyo Metropolitan Komagome Hospital
2009
Cushing’s syndrome is caused by excess cortisol production from the adrenocortical gland. In corticotropin-independent syndrome, primarily attributed to an adenoma, in which underlying molecular pathogenesis has been poorly understood. We report a hotspot mutation (L206R) PRKACA , encodes catalytic subunit of cyclic adenosine monophosphate (cAMP)–dependent protein kinase (PKA), more than 50% cases with adenomas associated syndrome. The L206R mutant abolished its binding regulatory PKA...
Abstract The proteoglycan versican (VCAN) promotes tumor progression and enhances metastasis in several cancers; however, its role clear cell renal carcinoma (ccRCC) remains unknown. Recent evidence suggests that VCAN is an important target of chromosomal 5q gain, one the most prevalent genetic abnormalities ccRCC. Thus, we investigated whether expression associated with pathogenesis was analyzed using three RCC normal kidney lines as well a clinical cohort 84 matched ccRCC tissues....
Objective This study aimed to determine and compare the tumor shrinkage rate its durability by enfortumab vedotin treatment between primary urothelial carcinoma metastatic organs. Methods We retrospectively evaluated in 39 Japanese patients treated with for advanced carcinoma. also periods of maintenance (the period when best response was maintained) regrowth from growth confirmation) Results Measurable organs included lung 17, lymph node 22, liver 6, bone 5 cases. Primary lesion detected 20...
Objectives Nocturnal polyuria (NP) is one of the causes nocturia that impairs quality life. It necessary to consider NP latent when initial treatment for unsatisfactory. Therefore, it important establish a based on pathophysiology. We have previously reported relationship between and fluctuation in blood pressure. The present study aimed investigate association 24‐h pressure fluctuations multicenter prospective study. Methods This included male patients with lower urinary tract symptoms....
Prostate cancer incidence and mortality rates are higher in African-American (AA) than European-American (EA) men. The main objective of this study was to elucidate the role miR-130b as a contributor prostate health disparity AA patients. We also determined whether is prognostic biomarker new therapeutic candidate for cancer. A comprehensive approach using cell lines, tissue samples, TCGA database employed. performed series functional assays such proliferation, migration, invasion, RT2-PCR...
Abstract The prognosis for patients who achieve a pathologic complete response in bladder cancer is excellent, but the association between their and tumor microenvironment unclear. We investigated immune of those with pathological after platinum-based neoadjuvant chemotherapy cT2-4aN0M0 using multiplex fluorescence immunohistochemistry. Our retrospective study included 12 underwent radical cystectomy following muscle-invasive cancer. assessed density several cell types pretreatment...
The aim of this study was to evaluate the clinical validity monitoring urine pellet DNA (upDNA) bladder cancer (BC) by digital PCR (dPCR) as a biomarker for early recurrence prediction, treatment efficacy evaluation, and no-recurrence corroboration. Tumor panel sequencing first performed select patient-unique somatic mutations monitor both upDNA circulating tumor (ctDNA) dPCR. For longitudinal using well plasma ctDNA, an average 7.2 (range, 2 12) time points per case were with dPCR assay 32...
This study aimed to identify novel prognostic biomarker for advanced renal cell carcinoma (RCC) patients treated with anti-PD-1 therapy, using quantitative multi-immunofluorescence (IF) analysis of tumor immunity. Twenty-five consecutive who had metastatic or unresectable RCC therapy were studied. The divided into a responder group (n = 12) and non-responder 13). Quantitative multi-IF staining was performed on biopsy surgical kidney samples panel antibodies. Sections scanned Mantra...
Abstract Biomarkers that could detect the postoperative recurrence of upper tract urothelial carcinoma (UTUC) have not been established. In this prospective study, we aim to evaluate utility individualized circulating tumor DNA (ctDNA) monitoring using digital PCR (dPCR) as a biomarker for UTUC in perioperative period. Twenty‐three patients who underwent radical nephroureterectomy (RNU) were included. each patient, whole exome sequencing by next‐generation and TERT promoter carried out....
Propionimicrobium lymphophilum is an anaerobic Gram-positive bacillus that exists in human skin and urinary tract. The pathogenicity is, however, not well known. Only two cases of tract infection have been described recently. In the case presented here, bacterium was isolated, concomitant with Actinotignum schaalii, from blood culture a patient fever difficulty urination. bacteria were identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry 16S rRNA...
Patients with end-stage renal disease (ESRD) or receiving dialysis have a much higher risk for cell carcinoma (RCC), but carcinogenic mechanisms and genomic features remain little explored undefined. This study's goal was to identify the of ESRD RCC characterize them associations tumor histology exposure. In this study, we obtained 33 RCCs, various histological subtypes, that developed in patients performed whole-genome sequencing transcriptome analyses. Driver events, copy-number alteration...
Introduction Parenchymal renal rupture due to a ureteric calculus is extremely rare and an emergency. Case presentation A 54‐year‐old man was brought the emergency room with left back pain without trauma. Computed tomography showed parenchymal incompletely duplicated pelvis, ureter, 11‐mm in ureterovesical junction. ureteral stent placed, patient treated conservatively as his vital signs were stable. We performed transurethral lithotripsy after resolution of perirenal hematoma. Conclusion To...
Introduction Decreased renal function after radical nephroureterectomy is one of the most important complications because it contributes to decision initiate adjuvant chemotherapy. This study aimed investigate clinical factors associated with changes in elderly patients. Methodology A total 145 patients who underwent for upper tract urothelial carcinoma were evaluated. The was calculated preoperatively, postoperatively, and month long-term change investigated once a year. association between...
Objectives To investigate the association between TMPRSS 2 M et160 V al polymorphism and risk of prostate cancer in J apanese men. Methods Genomic DNA samples from 518 sporadic patients, 433 controls 154 men who were diagnosed as having latent based on autopsy results genotyped for using a T aq an assay. Logistic regression analyses carried out to estimate odds ratios 95% confidence intervals. The relationship presence polymorphism, clinicopathology survival was also examined. Results allele...
Abstract Background A virtual reality (VR) simulator is utilized as an inexpensive tool for gaining basic technical competence in robotic-assisted surgery (RAS). We evaluated operator 3D motion sickness while using a VR and assessed whether it can be reduced by repeating the training. Methods This prospective observational study was conducted at Department of Urology, Iwate Medical University, tertiary training hospital urban setting. total 30 undergraduate medical students participated...